Results 271 to 280 of about 1,163,030 (369)

ENDOMYOCARDIAL FIBROSIS IN TWO BROTHERS [PDF]

, 1963
F. C. Adi
openalex   +1 more source

Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration

Advanced Science, EarlyView.
The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan   +16 more
wiley   +1 more source

Circulating Non-Coding RNAs as Indicators of Fibrosis and Heart Failure Severity. [PDF]

Cells
Boichenko V, Noakes VM, Reilly-O'Donnell B, Luciani GB, Emanueli C, Martelli F, Gorelik J.   +6 more
europepmc   +1 more source

Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization

Advanced Science, EarlyView.
This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan, Donghui Chen, Shuangna Zhang, Chaofan Li, Qingyun Fang, Dinghua Chen, Jiabao Liu, Xin Jiang, Yingjie Zhang, Wanjun Shen, Guangyan Cai, Xiangmei Chen, Ping Li   +12 more
wiley   +1 more source

Normative Modeling Reveals Age-Atypical Cortical Thickness Differences Between Hepatic Steatosis and Fibrosis in Non-Alcoholic Fatty Liver Disease. [PDF]

Brain Behav
Kim M, Hwang I, Choi KS, Lee J, Ryu M, Park JH, Moon JH.   +6 more
europepmc   +1 more source

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

Advanced Science, EarlyView.
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang, Xiangxu Kong, Wei Wang, Huaxin Zhou, Haoran Qu, Zhengyao Guan, Honglei Wu, Xiangyu Zhai, Bin Jin   +8 more
wiley   +1 more source

Tissue-resident Klebsiella quasipneumoniae contributes to progression of idiopathic pulmonary fibrosis by triggering macrophages mitophagy in mice. [PDF]

Cell Death Discov
Xu C, Sun P, Jiang Q, Meng Y, Dong L, Wang X, Hu X, Li C, Li G, Zheng R, You X, Yang X.   +11 more
europepmc   +1 more source

Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90‐HIF‐1α‐Mediated Glycolysis in Kidney Fibrosis

Advanced Science, EarlyView.
When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu, Jinqing Li, Hui Chen, Yingfeng Shi, Xiaoyan Ma, Yi Wang, Xialin Li, Qin Zhong, Yishu Wang, Daofang Jiang, Shougang Zhuang, Na Liu   +11 more
wiley   +1 more source

Increased Vigilance Needed for the Detection of Thrombotic Complications of Central Venous Access in Adolescent Cystic Fibrosis Patients

Frontiers in Pediatrics, 2014
Nandini eKandamany, Basil eElnazir, Peter eGreally   +2 more
doaj   +1 more source

Association of MPO levels with cardiometabolic disease stratified by atherosclerotic cardiovascular risk and intensity of therapy in a workforce population. [PDF]

Sci Rep
Iakoubova OA, Haji-Sheikhi F, Louie JZ, Rowland CM, Arellano AR, Bare LA, Birse CE, Penn MS.   +7 more
europepmc   +1 more source