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Immunobiology of pulmonary fibrosis. [PDF]
Front ImmunolPulmonary fibrosis, an interstitial lung disease, is characterized by progressive thickening and scarring of the lung tissue associated with shortness of breath, decreased vital capacity, and respiratory failure due to the inability to expand and contract the lungs during inspiration with severe morbidity and mortality. The median estimated survival is
Bindu S +5 more
europepmc +3 more sources
Genome-wide DNA methylation dynamics in carbon tetrachloride-induced mice liver fibrosis [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Many persistent harmful stimuli can result in chronic liver diseases, which lead to about 2 million deaths per year in the whole world. Liver fibrosis was found to exist in all kinds of chronic liver diseases.
Deming Li +5 more
doaj +1 more source
Nos2 deficiency enhances carbon tetrachloride-induced liver injury in aged mice [PDF]
Iranian Journal of Basic Medical Sciences, 2020 Objective(s): As a multifunctional molecule, NO has different effects on liver injury. The present work aimed to investigate the effects of Nos2 knockout (KO) on acute liver injury in aged mice treated with carbon tetrachloride (CCl4).
Deming Li +7 more
doaj +1 more source
BMC Medical Education, 2022 Background The purpose of the National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis (CRE-PF) is to improve and extend the lives of patients living with pulmonary fibrosis through the development of a ...
Katherine Christian +7 more
doaj +1 more source
Scientific Reports, 2023 Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease that causes irreversible damage to lung tissue characterized by excessive deposition of extracellular matrix (ECM) and remodeling of lung parenchyma.
Zhongzheng Li +8 more
doaj +1 more source
La Presse Médicale, 2023 Idiopathic pulmonary fibrosis (IPF) is a progressive devastating lung disease with substantial morbidity. It is associated with cough, dyspnea and impaired quality of life. If left untreated, IPF has a median survival of 3 years. IPF affects ∼3 million people worldwide, with increasing incidence in older patients. The current concept of pathogenesis is
Thomas Koudstaal, Marlies S. Wijsenbeek
openaire +2 more sources
Cell Communication and Signaling, 2023 Background Matrix metalloproteinases (MMPs) play important roles in remodeling the extracellular matrix and in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Weiming Zhao +11 more
doaj +1 more source
Pulmonary Fibrosis in Children [PDF]
Journal of Clinical Medicine, 2019 Pulmonary fibrosis (PF) is a very rare condition in children, which may be observed in specific forms of interstitial lung disease. None of the clinical, radiological, or histological descriptions used for PF diagnosis in adult patients, especially in situations of idiopathic PF, can apply to pediatric situations.
Nathan, Nadia +10 more
openaire +3 more sources
Fat storage-inducing transmembrane proteins: beyond mediating lipid droplet formation
Cellular & Molecular Biology Letters, 2022 Fat storage-inducing transmembrane proteins (FITMs) were initially identified in 2007 as members of a conserved endoplasmic reticulum (ER) resident transmembrane protein gene family, and were found to be involved in lipid droplet (LD) formation. Recently,
Gaiping Wang +5 more
doaj +1 more source
Cell Death Discovery, 2023 Idiopathic pulmonary fibrosis is a progressive and fatal interstitial lung disease with a poor prognosis and limited therapeutic options, which is characterized by aberrant myofibroblast activation and pathological remodeling of the extracellular matrix,
Ruyan Wan +10 more
doaj +1 more source