Results 31 to 40 of about 279,445 (313)

MicroRNAs in fibrosis: opportunities and challenges [PDF]

, 2016
MicroRNAs (miRNAs) are small, non-coding RNAs that mediate mRNA cleavage, translational repression or mRNA destabilisation and are around 22-25 nucleotides in length via partial complementary binding to the 3' untranslated region in target transcripts ...
O'Reilly, Steven, Steven O’Reilly
core   +1 more source

Using bacterial biomarkers to identify early indicators of cystic fibrosis pulmonary exacerbation onset

, 2011
Acute periods of pulmonary exacerbation are the single most important cause of morbidity in cystic fibrosis patients, and may be associated with a loss of lung function.
Matt W Johnson, Rogers, Geraint B., Carroll, Mary P., Carroll, Mary P, Mayer-Hamblett, Nicole, Geraint B Rogers, Jürgen Schwarze, Kenneth D Bruce, Mary P Carroll, Johnson, Matt W, Hoffman, Lucas R, Nicole Mayer-Hamblett, Johnson, Matt W., Rogers, Geraint B, Schwarze, Juergen, Schwarze, Jürgen, Bruce, Kenneth D., Lucas R Hoffman, Hoffman, Lucas R., Bruce, Kenneth D   +19 more
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Quality of life is associated with physical activity and fitness in cystic fibrosis [PDF]

, 2014
BACKGROUND: Health-related and disease-specific quality of life (HRQoL) has been increasingly valued as relevant clinical parameter in cystic fibrosis (CF) clinical care and clinical trials.
Helge Hebestreit, Schmid, K, Junge, Sibylle, Hebestreit, Helge Uwe, Hebestreit, H, Schindler, C, Schmid, Kerstin, Kriemler, Susi, Christian Schindler, Schenk, T, Hebestreit, Alexandra, Ballmann, Manfred, Hebestreit, A, Kerstin Schmid, Stephanie Kieser, Hans-Georg Posselt, Manfred Ballmann, Thomas Schenk, Roth, K, Schenk, Thomas, Junge, S, Posselt, H G, Posselt, Hans-Georg, Sibylle Junge, Alexandra Hebestreit, Kieser, Stephanie, Hebestreit, Helge, Ballmann, M, Susi Kriemler, Schindler, Christian, Roth, Kristina, Kristina Roth   +31 more
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Rare and common variants in KIF15 contribute to genetic risk of idiopathic pulmonary fibrosis

, 2022
RATIONALE: Genetic studies of Idiopathic Pulmonary Fibrosis (IPF) have improved our understanding of this disease, but not all causal loci have been identified.
Newton, Chad A, Povysil, Gundula, Martinez, Fernando J, Garcia, Joseph A, Petrovski, Slavé, Li, Qi, Maher, Toby M, Garcia, Christine Kim, Kobeissy, Philippe H, Raghu, Ganesh, Amelotte, Mason, Goldstein, David B, Haefliger, Carolina, Wang, Binhan, Molyneaux, Philip L, Jaouadi, Hager, Noth, Imre, Todd, Jamie L, Palmer, Scott M, Platt, Adam, Zhang, David   +20 more
core   +1 more source

Cough suppression and HRQoL in adult people with cystic fibrosis: an unexplored correlation

Health and Quality of Life Outcomes, 2022
Background Cough suppression assessed by embarrassment about coughing has been shown in adolescents with cystic fibrosis (CF) and negatively affects health-related quality of life (HRQoL) and clinical indicators of disease severity in adolescent females.
Ute Niehammer, Mathis Steindor, Svenja Straßburg, Sivagurunathan Sutharsan, Christian Taube, Matthias Welsner, Raphael Hirtz, Florian Stehling   +7 more
doaj   +1 more source

Modelling forced vital capacity in idiopathic pulmonary fibrosis: optimising trial design. [PDF]

, 2019
INTRODUCTION: Forced vital capacity is the only registrational endpoint in idiopathic pulmonary fibrosis clinical trials. As most new treatments will be administered on top of standard of care, estimating treatment response will become more challenging ...
Meyvisch, Paul, Santermans, Eva, Wijsenbeek, Marlies, Ford, Paul, Wuyts, Wim A, Maher, Toby M, Kreuter, M, Meyvisch, P, Molyneaux, Philip L., Wijsenbeek - Lourens, Marlies, Verbruggen, Nadia, Molyneaux, Philip L, Brown, Kevin K, Lederer, DJ, Maher, Toby M., Brown, KK, Molyneaux, PL, Byrne, AJ, Wuyts, WA, Lederer, David J, Moor, Catharina C, Brown, Kevin K., Moor, Karen, Byrne, Adam J, Lederer, David J., Maher, TM, Byrne, Adam J., Sivananthan, A, Sivananthan, Arunon, Kreuter, Michael, Ford, P, Verbruggen, N, Santermans, E, Moor, Catharina C., Wuyts, Wim A.   +34 more
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Effects of Systemic Enzyme Supplements on Symptoms and Quality of Life in Patients with Pulmonary Fibrosis—A Pilot Study

Medicines, 2021
Current FDA-approved antifibrotic treatments for Idiopathic Pulmonary Fibrosis slow down disease progression but have little impact on symptoms or quality of life in patients.
Neha Shah
doaj   +1 more source

Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. [PDF]

, 2012
Lung function, acute pulmonary exacerbations (APE), and weight are the best clinical predictors of survival in cystic fibrosis (CF); however, underlying mechanisms are incompletely understood.
Rogers, S.L., Sturrock, A., Carveth, Holly, William Walsh, Christen Lane, Walsh, W., James Moore, Li, Yanping, Keogh, R.H., Cox, D.R., Jun Chen (4238), Li, Y., Holly Carveth (143299), Carveth Holly, Judy L. Jensen (143284), William Walsh (143288), Anne Sturrock (143317), Liou Theodore G., Robert Paine III (143322), Ruth H. Keogh (143278), Paine, Robert, Teresa Clark (143295), Hoidal, John R, Cox David R., Adler Frederick R., Moore James, Hoidal John R., Liou, T.G., Shaunessy L. Rogers (143305), Rogers Shaunessy L., David R. Cox (77429), John R. Hoidal (143328), Lane Christen, Lane, C., Ruth H Keogh, Chen, Jun, Packer Kristyn, Kristyn Packer (143291), Frederick R. Adler (143274), Packer, K., Paine Robert, Clark, Teresa, Keogh, Ruth H, Anne Sturrock, Paine, R., Theodore G Liou, David R Cox, Robert Paine, Walsh William, Packer, Kristyn, Hoidal, J.R., Jensen, Judy L, Sturrock, Anne, Yanping Li (90163), Moore, J., Sturrock Anne, Kristyn Packer, Shaunessy L Rogers, Frederick R Adler, Adler, F.R., Clark, T., Rogers, Shaunessy L, Jensen, J.L., Yanping Li, Keogh Ruth H., Chen Jun, Adler, Frederick R, Jun Chen, Liou, Theodore G, Clark Teresa, Theodore G. Liou (143270), Judy L Jensen, John R Hoidal, Li Yanping, Lane, Christen, Christen Lane (143311), Holly Carveth, Chen, J., James Moore (22922), Walsh, William, Teresa Clark, Carveth, H., Jensen Judy L., Cox, David R, Moore, James   +84 more
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Post-COVID-19 Pulmonary Fibrosis: Report of Two Cases [PDF]

, 2021
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 has led to a pandemic situation worldwide. However, remarkable progress has been made in evolving policies, strengthening healthcare efforts, and pharmacotherapy.
Deependra Kumar Rai, Ameet Harishkumar, Priya Sharma, Saurabh Karmakar   +3 more
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source