Results 41 to 50 of about 279,445 (313)

Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis [PDF]

, 2011
Background The balancing functions of pro/anti-inflammatory mediators of the complex innate responses have been investigated in a variety of experimental inflammatory settings. Annexin-A1 (AnxA1) is one mediator of endogenous anti-inflammation, affording
Amílcar S Damazo, Damazo Amílcar S, Damazo, Amilcar S. [UNESP], Perretti, M, Perretti, Mauro, Oliani, Sonia M. [UNESP], Sampaio André LF, Sampaio, Andre L. F., Cintia MAG Nakata, Damazo, AS, Mauro Perretti, Nakata, Cintia M. A. G., Oliani, Sonia M., Roderick J Flower, Sonia M Oliani, Sampaio, ALF, Damazo, Amilcar S., Oliani, SM, Flower, Roderick J., Oliani Sonia M, Flower, RJ, André LF Sampaio, Flower Roderick J, Perretti Mauro, Nakata Cintia MAG, Nakata, CMAG   +25 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Monocyte count as a prognostic biomarker in patients with idiopathic pulmonary fibrosis [PDF]

, 2021
Rationale: There is an urgent need for simple, cost-effective prognostic biomarkers for idiopathic pulmonary fibrosis (IPF); biomarkers that show potential include monocyte count.
Lee, Joyce S, Molyneaux, Philip L, Kreuter, Michael, Tzouvelekis, Argyrios, Maher, Toby M, Atwood, Mark, Kirchgaessler, Klaus-Uwe, Oldham, Justin M, Weycker, Derek   +8 more
core   +1 more source

Validation of gene editing efficiency with CRISPR-Cas9 system directly in rat zygotes using electroporation mediated delivery and embryo culture

MethodsX, 2021
Successful use of the CRISPR-Cas9 system for gene manipulation relies on identifying effective and efficient guide RNA sequences (gRNAs). When the goal is to create transgenic animal/rodent models by knocking-in desired sequences using homology-directed ...
Anil K. Challa, Denise Stanford, Antonio Allen, Lawrence Rasmussen, Ferdinand K. Amanor, S. Vamsee Raju   +5 more
doaj   +1 more source

Idiopathic pulmonary fibrosis [PDF]

Thorax, 2011
Idiopathic pulmonary fibrosis is a progressive lung disease that carries a poor prognosis and for which there are no effective therapies. Although the excessive deposition of extracellular matrix, combined with evidence of recurrent injury to the alveolar epithelium, are well-described there is a pressing need to understand these processes better at a ...
Zhe Hui, Hoo, Moira K B, Whyte
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

How personality influences health outcomes and quality of life in adult patients with cystic fibrosis

BMC Pulmonary Medicine, 2023
Background The present study evaluates personality traits in adult patients with cystic fibrosis (CF) and correlates these results with health-related quality of life (HRQoL) and other clinical parameters indicative of disease severity.
Ute Niehammer, Svenja Straßburg, Sivagurunathan Sutharsan, Christian Taube, Matthias Welsner, Florian Stehling, Raphael Hirtz   +6 more
doaj   +1 more source

Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals RNA N6-methyladenosine modification associated with prognosis and drug resistance in acute myeloid leukemia

Frontiers in Immunology, 2023
IntroductionAcute myeloid leukemia (AML) is a type of blood cancer that is identified by the unrestricted growth of immature myeloid cells within the bone marrow. Despite therapeutic advances, AML prognosis remains highly variable, and there is a lack of
Zhongzheng Li, Xin Liu, Lan Wang, Huabin Zhao, Shenghui Wang, Guoying Yu, Depei Wu, Jianhong Chu, Jingjing Han   +8 more
doaj   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts

Respiratory Research
Background Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function of the lipid and possible mechanisms of increased lipid content in the pathogenesis
Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang, Guoying Yu   +8 more
doaj   +1 more source