Results 61 to 70 of about 789,217 (259)

Immunosuppressive Drug Use in Limited Systemic Sclerosis: An International Survey

Arthritis Care &Research, EarlyView.
Objective Current guidelines recommend immunosuppressive treatment for diffuse cutaneous systemic sclerosis but are less clear on their use in limited cutaneous systemic sclerosis (lcSSc) in the absence of internal organ complications. We conducted an international survey to understand current immunosuppressive drug prescribing patterns in lcSSc ...
Sabrina Hoa, Yicheng Mu, Marie Hudson, Janet Pope   +3 more
wiley   +1 more source

Longitudinal assessment of cystic fibrosis pulmonary diseaseusing clinical, biochemical and emerging microbiological techniques

, 2010
Cystic Fibrosis (CF) causes chronic lower respiratory tract infection leading to morbidity and mortality. CF Pulmonary Exacerbations (CFPEs) cause accentuated symptoms and increase mortality.
Daniels, Thomas William Vaisey
core   +1 more source

Exercise response and the effect of supplemental oxygen during interval training on O2 uptake kinetics, blood lactate levels, and endurance performance in patients with mild, moderate and severe cystic fibrosis [PDF]

, 2011
Background: Exercise performance is reduced in individuals with moderate to severe cystic fibrosis (CF). A ventilatory mechanical limitation, arterial hypoxemia, cardiovascular abnormalities, alteration in O2 uptake kinetics and reduced muscle ...
Reuveny, Ronen
core   +2 more sources

Promoter variants in tissue inhibitor of metalloproteinase-3 (TIMP-3) protect against susceptibility in pigeon breeders' disease. [PDF]

, 2004
BACKGROUND: Tissue inhibitors of metalloproteinases (TIMPs) play a major role in extracellular matrix turnover in the lung. However, in chronic lung disorders such as idiopathic pulmonary fibrosis (IPF) and pigeon breeders' disease (PBD), TIMPs may ...
Briggs, L, Montaño, MM, Pardo, A, Estrada, A, Laurent, GJ, Selman, M, Hill, MR, Pardo-Cemo, Annie   +7 more
core   +1 more source

The Gut–Heart Axis in Systemic Sclerosis: Evidence From a Large Prospective Early Disease Cohort

Arthritis Care &Research, EarlyView.
Objective Cardiac involvement significantly impacts prognosis in systemic sclerosis (SSc), highlighting the need for early risk stratification. Gastrointestinal (GI) symptoms are common and often manifest early. Emerging data suggest a link between GI and cardiac manifestations, possibly through shared mechanisms like dysautonomia.
Francesca R. Di Ciommo, Ashish P. Balar, Aidan K. Strother, Subhash Kulkarni, Michael Hughes, Brian Skaug, Maureen D. Mayes, Shervin Assassi, Ali Y. Ayla, Zsuzsanna H. McMahan   +9 more
wiley   +1 more source

Mutation of hmgA, encoding homogentisate 1,2-dioxygenase, is responsible for pyomelanin production but does not impact the virulence of Burkholderia cenocepacia in a chronic granulomatous disease mouse lung infection

Microbiology Spectrum
The Burkholderia cepacia complex (Bcc) is a group of Gram-negative opportunistic bacteria often associated with fatal pulmonary infections in patients with impaired immunity, particularly those with cystic fibrosis (CF) and chronic granulomatous disease (
Dina A. Moustafa, Linda Wu, Melissa Ivey, Sarah C. Fankhauser, Joanna B. Goldberg   +4 more
doaj   +1 more source

Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis

BMC Medical Research Methodology, 2019
Background Biomarkers of inflammation predictive of cystic fibrosis (CF) disease outcomes would increase the power of clinical trials and contribute to better personalization of clinical assessments.
Theodore G. Liou, Frederick R. Adler, Natalia Argel, Fadi Asfour, Perry S. Brown, Barbara A. Chatfield, Cori L. Daines, Dixie Durham, Jessica A. Francis, Barbara Glover, Theresa Heynekamp, John R. Hoidal, Judy L. Jensen, Ruth Keogh, Carol M. Kopecky, Noah Lechtzin, Yanping Li, Jerimiah Lysinger, Osmara Molina, Craig Nakamura, Kristyn A. Packer, Katie R. Poch, Alexandra L. Quittner, Peggy Radford, Abby J. Redway, Scott D. Sagel, Shawna Sprandel, Jennifer L. Taylor-Cousar, Jane B. Vroom, Ryan Yoshikawa, John P. Clancy, J. Stuart Elborn, Kenneth N. Olivier, David R. Cox   +33 more
doaj   +1 more source

ZNF143 in Chromatin Looping and Gene Regulation

Frontiers in Genetics, 2020
ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence specifically binding to chromatin and activates the expression of protein ...
Bingyu Ye, Bingyu Ye, Bingyu Ye, Bingyu Ye, Bingyu Ye, Bingyu Ye, Ganggang Yang, Ganggang Yang, Ganggang Yang, Ganggang Yang, Ganggang Yang, Ganggang Yang, Yuanmeng Li, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Chunyan Zhang, Qiwen Wang, Qiwen Wang, Qiwen Wang, Qiwen Wang, Qiwen Wang, Qiwen Wang, Guoying Yu, Guoying Yu, Guoying Yu, Guoying Yu, Guoying Yu, Guoying Yu   +30 more
doaj   +1 more source

Distinct Systemic Sclerosis Phenotypes Related to Ethnicity: An Opportunity to Personalize Care?

Arthritis Care &Research, EarlyView.
Objective The objective is to describe and compare demographic, clinical, and serological characteristics of patients with systemic sclerosis (SSc) according to ethnic background. Methods Participants enrolled in the Canadian Scleroderma Research Group cohort who self‐identified to a single ethnicity group were included.
Danick Goulet, Camille Guertin, Maggie Larché, Isabelle Ferdinand, Marie Hudson, May Y. Choi, Mohammed Osman, Janet Pope, Carter Thorne, Murray Baron, Sasha Bernatsky, Sabrina Hoa   +11 more
wiley   +1 more source

Overexpression miR-125a-5p inhibits HSCs activation and alleviates liver fibrosis through TGF-β/Smad2/3 signaling pathway and autophagy

Cell Death Discovery
Liver fibrosis represents an important pathological stage during chronic hepatopathy development, posing a significant threat to human health. Hepatic stellate cells (HSCs), an essential hepatic non-parenchymal cells, have a key effect on fibrogenesis ...
Chunyan Zhang, Yabin Zhao, Haoyu Yan, Jianlin Guo, GuoYing Yu   +4 more
doaj   +1 more source