Results 51 to 60 of about 982,298 (304)

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Modelling forced vital capacity in idiopathic pulmonary fibrosis: optimising trial design. [PDF]

, 2019
INTRODUCTION: Forced vital capacity is the only registrational endpoint in idiopathic pulmonary fibrosis clinical trials. As most new treatments will be administered on top of standard of care, estimating treatment response will become more challenging ...
Meyvisch, Paul, Santermans, Eva, Wijsenbeek, Marlies, Ford, Paul, Wuyts, Wim A, Maher, Toby M, Kreuter, M, Meyvisch, P, Molyneaux, Philip L., Wijsenbeek - Lourens, Marlies, Verbruggen, Nadia, Molyneaux, Philip L, Brown, Kevin K, Lederer, DJ, Maher, Toby M., Brown, KK, Molyneaux, PL, Byrne, AJ, Wuyts, WA, Lederer, David J, Moor, Catharina C, Brown, Kevin K., Moor, Karen, Byrne, Adam J, Lederer, David J., Maher, TM, Byrne, Adam J., Sivananthan, A, Sivananthan, Arunon, Kreuter, Michael, Ford, P, Verbruggen, N, Santermans, E, Moor, Catharina C., Wuyts, Wim A.   +34 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Quality of life is associated with physical activity and fitness in cystic fibrosis [PDF]

, 2014
BACKGROUND: Health-related and disease-specific quality of life (HRQoL) has been increasingly valued as relevant clinical parameter in cystic fibrosis (CF) clinical care and clinical trials.
Helge Hebestreit, Schmid, K, Junge, Sibylle, Hebestreit, Helge Uwe, Hebestreit, H, Schindler, C, Schmid, Kerstin, Kriemler, Susi, Christian Schindler, Schenk, T, Hebestreit, Alexandra, Ballmann, Manfred, Hebestreit, A, Kerstin Schmid, Stephanie Kieser, Hans-Georg Posselt, Manfred Ballmann, Thomas Schenk, Roth, K, Schenk, Thomas, Junge, S, Posselt, H G, Posselt, Hans-Georg, Sibylle Junge, Alexandra Hebestreit, Kieser, Stephanie, Hebestreit, Helge, Ballmann, M, Susi Kriemler, Schindler, Christian, Roth, Kristina, Kristina Roth   +31 more
core   +2 more sources

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Effects of Systemic Enzyme Supplements on Symptoms and Quality of Life in Patients with Pulmonary Fibrosis—A Pilot Study

Medicines, 2021
Current FDA-approved antifibrotic treatments for Idiopathic Pulmonary Fibrosis slow down disease progression but have little impact on symptoms or quality of life in patients.
Neha Shah
doaj   +1 more source

Interstitial pulmonary fibrosis

Chest, 1986
The study of animal models of IPF has demonstrated that there is a stereotyped response of the respiratory airspace walls to a wide variety of injuries. Inflammatory and immune effector cells play a major and complex role in the fibrosing process. They may contribute to the injury of the lung beyond the original insult.
openaire   +2 more sources

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts

Respiratory Research
Background Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function of the lipid and possible mechanisms of increased lipid content in the pathogenesis
Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang, Guoying Yu   +8 more
doaj   +1 more source

Validation of gene editing efficiency with CRISPR-Cas9 system directly in rat zygotes using electroporation mediated delivery and embryo culture

MethodsX, 2021
Successful use of the CRISPR-Cas9 system for gene manipulation relies on identifying effective and efficient guide RNA sequences (gRNAs). When the goal is to create transgenic animal/rodent models by knocking-in desired sequences using homology-directed ...
Anil K. Challa, Denise Stanford, Antonio Allen, Lawrence Rasmussen, Ferdinand K. Amanor, S. Vamsee Raju   +5 more
doaj   +1 more source