Results 51 to 60 of about 789,217 (259)

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

How personality influences health outcomes and quality of life in adult patients with cystic fibrosis

BMC Pulmonary Medicine, 2023
Background The present study evaluates personality traits in adult patients with cystic fibrosis (CF) and correlates these results with health-related quality of life (HRQoL) and other clinical parameters indicative of disease severity.
Ute Niehammer, Svenja Straßburg, Sivagurunathan Sutharsan, Christian Taube, Matthias Welsner, Florian Stehling, Raphael Hirtz   +6 more
doaj   +1 more source

Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals RNA N6-methyladenosine modification associated with prognosis and drug resistance in acute myeloid leukemia

Frontiers in Immunology, 2023
IntroductionAcute myeloid leukemia (AML) is a type of blood cancer that is identified by the unrestricted growth of immature myeloid cells within the bone marrow. Despite therapeutic advances, AML prognosis remains highly variable, and there is a lack of
Zhongzheng Li, Xin Liu, Lan Wang, Huabin Zhao, Shenghui Wang, Guoying Yu, Depei Wu, Jianhong Chu, Jingjing Han   +8 more
doaj   +1 more source

Role of pirfenidone in the management of pulmonary fibrosis [PDF]

, 2017
Keith C Meyer,1,2 Catherine A Decker3,4 1University of Wisconsin Lung Transplant and Advanced Lung Disease Program, 2Department of Medicine, Section of Allergy, Pulmonary and Critical Care Medicine, Clinical Sciences Center, University of Wisconsin ...
Catherine Decker, Keith Meyer, Meyer KC, Decker CA   +3 more
core   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Signaling pathways of liver regeneration: Biological mechanisms and implications

iScience
Summary: The liver possesses a unique regenerative ability to restore its original mass, in this regard, partial hepatectomy (PHx) and partial liver transplantation (PLTx) can be executed smoothly and safely, which has important implications for the ...
Chunyan Zhang, Caifang Sun, Yabin Zhao, Bingyu Ye, GuoYing Yu   +4 more
doaj   +1 more source

Blood transcriptomic predicts progression of pulmonary fibrosis and associates natural killer cells. [PDF]

, 2021
Rationale: Disease activity in idiopathic pulmonary fibrosis (IPF) remains highly variable, poorly understood, and difficult to predict. Objective: To identify a predictor using short-term longitudinal changes in gene-expression that forecasts future ...
Barros, Andrew J., Ma, Shwu-Fan, Maher, Toby M, Huang, Yong, Martinez, Fernando J., Herazo-Maya, Jose D., Molyneaux, Philip L., Oldham, Justin M, Bonham, Catherine A., Kim, John S, Molyneaux, Philip L, Moore, Bethany B., Maher, Toby M., Noth, Imre, Strek, Mary E, Oldham, Justin M., Adegunsoye, Ayodeji, Herazo-Maya, Jose D, Martinez, Fernando J, Kim, John S., Bonham, Catherine A, Moore, Bethany B, Unterman, Avraham, Liao, Shu-Yi, Barros, Andrew J, Kaminski, Naftali, Vij, Rekha, Strek, Mary E., Bethany B. Moore, Avraham Unterman, Yong Huang, Toby M. Maher, Ayodeji Adegunsoye, Philip L. Molyneaux, Jose D. Herazo-Maya, Shwu-Fan Ma, Rekha Vij, John S. Kim, Mary E. Strek, Naftali Kaminski, Fernando J. Martinez, Catherine A. Bonham, Imre Noth, Shu-Yi Liao, Justin M. Oldham, Andrew J. Barros   +45 more
core   +1 more source

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence

Respiratory Research
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal, and aging-associated interstitial lung disease with a poor prognosis and limited treatment options, while the pathogenesis remains elusive.
Ruyan Wan, Siqi Long, Shuaichen Ma, Peishuo Yan, Zhongzheng Li, Kai Xu, Hui Lian, Wenwen Li, Yudi Duan, Miaomiao Zhu, Lan Wang, Guoying Yu   +11 more
doaj   +1 more source

A case of left atrial myxoma accompanied by pancytopenia and pathological findings suggestive of pulmonary hypertension [PDF]

, 1974
A case of left atrial myxoma accompanied by peculiar symptoms is reported. A 15-year old boy had progressive congestive heart failure and three episodes of acute attacks of panctyopenia. The anemia was accompanied by helmet-shaped, broken red blood cells,
Ogawa, Katsuo, Ofuji, Tadashi, Sato, Keiichiro, Kawanishi, Koichi   +3 more
core   +1 more source