Results 71 to 80 of about 789,217 (259)

ROCKing pulmonary fibrosis [PDF]

Journal of Clinical Investigation, 2013
Clinical vignette: A 76-year-old man consults you for increasing shortness of breath over the past two years and an increasing requirement for home oxygen. A video-assisted thoracoscopic lung biopsy shows findings of usual interstitial pneumonitis, and he has no identifiable cause for pulmonary fibrosis, so he is considered to have idiopathic pulmonary
openaire   +4 more sources

Bacterial burden in the lower airways predicts disease progression in idiopathic pulmonary fibrosis and is independent of radiological disease extent [PDF]

, 2019
Increasing bacterial burden in the lower airways of patients with idiopathic pulmonary fibrosis confers an increased risk of disease progression and mortality.
Renzoni, E, Molyneaux, Philip, Wu, Zhe, Ghai, Poonam, Devaraj, A, Byrne, ada, Barnett, joe, Wells, Athol, Rawal, Bhavin, Maher, toby, Invernizzi, Rachele, Nair, Arjun, Kingston, shaun, Lloyd, Clare, Chua, Felix, Rice, Alexandra, Nicholson, Andrew   +16 more
core   +1 more source

Real‐World Safety and Effectiveness of JAK Inhibitors in Systemic Sclerosis: A Propensity‐Matched Study From the EUSTAR Cohort

Arthritis Care &Research, EarlyView.
Objective JAK inhibitors (JAKi) have shown promising effects in early‐phase studies of systemic sclerosis (SSc). We aimed to assess the safety and explore the effectiveness of JAKi compared to conventional immunosuppressants in SSc. Methods A longitudinal retrospective study of the European Scleroderma Trials and Research Group (EUSTAR) cohort was ...
Stefano Di Donato, Marie‐Elise Truchetet, Marco Minerba, Oliver Distler, Juan José Alegre Sancho, Yolanda Braun‐Moscovici, Christina Bergmann, Petros Sfikakis, Jeska K. de Vries‐Bouwstra, Murray Baron, Silvia Bellando‐Randone, Lorenzo Dagna, Christopher P. Denton, Madelon C. Vonk, Vanessa Smith, Ivan Castellvi, Gabriela Riemekasten, Andra Balanescu, Masataka Kuwana, Maria De Santis, Kamal Solanki, Anastas Batalov, Vahan Mukuchyan, Marco Matucci‐Cerinic, Yannick Allanore, Francesco Del Galdo, Michael Hughes, EUSTAR Collaborators   +27 more
wiley   +1 more source

Determinants of Body Mass Index in Early Systemic Sclerosis: Implications for Nutritional Risk Stratification

Arthritis Care &Research, EarlyView.
Objective Gastrointestinal (GI) involvement can lead to malnutrition in patients with systemic sclerosis (SSc). Body mass index (BMI) remains the most widely used marker to screen nutritional status. We aimed to identify predictors of lower BMI in patients with SSc. Methods Patients with SSc from a prospective US cohort meeting 2013 American College of
Ali Y. Ayla, Meng Zhang, Bingrui Chen, Claudia Pedroza, Brian Skaug, Maureen Mayes, Michael Hughes, Shervin Assassi, Zsuzsanna H. McMahan   +8 more
wiley   +1 more source

Endogenous annexin A1 counter-regulates bleomycin-induced lung fibrosis [PDF]

, 2011
Background The balancing functions of pro/anti-inflammatory mediators of the complex innate responses have been investigated in a variety of experimental inflammatory settings. Annexin-A1 (AnxA1) is one mediator of endogenous anti-inflammation, affording
Amílcar S Damazo, Damazo Amílcar S, Damazo, Amilcar S. [UNESP], Perretti, M, Perretti, Mauro, Oliani, Sonia M. [UNESP], Sampaio André LF, Sampaio, Andre L. F., Cintia MAG Nakata, Damazo, AS, Mauro Perretti, Nakata, Cintia M. A. G., Oliani, Sonia M., Roderick J Flower, Sonia M Oliani, Sampaio, ALF, Damazo, Amilcar S., Oliani, SM, Flower, Roderick J., Oliani Sonia M, Flower, RJ, André LF Sampaio, Flower Roderick J, Perretti Mauro, Nakata Cintia MAG, Nakata, CMAG   +25 more
core   +1 more source

Engagement Patterns With an Artificial Intelligence Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

Arthritis Care &Research, EarlyView.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah, Melanie Morris, Cristina Daraban, Sophia Johnson, Susan L. Murphy   +4 more
wiley   +1 more source

Clinician and Patient Factors Associated With Long‐Term Glucocorticoid Use in People With Rheumatoid Arthritis Receiving Advanced Therapies

Arthritis Care &Research, EarlyView.
Objective Despite guideline recommendations, long‐term glucocorticoid (GC) use is common in rheumatoid arthritis (RA). We conducted a clinician survey nested within a large registry to identify patient and clinician factors associated with GC use. Methods Clinicians contributing patients to the CorEvitas Rheumatoid Arthritis Registry were surveyed ...
Michael D. George, George Reed, Matthew D. Kearney, Peter F. Cronholm, Kevin Kane, Jeffrey R. Curtis, Dimitrios A. Pappas, Joel M. Kremer   +7 more
wiley   +1 more source

Infant Pulmonary Function Testing in Pediatric Diffuse Parenchymal Lung Disease

CHEST Pulmonary
Topic Importance: Diffuse parenchymal lung disease (DPLD) in pediatrics, also known as children’s interstitial lung disease, comprises a diverse group of rare and chronic respiratory disorders affecting the pediatric population. Diagnosing and monitoring
Avigdor Hevroni, MD, Alex Gileles-Hillel, MD, Malena Cohen-Cymberknoh, MD, Joel Reiter, MD, David Shoseyov, MD, Reuven Tsabari, MD, Chaim Springer, MD, Laurice S. Boursheh, MD, Oded Breuer, MD   +8 more
doaj   +1 more source

Aging and Pulmonary Fibrosis

Revista de Investigación Clínica, 2016
Idiopathic pulmonary fibrosis is a chronic, progressive, and usually fatal lung disorder of unknown etiology. The disease likely results from the interaction of genetic susceptibility architecture, environmental factors such as smoking, and an abnormal epigenetic reprogramming that leads to a complex pathogenesis.
Moisés, Selman, Ivette, Buendía-Roldán, Annie, Pardo   +2 more
openaire   +2 more sources

Beyond Visual Scoring: Computational Computed Tomography Analysis for High‐Resolution Computed Tomography–Based Quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Arthritis Care &Research, EarlyView.
Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRDs). High‐resolution computed tomography (HRCT) is widely considered the gold standard for the noninvasive assessment of ILD; however, its interpretation is constrained by substantial interobserver variability and the ...
Alexander Pfeil, Tobias Hoffmann, Ulf Teichgräber, Diane Renz, Denise Beckmann, Gunter Wolf, Nicole Schadewaldt, Bianca Lassen‐Schmidt   +7 more
wiley   +1 more source