Results 91 to 100 of about 280,725 (312)

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

A randomised clinical trial of a digital self-management package for people with interstitial lung disease: the REBUILD-SM protocol

Respiratory Research
Background Interstitial lung disease (ILD) has a profound impact upon health-related quality of life (HRQoL) and mortality. Patients with ILD have identified their desire for tools to improve self-management. This study compares the clinical efficacy and
Carly Barton, Mariana Hoffman, Narelle S. Cox, Laura M. Glenn, Joanna Y. T. Lee, Ingrid Cox, Nicole S. L. Goh, Lauren K. Troy, John Mackintosh, Daniel C. Chambers, Ian N. Glaspole, Val Gebski, Anthony Keech, Andrew Palmer, Liliana Laranjo, Luke D. Knibbs, Yuben Moodley, Mark Brooke, Anne E. Holland, Tamera J. Corte   +19 more
doaj   +1 more source

A Systematic Study of GelMA‐Carbopol Bioinks for High‐Fidelity Extrusion 3D Bioprinting at Physiological Temperatures

Advanced Healthcare Materials, EarlyView.
Gonzalez Martinez and collaborators develop a strategy to formulate high performance GelMA‐based bioinks with low solids contents. The resulting bioinks enable 3D bioprinting at 37 °C of high‐fidelity structures with tunable mechanical properties that support high cell viability and function.
David A. González‐Martínez, Aidee V. Arizpe Tafoya, Eduardo González‐Martínez, Mabel Barreiro Carpio, Laura Daniela Serrano Andrade, Christopher T. N. Chow, Mohammadhossein Dabaghi, Jeremy A. Hirota, Jose M. Moran‐Mirabal   +8 more
wiley   +1 more source

Role of pirfenidone in the management of pulmonary fibrosis [PDF]

, 2017
Keith C Meyer,1,2 Catherine A Decker3,4 1University of Wisconsin Lung Transplant and Advanced Lung Disease Program, 2Department of Medicine, Section of Allergy, Pulmonary and Critical Care Medicine, Clinical Sciences Center, University of Wisconsin ...
Catherine Decker, Keith Meyer, Meyer KC, Decker CA   +3 more
core   +2 more sources

SYISL promotes pulmonary epithelial-mesenchymal transition and fibrosis through DSP–Hippo/YAP pathway

Cellular and Molecular Life Sciences
Long non-coding RNAs (lncRNAs) are pivotal regulators of cellular processes, but their specific functions in pulmonary epithelial homeostasis and idiopathic pulmonary fibrosis (IPF) pathogenesis are not fully defined.
Cong Xia, Sining Hou, Xuqian Wang, Wenyu Zhao, Zhixia Wang, Airu Chang, Lianhui Cheng, Huibing Liu, Jiawei Wang, Bin Li, Xin Pan, Shuang Huang, Ying Cao, Sakamoto Koji, Zhongzheng Li, Qiwen Wang, Andrew Leask, Lan Wang, Guoying Yu   +18 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

A pilot study of the impact of high-frequency chest wall oscillation in chronic obstructive pulmonary disease patients with mucus hypersecretion [PDF]

, 2011
Indranil Chakravorty1, Kamaljit Chahal2, Gillian Austin21St George's Hospital, London, 2East and North Hertfordshire NHS Trust, Lister Hospital and Primary Care Trust, Stevenage, Hertfordshire, UKIntroduction: Chronic obstructive pulmonary ...
Chahal, K, Chakravorty, I, Chahal K, null Chahal, Austin G, Chakravorty I, Indranil Chakravorty, Austin, G, null Austin   +8 more
core   +1 more source

C/EBPγ interacts with C/EBPα and activates the β-catenin pathway in idiopathic pulmonary fibrosis

Cellular and Molecular Life Sciences
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease characterized by an abnormal epithelial‒mesenchymal transition (EMT) and fibroblast activation, although the molecular mechanisms driving these processes remain ...
Xiaoyue Pan, Cong Xia, Yulong Gan, Ying Cao, Man Zhao, Huibing Liu, Yanlin Zhou, Yuqi Wang, Zhongzheng Li, Bin Li, Lan Wang, Guoying Yu   +11 more
doaj   +1 more source

ROCKing pulmonary fibrosis [PDF]

Journal of Clinical Investigation, 2013
Clinical vignette: A 76-year-old man consults you for increasing shortness of breath over the past two years and an increasing requirement for home oxygen. A video-assisted thoracoscopic lung biopsy shows findings of usual interstitial pneumonitis, and he has no identifiable cause for pulmonary fibrosis, so he is considered to have idiopathic pulmonary
openaire   +4 more sources