Results 91 to 100 of about 789,217 (259)

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Epidemiology of idiopathic pulmonary fibrosis

, 2013
Brett Ley, Harold R Collard Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco, San Francisco, California, USA Abstract: Idiopathic pulmonary fibrosis is a chronic fibrotic lung disease of ...
Ley B, Collard HR
core  

High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells. [PDF]

, 2011
Transforming growth factor beta 1 (TGFβ1) plays a major role in many lung diseases including lung cancer, pulmonary hypertension, and pulmonary fibrosis.
Friedman, N, Oliver Eickelberg, Yu, H, Richards, T., Kaplan, Tommy, Yingze Zhang, Kaplan, T, Pandit, Kusum V., Zhang, Y., Kusum V. Pandit, Richards, Thomas, Benos, Panayiotis V., Zeng, Q, Bais, A.S., Pandit, K.V., Kaminski, N., Handley, D, Bais, Abha S, Richards, T, Panayiotis V. Benos, Handley, Daniel, Richards Thomas, Haiying Yu, Bais, AS, Eickelberg, O, Benos, PV, Nir Friedman, Handley, D., Tommy Kaplan, Friedman, N., Pandit, Kusum V, Zeng, Q., Zhang, Yingze, Abha S Bais, Eickelberg, O., Kusum V Pandit, Bais Abha S., Zeng, Qilu, Yu, Haiying, Panayiotis V Benos, Kaplan, T., Eickelberg Oliver, Kaminski, N, Benos, Panayiotis V, Benos, P.V., Thomas Richards, Eickelberg, Oliver, Naftali Kaminski, Zeng Qilu, Daniel Handley, Pandit, KV, Bais, Abha S., Zhang, Y, Yu Haiying, Kaminski, Naftali, Yu, H., Qilu Zeng, Kaminski Naftali, Benos Panayiotis V., Handley Daniel, Friedman, Nir, Pandit Kusum V., Zhang Yingze, Kaplan Tommy, Friedman Nir, Abha S. Bais   +65 more
core   +1 more source

Microfluidic Nano‐Assembly of Red‐Blood‐Cell (RBC) Lipids and Components for Engineering Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
Engineered red blood cell‐derived extracellular vesicles (eRBCEVs) are synthesized via controlled microfluidic assembly from native RBC lipids, enabling tunable encapsulation of proteins, nucleic acids, nanoparticles, and viral vectors. The platform demonstrates reproducible nanoscale architecture, preserved membrane composition, and functional cargo ...
Chiranth K. Nagaraj, Xilal Y. Rima, Kim T. Nguyen, Courtney Culkins, Nana Boateng, Jacob Doon‐Ralls, Alejandro Bresolin, Xin Huang, Hong Li, Vahedi Amid, Ajeet Pal Singh, Dharti Shantaram, Anastasiia Amari, Mangesh D. Hade, Nicholas R. Merriam, Zachary D. Schultz, Scott Q. Harper, Nizar Y. Saad, Setty M. Magaña, Willa A. Hsueh, Rachel E. Kopec, Blaise R. Kimmel, Andre F. Palmer, Eduardo Reátegui   +23 more
wiley   +1 more source

C/EBPγ interacts with C/EBPα and activates the β-catenin pathway in idiopathic pulmonary fibrosis

Cellular and Molecular Life Sciences
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease characterized by an abnormal epithelial‒mesenchymal transition (EMT) and fibroblast activation, although the molecular mechanisms driving these processes remain ...
Xiaoyue Pan, Cong Xia, Yulong Gan, Ying Cao, Man Zhao, Huibing Liu, Yanlin Zhou, Yuqi Wang, Zhongzheng Li, Bin Li, Lan Wang, Guoying Yu   +11 more
doaj   +1 more source

Topically Delivered Treg‐Attracting Microparticle‐Hydrogel Composites Recruit Regulatory T Cells and Limit Cardiac Injury After Severe Ischemia

Advanced Healthcare Materials, EarlyView.
CCL22‐releasing PLGA microparticles (MP) suspended in topically applied hydrogels (HEART) establish a sustained chemokine gradient at the injured myocardium. HEART recruits CCR4+ regulatory T cells, reduces infarct size and graft fibrosis, and improves cardiac function.
Matthew A. Borrelli, Alexis T. Reese, Jordan J. P. Warunek, Betsy Ann Varghese, Canxing Lin, Jeffery J. Baust, Brenda McMahon, Steven R. Little, Hēth R. Turnquist   +8 more
wiley   +1 more source

Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis

Respiratory Research
Idiopathic pulmonary fibrosis (IPF) is a high-mortality lung disease with unclear pathogenesis. Convincing evidence suggests that an imbalance in mitochondrial homeostasis resulting from repeated injury to alveolar epithelial type 2 cells (AEC2 ...
Hui Lian, Kai Xu, Airu Chang, Yaxuan Wang, Shuaichen Ma, Lianhui Cheng, Wenyu Zhao, Cong Xia, Lan Wang, Guoying Yu   +9 more
doaj   +1 more source

Mediating effects of physical activity enjoyment on physical activity levels in adults with cystic fibrosis

Frontiers in Sports and Active Living
BackgroundThis study aimed to investigate the mediating effect of physical activity enjoyment (PAE) on various physical activity (PA) levels in adult people with cystic fibrosis (pwCF) concerning disease-specific and non-disease-specific factors.MethodsA
Matthias Welsner, Jin-Sun Schermaul, Jose Guillermo Ortiz, Liron Lechtenberg, Christian Taube, Florian Stehling, Wolfgang Gruber   +6 more
doaj   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source

Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis

Epigenetics & Chromatin
Background Pulmonary fibrosis is a relentless and ultimately fatal lung disorder. Despite a wealth of research, the intricate molecular pathways that contribute to the onset of PF, especially the aspects related to epigenetic modifications and chromatin ...
Zhongzheng Li, Mengke Zhang, Yujie Zhang, Yulong Gan, Zhao Zhu, Jiawei Wang, Yanlin Zhou, Guoying Yu, Lan Wang   +8 more
doaj   +1 more source