Results 101 to 110 of about 789,217 (259)

Transition Planning for Chronic Illnesses in the Time of COVID-19

Journal of Patient Experience, 2020
Transition from pediatric to adult care for those with chronic illnesses must have special considerations during the COVID-19 pandemic. The SARS-CoV-2 coronavirus has significantly disrupted social, economic, and health care practices globally.
William R Hunt MD, Rachel W Linnemann MD, Brandi Middour-Oxler DNP   +2 more
doaj   +1 more source

Macrorheology of cystic fibrosis, chronic obstructive pulmonary disease & normal sputum [PDF]

, 2009
Background Prior microrheologic assessments of selected, microlitre plugs of cystic fibrosis (CF) sputum suggest no intrinsic rheologic abnormality. However, such analyses may not be representative of CF sputum as a whole.
Young Simon A, Serisier David J, Carroll, M., Shute Janis K, Serisier, D., Carroll Mary P, Young, Simon A., Shute, Jan, David J Serisier, Mary P Carroll, Janis K Shute, Simon A Young   +11 more
core   +2 more sources

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA

Nature Communications
Aberrant repair underlies the pathogenesis of pulmonary fibrosis while effective strategies to convert fibrosis to normal regeneration are scarce. Here, we found that thyroid hormone is decreased in multiple models of lung injury but is essential for ...
Xin Pan, Lan Wang, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li, Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng Li, Saiya Guo, Peishuo Yan, Chen Ding, Ivan O. Rosas, Guoying Yu   +16 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Immunobiology of pulmonary fibrosis

Frontiers in Immunology
Pulmonary fibrosis, an interstitial lung disease, is characterized by progressive thickening and scarring of the lung tissue associated with shortness of breath, decreased vital capacity, and respiratory failure due to the inability to expand and contract the lungs during inspiration with severe morbidity and mortality. The median estimated survival is
Bindu, Samik, Yasmin, Hadida, Barman, Uttam, Pandit, Subhradip, Masmoudi, Khaled, Kishore, Uday   +5 more
openaire   +2 more sources

MRI of the lung (3/3)-current applications and future perspectives [PDF]

, 2011
BackgroundMRI of the lung is recommended in a number of clinical indications. Having a non-radiation alternative is particularly attractive in children and young subjects, or pregnant women.MethodsProvided there is sufficient expertise, magnetic ...
M. Both, Molinari, F., Mirsadraee, S., E. J. R. Van Beek, Molinari, F, Both, M, Beer, M., Bauman, G, Wild, J., Mirsadraee, S, Biederer, J, Hintze, C, Jürgen Biederer, J. Wild, S. Mirsadraee, Puderbach, M, Biederer, Jürgen, Wild, J, Bauman, G., M. Beer, M. Puderbach, Van Beek, E J R, Beer, M, Hintze, C., Both, M., G. Bauman, C. Hintze, Van Beek, EJR, F. Molinari, Van Beek, E. J. R., Puderbach, M.   +30 more
core   +2 more sources

Dual‐Targeting Biomimetic Nanozymes Loaded Microneedle Patch Promotes Scarless Wound Healing Through Anti‐Inflammatory and Anti‐Fibrotic Effects

Advanced Science, EarlyView.
This study developed a dual‐targeting biomimetic nanozyme hybrid system (Cu‐CeO2@ABs‐FTP) and integrated it with HAMA hydrogel to fabricate a microneedle patch (CAF@MN). The patch promotes fibroblast‐mediated wound repair, targets macrophages to induce M2 polarization, and targets myofibroblasts to exert anti‐fibrotic effects, thereby enabling rapid ...
Hongyi Zhang, Jinwei Li, Shan Hua, Shengming Wu, Chenlong He, Yuan Zhu, Ming Yin, Han Zhou, Huawei Liu, Chika Hasegawa, Jun Lyu, Keyue Xiao, Hua Jiang, Yilong Wang, Yuxin Qian   +14 more
wiley   +1 more source

Assessing the impact of triiodothyronine treatment on the lung microbiome of mice with pulmonary fibrosis

BMC Pulmonary Medicine
Background Idiopathic pulmonary fibrosis (IPF), an interstitial lung disease, is characterized by the exacerbation of progressive pulmonary fibrosis (PF). IPF primarily affects older individuals and can lead to respiratory failure.
Xiaoshu Guo, Kai Xu, Qiwen Wang, Zongyuan Han, Guoying Yu   +4 more
doaj   +1 more source

Sputum biomarkers and the prediction of clinical outcomes in patients with cystic fibrosis. [PDF]

, 2012
Lung function, acute pulmonary exacerbations (APE), and weight are the best clinical predictors of survival in cystic fibrosis (CF); however, underlying mechanisms are incompletely understood.
Carveth, Holly, William Walsh, Christen Lane, James Moore, Li, Yanping, Jun Chen (4238), Holly Carveth (143299), Carveth Holly, Judy L. Jensen (143284), William Walsh (143288), Anne Sturrock (143317), Liou Theodore G., Robert Paine III (143322), Ruth H. Keogh (143278), Paine, Robert, Teresa Clark (143295), Hoidal, John R, Cox David R., Adler Frederick R., Moore James, Hoidal John R., Shaunessy L. Rogers (143305), Rogers Shaunessy L., David R. Cox (77429), John R. Hoidal (143328), Lane Christen, Ruth H Keogh, Chen, Jun, Packer Kristyn, Kristyn Packer (143291), Frederick R. Adler (143274), Paine Robert, Clark, Teresa, Keogh, Ruth H, Anne Sturrock, Theodore G Liou, David R Cox, Robert Paine, Walsh William, Packer, Kristyn, Jensen, Judy L, Sturrock, Anne, Yanping Li (90163), Sturrock Anne, Kristyn Packer, Shaunessy L Rogers, Frederick R Adler, Rogers, Shaunessy L, Yanping Li, Keogh Ruth H., Chen Jun, Adler, Frederick R, Jun Chen, Liou, Theodore G, Clark Teresa, Theodore G. Liou (143270), Judy L Jensen, John R Hoidal, Li Yanping, Lane, Christen, Christen Lane (143311), Holly Carveth, James Moore (22922), Walsh, William, Teresa Clark, Jensen Judy L., Cox, David R, Moore, James   +67 more
core   +2 more sources