Results 111 to 120 of about 280,725 (312)

Managing comorbidities in idiopathic pulmonary fibrosis [PDF]

, 2015
Blair G Fulton,1 Christopher J Ryerson1,2 1Department of Medicine, 2Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada Abstract: Major risk factors for idiopathic pulmonary fibrosis (IPF) include older age and a ...
Fulton BG, Ryerson CJ
core  

Aging and Pulmonary Fibrosis

Revista de Investigación Clínica, 2016
Idiopathic pulmonary fibrosis is a chronic, progressive, and usually fatal lung disorder of unknown etiology. The disease likely results from the interaction of genetic susceptibility architecture, environmental factors such as smoking, and an abnormal epigenetic reprogramming that leads to a complex pathogenesis.
Moisés, Selman, Ivette, Buendía-Roldán, Annie, Pardo   +2 more
openaire   +2 more sources

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Assessing the impact of triiodothyronine treatment on the lung microbiome of mice with pulmonary fibrosis

BMC Pulmonary Medicine
Background Idiopathic pulmonary fibrosis (IPF), an interstitial lung disease, is characterized by the exacerbation of progressive pulmonary fibrosis (PF). IPF primarily affects older individuals and can lead to respiratory failure.
Xiaoshu Guo, Kai Xu, Qiwen Wang, Zongyuan Han, Guoying Yu   +4 more
doaj   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Elucidating the molecular basis of a novel autosomal dominant fibrotic syndrome [PDF]

, 2009
Includes abstract.Includes bibliographical references (leaves 97-103).A novel fibrotic syndrome was recently reported in a South African family, characterised by poikiloderma, tendon contracture and progressive pulmonary fibrosis.
Watson, Lauren
core  

MRI of the lung (3/3)-current applications and future perspectives [PDF]

, 2011
BackgroundMRI of the lung is recommended in a number of clinical indications. Having a non-radiation alternative is particularly attractive in children and young subjects, or pregnant women.MethodsProvided there is sufficient expertise, magnetic ...
M. Both, Molinari, F., Mirsadraee, S., E. J. R. Van Beek, Molinari, F, Both, M, Beer, M., Bauman, G, Wild, J., Mirsadraee, S, Biederer, J, Hintze, C, Jürgen Biederer, J. Wild, S. Mirsadraee, Puderbach, M, Biederer, Jürgen, Wild, J, Bauman, G., M. Beer, M. Puderbach, Van Beek, E J R, Beer, M, Hintze, C., Both, M., G. Bauman, C. Hintze, Van Beek, EJR, F. Molinari, Van Beek, E. J. R., Puderbach, M.   +30 more
core   +1 more source

GSR Deficiency Exacerbates Oxidative Stress and Promotes Pulmonary Fibrosis

Biomolecules
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder characterized by excessive scarring of lung tissue, predominantly affecting middle-aged and elderly populations.
Wenyu Zhao, Hehe Cao, Wenbo Xu, Yudi Duan, Yulong Gan, Shuang Huang, Ying Cao, Siqi Long, Yingying Zhang, Guoying Yu, Lan Wang   +10 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Right Ventricular Fibrosis: A Pathophysiological Factor in Pulmonary Hypertension? [PDF]

, 2019
The role of right ventricular (RV) fibrosis in pulmonary hypertension (PH) remains a subject of ongoing discussion. Alterations of the collagen network of the extracellular matrix may help prevent ventricular dilatation in the pressure-overloaded RV.
Andersen, Stine, de Man, Frances S., Nielsen-Kudsk, Jens Erik, Vonk Noordegraaf, Anton   +3 more
core   +1 more source