Infrapatellar fat pad fibrosis after anterior cruciate ligament reconstruction is associated with male sex, high body mass index, prolonged operation time and articular cartilage damage, with detrimental effects on one-year clinical outcomes. [PDF]
Yoshida R+11 more
europepmc +1 more source
D‐glucuronyl C5‐Epimerase Binds to EGFR to Suppress Kidney Fibrosis
Glucuronyl C5‐epimerase (Hsepi, gene name Glce) is a key enzyme catalyzing heparan sulfate (HS) chain biosynthesis in HS proteoglycans, which are ubiquitously expressed on cell membranes. In normal renal tubular cells, Glce binds to the intracellular domains of EGFR, maintaining stable and orderly EGFR phosphorylation.
Xiaoqi Jing+9 more
wiley +1 more source
A novel combination therapy with Uridine and Praziquantel effectively alleviates schistosomiasis-induced hepatic fibrosis through promoting adipogenic differentiation. [PDF]
Zhou X+10 more
europepmc +1 more source
An integral functional axis through which GPN and functional metabolites of Alistipes senegalensis can hydrolyze tryptophan into indoles. Furthermore, the Alistipes senegalensis‐indole‐AhR pathway is found to be associated with increased expression of tight junction‐associated proteins and activation of gut stem cells.
Dandan Wang+10 more
wiley +1 more source
Quantitative assessment of mucosal fibrosis and its correlation with disease severity and outcome in cats with chronic enteropathy. [PDF]
Dausend N+5 more
europepmc +1 more source
Homeostasis of Gut Microbiota Protects against Susceptibility to Fungal Pneumonia
Fungal pneumonia induces inflammation, shown by heightened IL‐6, IL‐1β, TNF‐α levels and a growth in Staphylococcus in the alveolar flora. The gut microbiota, acting through the gut‐lung axis via blood, impacts fungal pneumonia susceptibility by altering lung metabolism and inflammatory responses.
Jian Ji+12 more
wiley +1 more source
Post‐Translational Modifications in Cilia and Ciliopathies
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source