Results 331 to 340 of about 1,754,298 (385)

Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway. [PDF]

Commun Biol
Jin Z, Jin Z, Liu Z, Yin Y, Zhang Y, Zhang Y, Kang J, Fang Y, Jiang W, Ning B.   +9 more
europepmc   +1 more source

Orosomucoid 1 Ameliorates Temporomandibular Joint Osteoarthritis by Maintaining Cartilage Homeostasis

Advanced Science, EarlyView.
The present study identified the key protein ORM1 through the proteomic analysis of synovial fluid samples from patients with temporomandibular joint osteoarthritis (TMJOA), and demonstrated the important role of ORM1 in maintaining cartilage homeostasis via the suppression of VIM/MAPK/MMP signalling.
Dahe Zhang, Yuxin Zhang, Simo Xia, Lu Chen, Pei Shen, Chi Yang   +5 more
wiley   +1 more source

Concurrent nonalcoholic fatty liver disease may decrease liver fibrosis severity in patients with primary biliary cholangitis. [PDF]

BMC Gastroenterol
Ren W, Wang Z, Liu X, Liu X, Ma D, Jin Q, Wang J, Feng J, Rao H, Wang X, Huang R.   +10 more
europepmc   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Hepatic stellate cell-specific miR-214 expression alleviates liver fibrosis without boosting steatosis and inflammation. [PDF]

J Transl Med
Zhao F, Niu X, Song G, Wang L, Fu Y, Li S, Gu X, Wang Q, Luo J.   +8 more
europepmc   +1 more source

EphrinB2 alleviates tubulointerstitial fibrosis in diabetic kidney disease. [PDF]

J Transl Med
Ni L, Zhou Q, Gao X, Chen F, Yusufu A, Chen JH, Yuan C, Wu X.   +7 more
europepmc   +1 more source

Insights into the Molecular Mechanisms and Novel Therapeutic Strategies of Stenosis Fibrosis in Crohn's Disease. [PDF]

Biomedicines
Zhou Y, Chen H, Wang Q, Ye G, Ou Y, Huang L, Wu X, Fei J.   +7 more
europepmc   +1 more source