Results 61 to 70 of about 952,925 (309)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Cystic fibrosis [PDF]

, 2004
In the 1930s, when cystic fibrosis (CF) was first clearly recognised, it was a disorder that inevitably led to death in early childhood from respiratory failure and malnutrition.

core  

Nederlandse Cystic Fibrosis Registratie

, 2022
De Nederlandse Cystic Fibrosis Stichting (NCFS) coördineert, beheert en financiert de Nederlandse CF Registratie. Een Stuurgroep samengesteld uit vertegenwoordigers van alle CF-centra en de NCFS bepaalt het beleid rond de NCFR.
Nederlandse Cystic Fibrosis Stichting (NCFS), Nederlandse CF-centra   +1 more
core  

National survey on pediatric respiratory physiotherapy units: primary ciliary dyskinesia and non-CF bronchiectasis

Italian Journal of Pediatrics
Background Currently, there is a lack of data concerning the organization and characteristics of Italian pediatric physiotherapy units for the treatment of patients with chronic lung diseases, especially those with rare conditions such as Primary Ciliary
Beatrice Tani, Nicola Ullmann, Paola Leone, Alessandra Boni, Eugenio Barbieri, Matteo D’Angelo, Sara De Dominicis, Beniamino Giacomodonato, Stefania Monduzzi, Irene Piermarini, Chiara Pizziconi, Beatrice Ferrari, Renato Cutrera   +12 more
doaj   +1 more source

A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion

Nature Communications, 2021
Premature termination codons can cause early translation termination and lead to disease. Here the authors perform a screen to identify compounds with readthrough activity and show that these reduce eRF1 levels to suppress premature termination ...
Jyoti Sharma, Ming Du, Eric Wong, Venkateshwar Mutyam, Yao Li, Jianguo Chen, Jamie Wangen, Kari Thrasher, Lianwu Fu, Ning Peng, Liping Tang, Kaimao Liu, Bini Mathew, Robert J. Bostwick, Corinne E. Augelli-Szafran, Hermann Bihler, Feng Liang, Jerome Mahiou, Josef Saltz, Andras Rab, Jeong Hong, Eric J. Sorscher, Eric M. Mendenhall, Candice J. Coppola, Kim M. Keeling, Rachel Green, Martin Mense, Mark J. Suto, Steven M. Rowe, David M. Bedwell   +29 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

An appraisal of the histopathological assessment of liver fibrosis [PDF]

, 2006
One of the most important aspects of the histopathological assessment of liver biopsies in the setting of chronic liver disease is determination of the degree of fibrosis and architectural change.
Dhillon, A.P., Cholongitas, E., Dhillon, A., Burroughs, A.K., Standish, R.A.   +4 more
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A metagenomic approach to characterize temperate bacteriophage populations from Cystic Fibrosis and non-Cystic Fibrosis bronchiectasis patients [PDF]

, 2015
Pseudomonas aeruginosa (Pa), normally a soil commensal, is an important opportunistic pathogen in Cystic Fibrosis (CF) and non-Cystic Fibrosis Bronchiectasis (nCFBR).
Bourke, Stephen, Smith, Darren L., Anthony eDe Soyza, Cowley, Lauren A., Perry, J. D. (John), Holt, Giles S., Francesca Louise Claire Everest, Stephen eBourke, Darren L. Smith, Tariq, M. A. (Mohammad), Smith, Darren, Stephen eCummings, Holt, Giles, Clare V. Lanyon, Cowley, Lauren, Jeremy J Barr, Bourke, Stephen J., Barr, Jeremy J., Mohammad Adnan Tariq, Bridge, Simon H., Cummings, Stephen, Perry, John, Audrey Perry, Jeremy J. Barr, Barr, Jeremy, Francesca L. C. Everest, Stephen J. Bourke, Bridge, Simon, Simon H. Bridge, Audrey ePerry, Anthony De Soyza, Simon Harwood Bridge, Stephen P. Cummings, John D. Perry, Tariq, Mohammad, Darren Lee Smith, Everest, Francesca, John D Perry, Giles Samuel Holt, Lauren A. Cowley, Lanyon, Clare, Mohammad A. Tariq, Everest, F. L. C. (Francesca), Giles S. Holt, de Soyza, Anthony, Perry, Audrey, Lauren eCowley, Clare Veronica Lanyon   +47 more
core   +1 more source

Hepatic fibrosis [PDF]

Current Opinion in Gastroenterology, 2009
This review will summarize the most significant work that contributed to the understanding of liver fibrosis progression and resolution, which in turn has yielded new areas of therapeutic targeting.Liver fibrosis is the result of an imbalance between production and dissolution of extracellular matrix.
Jingjing, Jiao, Scott L, Friedman, Costica, Aloman   +2 more
openaire   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source