Results 71 to 80 of about 952,925 (309)

Nasal fibrosis: long-term follow up of four cases of eosinophilic angiocentric fibrosis [PDF]

, 2005
Eosinophilic angiocentric fibrosis is a rare, benign cause of submucosal thickening and fibrosis within the upper respiratory tract. It predominantly affects the nose although cases have been reported in the subglottis.
Gallimore, A, Paun, S, Lund, VJ
core  

Differences in disease severity of F508del homozygotes across European countries [PDF]

, 2010
Introduction: Significant phenotypic variation occurs even among patients carrying identical CFTR genotype. This suggests that other factors, such as modifier genes and environmental factors, contribute to the determination of CF severity.
Bossi, A., E. Kerem, H. Olesen, A. Bossi, European Cystic Fibrosis Registry, Olesen, H., A. Zolin, Kerem, E., Viviani, L., L. Viviani, Zolin, A.   +10 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Health economic modelling in Cystic Fibrosis: a systematic review [PDF]

, 2019
INTRODUCTION: Cystic Fibrosis (CF) is a heritable chronic condition. Due to the genetic and progressive nature of CF, a number of interventions are available for the condition.
Sach, Tracey, Carr, Siobhan, Turner, David, Archangelidi, Olga, Bhadhuri, Arjun, Whitty, Jennifer A., Bilton, Diana, Whitty, Jennifer A, Mohindru, Bishal   +8 more
core   +1 more source

Fighting time: A qualitative analysis on the impact of lung transplantation in adults with Cystic Fibrosis [PDF]

, 2001
During the last decade lung transplantation has become an option for those with end-stage respiratory disease, including Cystic Fibrosis. However, there appears to have been very little written about the experiences of those who are on the lung ...
McCarthy, Janet Mary
core   +3 more sources

UK Cystic Fibrosis Registry Website Enhancements: A User-Centred Approach to the Data Access Transparency

International Journal of Population Data Science
Background As a member of the HDR UK Alliance, Cystic Fibrosis Trust is committed to adopting and maintaining the transparency standards within the UK CF Registry (UKCFR).
Poh-Choo Pang, Sarah Clarke
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis

Nature Communications, 2020
The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human and murine
Alison E. John, Rebecca H. Graves, K. Tao Pun, Giovanni Vitulli, Ellen J. Forty, Paul F. Mercer, Josie L. Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, Lloyd I. Bibby, Elaine Gower, Valerie S. Morrison, Yim Man, James A. Roper, Jeni C. Luckett, Lee A. Borthwick, Ben S. Barksby, Rachel A. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, Susan Pyne, Anthony Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, Natasja Stæhr Gudmann, Diana J. Leeming, Rachel C. Chambers, Pauline T. Lukey, Richard P. Marshall, Simon J. F. Macdonald, R. Gisli Jenkins, Robert J. Slack   +36 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Endothelial ferroptosis: a novel mechanism and therapeutic target in diabetic microvascular complications

Molecular Medicine
Diabetic complications, which are grave sequelae of diabetes, are the primary cause of mortality among diabetic individuals. Effective prevention and management of these complications are essential for reducing mortality rates.
Zhongyin Xie, Luxin Li, Yanhui Chu, Yan Wu, Yanan Cao, Lijiao Jin, Haiying Shu, Zhen Zhang   +7 more
doaj   +1 more source