Mechanisms of fibrous cap formation in atherosclerosis [PDF]
Frontiers in Cardiovascular Medicine, 2023 The fibrous cap is formed by smooth muscle cells that accumulate beneath the plaque endothelium. Cap rupture is the main cause of coronary thrombosis, leading to infarction and sudden cardiac death.
Laura Alonso-Herranz +4 more
doaj +6 more sources
Automated analysis of fibrous cap in intravascular optical coherence tomography images of coronary arteries [PDF]
Scientific Reports, 2022 Thin-cap fibroatheroma (TCFA) and plaque rupture have been recognized as the most frequent risk factor for thrombosis and acute coronary syndrome. Intravascular optical coherence tomography (IVOCT) can identify TCFA and assess cap thickness, which ...
Juhwan Lee +11 more
doaj +5 more sources
Tissue-engineered collagenous fibrous cap models to systematically elucidate atherosclerotic plaque rupture [PDF]
Scientific Reports, 2022 A significant amount of vascular thrombotic events are associated with rupture of the fibrous cap that overlie atherosclerotic plaques. Cap rupture is however difficult to predict due to the heterogenous composition of the plaque, unknown material ...
T. B. Wissing +5 more
doaj +10 more sources
Increased Proximal Wall Shear Stress of Basilar Artery Plaques Associated with Ruptured Fibrous Cap [PDF]
Brain Sciences, 2022 Plaque rupture of the basilar artery is one of the leading causes of posterior circulation stroke. The present study aimed to investigate the role of fluid dynamics in the ruptured fibrous cap of basilar artery plaques.
Ruiyun Huang +5 more
doaj +3 more sources
Carotid Plaque Fibrous Cap Thickness Measurement by ARFI Variance of Acceleration: In Vivo Human Results. [PDF]
IEEE Trans Med Imaging, 2020 This study evaluates the performance of an acoustic radiation force impulse (ARFI)-based outcome parameter, the decadic logarithm of the variance of acceleration, or log(VoA), for measuring carotid fibrous cap thickness.
Torres G +5 more
europepmc +4 more sources
A Two-Phase Model of Early Fibrous Cap Formation in Atherosclerosis [PDF]
arXiv, 2018 Atherosclerotic plaque growth is characterised by chronic inflammation that promotes accumulation of cellular debris and extracellular fat in the inner artery wall. This material is highly thrombogenic, and plaque rupture can lead to the formation of blood clots that occlude major arteries and cause myocardial infarction or stroke. In advanced plaques,
M. Watson +3 more
arxiv +8 more sources
Numerical modeling of experimental human fibrous cap delamination. [PDF]
J Mech Behav Biomed Mater, 2016 Fibrous cap delamination is a critical process during the rupture of atherosclerotic plaque, which often leads to severe life-threatening clinical consequences such as myocardial infarction or stroke. In this study a finite element modeling and simulation approach is presented that enables the study of fibrous cap delamination experiments for the ...
Leng X +4 more
europepmc +7 more sources
Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study. [PDF]
Cardiovasc Diabetol, 2017 BackgroundPatients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque.
Milzi A +5 more
europepmc +3 more sources
Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. [PDF]
PLoS Genetics, 2015 Recent genome wide association studies have identified a number of genes that contribute to the risk for coronary heart disease. One such gene, TCF21, encodes a basic-helix-loop-helix transcription factor believed to serve a critical role in the ...
Sylvia T Nurnberg +20 more
doaj +6 more sources
Deep learning segmentation of fibrous cap in intravascular optical coherence tomography images [PDF]
Scientific ReportsThin-cap fibroatheroma (TCFA) is a prominent risk factor for plaque rupture. Intravascular optical coherence tomography (IVOCT) enables identification of fibrous cap (FC), measurement of FC thicknesses, and assessment of plaque vulnerability.
Juhwan Lee +9 more
doaj +5 more sources