Mechanisms of fibrous cap formation in atherosclerosis [PDF]
Frontiers in Cardiovascular Medicine, 2023 The fibrous cap is formed by smooth muscle cells that accumulate beneath the plaque endothelium. Cap rupture is the main cause of coronary thrombosis, leading to infarction and sudden cardiac death.
Laura Alonso-Herranz +4 more
doaj +5 more sources
Tissue-engineered collagenous fibrous cap models to systematically elucidate atherosclerotic plaque rupture [PDF]
Scientific Reports, 2022 A significant amount of vascular thrombotic events are associated with rupture of the fibrous cap that overlie atherosclerotic plaques. Cap rupture is however difficult to predict due to the heterogenous composition of the plaque, unknown material ...
T. B. Wissing +5 more
doaj +9 more sources
Deep learning segmentation of fibrous cap in intravascular optical coherence tomography images [PDF]
Scientific ReportsThin-cap fibroatheroma (TCFA) is a prominent risk factor for plaque rupture. Intravascular optical coherence tomography (IVOCT) enables identification of fibrous cap (FC), measurement of FC thicknesses, and assessment of plaque vulnerability.
Juhwan Lee +9 more
doaj +5 more sources
Increased Proximal Wall Shear Stress of Basilar Artery Plaques Associated with Ruptured Fibrous Cap [PDF]
Brain Sciences, 2022 Plaque rupture of the basilar artery is one of the leading causes of posterior circulation stroke. The present study aimed to investigate the role of fluid dynamics in the ruptured fibrous cap of basilar artery plaques.
Ruiyun Huang +5 more
doaj +2 more sources
Automated analysis of fibrous cap in intravascular optical coherence tomography images of coronary arteries [PDF]
Scientific Reports, 2022 Thin-cap fibroatheroma (TCFA) and plaque rupture have been recognized as the most frequent risk factor for thrombosis and acute coronary syndrome. Intravascular optical coherence tomography (IVOCT) can identify TCFA and assess cap thickness, which ...
Juhwan Lee +11 more
doaj +2 more sources
Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling [PDF]
Frontiers in Cardiovascular Medicine, 2022 Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk.
Laura Martinez-Campesino +14 more
doaj +2 more sources
Monocytes and neutrophils expressing myeloperoxidase occur in fibrous caps and thrombi in unstable coronary plaques [PDF]
BMC Cardiovascular Disorders, 2009 Background Myeloperoxidase (MPO) -containing macrophages and neutrophils have been described at sites of plaque rupture. The presence of these cells in precursor lesions to acute rupture (thin cap atheroma, or vulnerable plaque) and within thrombi ...
Li Ling +3 more
doaj +2 more sources
Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. [PDF]
PLoS Genetics, 2015 Recent genome wide association studies have identified a number of genes that contribute to the risk for coronary heart disease. One such gene, TCF21, encodes a basic-helix-loop-helix transcription factor believed to serve a critical role in the ...
Sylvia T Nurnberg +20 more
doaj +4 more sources
Dysregulation of MMP2-dependent TGF-ß2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis [PDF]
Nature CommunicationsType 2 diabetes is associated with cardiovascular disease, possibly due to impaired vascular fibrous repair. Yet, the mechanisms are elusive. Here, we investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque ...
Pratibha Singh +18 more
doaj +2 more sources
Carotid Plaque Fibrous Cap Thickness Measurement by ARFI Variance of Acceleration: In Vivo Human Results. [PDF]
IEEE Trans Med Imaging, 2020 Torres G +5 more
europepmc +3 more sources