Results 1 to 10 of about 593,549 (321)

Mechanisms of fibrous cap formation in atherosclerosis [PDF]

Frontiers in Cardiovascular Medicine, 2023
The fibrous cap is formed by smooth muscle cells that accumulate beneath the plaque endothelium. Cap rupture is the main cause of coronary thrombosis, leading to infarction and sudden cardiac death.
Laura Alonso-Herranz, Julián Albarrán-Juárez, Jacob Fog Bentzon, Jacob Fog Bentzon, Jacob Fog Bentzon   +4 more
doaj   +6 more sources

Increased Proximal Wall Shear Stress of Basilar Artery Plaques Associated with Ruptured Fibrous Cap [PDF]

Brain Sciences, 2022
Plaque rupture of the basilar artery is one of the leading causes of posterior circulation stroke. The present study aimed to investigate the role of fluid dynamics in the ruptured fibrous cap of basilar artery plaques.
Ruiyun Huang, Hongbing Chen, Chenghao Li, Chaowei Lie, Zhihua Qiu, Yongjun Jiang   +5 more
doaj   +5 more sources

Deep learning segmentation of fibrous cap in intravascular optical coherence tomography images [PDF]

Scientific Reports, 2023
Thin-cap fibroatheroma (TCFA) is a prominent risk factor for plaque rupture. Intravascular optical coherence tomography (IVOCT) enables identification of fibrous cap (FC), measurement of FC thicknesses, and assessment of plaque vulnerability.
Juhwan Lee, Justin N. Kim, Luis A. P. Dallan, Vladislav N. Zimin, Ammar Hoori, Neda S. Hassani, Mohamed H. E. Makhlouf, Giulio Guagliumi, Hiram G. Bezerra, David L. Wilson   +9 more
doaj   +7 more sources

Tissue-engineered collagenous fibrous cap models to systematically elucidate atherosclerotic plaque rupture [PDF]

Scientific Reports, 2022
A significant amount of vascular thrombotic events are associated with rupture of the fibrous cap that overlie atherosclerotic plaques. Cap rupture is however difficult to predict due to the heterogenous composition of the plaque, unknown material ...
T. B. Wissing, K. Van der Heiden, S. M. Serra, A. I. P. M. Smits, C. V. C. Bouten, F. J. H. Gijsen   +5 more
doaj   +9 more sources

Automated analysis of fibrous cap in intravascular optical coherence tomography images of coronary arteries [PDF]

Scientific Reports, 2022
Thin-cap fibroatheroma (TCFA) and plaque rupture have been recognized as the most frequent risk factor for thrombosis and acute coronary syndrome. Intravascular optical coherence tomography (IVOCT) can identify TCFA and assess cap thickness, which ...
Juhwan Lee, Gabriel T. R. Pereira, Yazan Gharaibeh, Chaitanya Kolluru, Vladislav N. Zimin, Luis A. P. Dallan, Justin N. Kim, Ammar Hoori, Sadeer G. Al-Kindi, Giulio Guagliumi, Hiram G. Bezerra, David L. Wilson   +11 more
doaj   +4 more sources

Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling [PDF]

Frontiers in Cardiovascular Medicine, 2022
Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk.
Laura Martinez-Campesino, Klaudia Kocsy, Jaime Cañedo, Jessica M. Johnston, Charlotte E. Moss, Simon A. Johnston, Stephen Hamby, Stephen Hamby, Alison H. Goodall, Alison H. Goodall, Jessica Redgrave, Sheila E. Francis, Endre Kiss-Toth, Endre Kiss-Toth, Heather L. Wilson   +14 more
doaj   +3 more sources

Clinical Significance of the Presence or Absence of Lipid-Rich Plaque Underneath Intact Fibrous Cap Plaque in Acute Coronary Syndrome. [PDF]

J Am Heart Assoc, 2019
Background Although most coronary thromboses occur on the surface of lipid‐rich plaque (LRP) with plaque rupture (PR), previous pathological and optical coherence tomography studies demonstrated diversity in the morphological characteristics of culprit ...
Hoshino M, Yonetsu T, Usui E, Kanaji Y, Ohya H, Sumino Y, Yamaguchi M, Hada M, Hamaya R, Kanno Y, Murai T, Lee T, Kakuta T.   +12 more
europepmc   +3 more sources

A pro-inflammatory and fibrous cap thinning transcriptome profile accompanies carotid plaque rupture leading to stroke. [PDF]

Sci Rep, 2022
Atherosclerotic plaque rupture is the etiology of ischemic stroke and myocardial infarction. The molecular mechanisms responsible for rupture remain unclear, in part, due to the lack of data from plaques at the time of rupture.
Bazan HA, Brooks AJ, Vongbunyong K, Tee C, Douglas HF, Klingenberg NC, Woods TC.   +6 more
europepmc   +4 more sources

Dysregulation of MMP2-dependent TGF-ß2 activation impairs fibrous cap formation in type 2 diabetes-associated atherosclerosis [PDF]

Nature Communications
Type 2 diabetes is associated with cardiovascular disease, possibly due to impaired vascular fibrous repair. Yet, the mechanisms are elusive. Here, we investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque ...
Pratibha Singh, Jiangming Sun, Michele Cavalera, Dania Al-Sharify, Frank Matthes, Mohammad Barghouth, Christoffer Tengryd, Pontus Dunér, Ana Persson, Lena Sundius, Mihaela Nitulescu, Eva Bengtsson, Sara Rattik, Daniel Engelbertsen, Marju Orho-Melander, Jan Nilsson, Claudia Monaco, Isabel Goncalves, Andreas Edsfeldt   +18 more
doaj   +3 more sources

Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap. [PDF]

PLoS Genetics, 2015
Recent genome wide association studies have identified a number of genes that contribute to the risk for coronary heart disease. One such gene, TCF21, encodes a basic-helix-loop-helix transcription factor believed to serve a critical role in the ...
Sylvia T Nurnberg, Karen Cheng, Azad Raiesdana, Ramendra Kundu, Clint L Miller, Juyong B Kim, Komal Arora, Ivan Carcamo-Oribe, Yiqin Xiong, Nikhil Tellakula, Vivek Nanda, Nikitha Murthy, William A Boisvert, Ulf Hedin, Ljubica Perisic, Silvia Aldi, Lars Maegdefessel, Milos Pjanic, Gary K Owens, Michelle D Tallquist, Thomas Quertermous   +20 more
doaj   +6 more sources