Type 2 diabetes mellitus is associated with a lower fibrous cap thickness but has no impact on calcification morphology: an intracoronary optical coherence tomography study. [PDF]
Cardiovasc Diabetol, 2017 BackgroundPatients with type 2 diabetes (T2DM) are at high risk for cardiovascular events, which usually arise from the rupture of a vulnerable coronary plaque.
Milzi A +5 more
europepmc +3 more sources
Plaque geometry: determinant for fibrous cap stress levels [PDF]
Journal of Cardiovascular Magnetic Resonance, 2011 In clinical practice, the risk of cerebrovascular events originating from carotid atherosclerotic plaques is correlated to the degree of luminal narrowing, commonly designated the degree of stenosis. Though the degree of stenosis is a proven marker of plaque vulnerability, it is widely recognized that better risk markers for cerebrovascular events are ...
Klærke Anette +6 more
doaj +5 more sources
Numerical modeling of experimental human fibrous cap delamination. [PDF]
J Mech Behav Biomed Mater, 2016 Fibrous cap delamination is a critical process during the rupture of atherosclerotic plaque, which often leads to severe life-threatening clinical consequences such as myocardial infarction or stroke. In this study a finite element modeling and simulation approach is presented that enables the study of fibrous cap delamination experiments for the ...
Leng X +4 more
europepmc +6 more sources
Clinical value of atherosclerotic plaque fibrous cap integrity observed by ultrasound
Chinese Journal of Contemporary Neurology and Neurosurgery, 2014 Objective To retrospectively analyze carotid ultrasonography detection results in patients with unilateral anterior circulation acute ischemic stroke, and to observe the influence of atherosclerotic plaque fibrous cap integrity on plaque stability ...
De-lin YU, Ping MA, Bin LIU, Yi ZHANG
doaj +2 more sources
SGLT2-inhibitors effects on the coronary fibrous cap thickness and MACEs in diabetic patients with inducible myocardial ischemia and multi vessels non-obstructive coronary artery stenosis. [PDF]
Cardiovasc Diabetol, 2023 Background Sodium–glucose transporter 2 inhibitors (SGLT2-I) could modulate atherosclerotic plaque progression, via down-regulation of inflammatory burden, and lead to reduction of major adverse cardiovascular events (MACEs) in type 2 diabetes mellitus ...
Sardu C +14 more
europepmc +2 more sources
Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms. [PDF]
Nat Metab, 2021 Stable atherosclerotic plaques are characterized by a thick, extracellular matrix-rich fibrous cap populated by protective ACTA2+ myofibroblast (MF)-like cells, assumed to be almost exclusively derived from smooth muscle cells (SMCs).
Newman AAC +16 more
europepmc +2 more sources
A two-phase model of early fibrous cap formation in atherosclerosis [PDF]
Journal of Theoretical Biology, 2018 Atherosclerotic plaque growth is characterised by chronic inflammation that promotes accumulation of cellular debris and extracellular fat in the inner artery wall. This material is highly thrombogenic, and plaque rupture can lead to the formation of blood clots that occlude major arteries and cause myocardial infarction or stroke. In advanced plaques,
Michael G. Watson +3 more
semanticscholar +8 more sources
The fibrous cap: a promising target in the pharmacotherapy of atherosclerosis
Biomedical Reviews, 2019 Recent advances have shed light on the relationship between smooth muscle cell (SMC) phenotypic modulation, resolution of inflammation and atherosclerotic plaque stability.
Stanislav Yanev +2 more
semanticscholar +3 more sources
MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions [PDF]
Circulation Research, 2016 Rationale: In the search for markers and modulators of vascular disease, microRNAs (miRNAs) have emerged as potent therapeutic targets. Objective: To investigate miRNAs of clinical interest in patients with unstable carotid ...
Suzanne M. Eken +23 more
semanticscholar +5 more sources
Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study. [PDF]
Eur Heart J, 2020 AIMS Acute coronary syndromes with intact fibrous cap (IFC-ACS), i.e. caused by coronary plaque erosion, account for approximately one-third of ACS. However, the underlying pathophysiological mechanisms as compared with ACS caused by plaque rupture (RFC ...
Leistner DM +25 more
europepmc +2 more sources