Results 11 to 20 of about 539,731 (302)

Fusion of fibrous cap thickness and wall shear stress to assess plaque vulnerability in coronary arteries: a pilot study. [PDF]

Int J Comput Assist Radiol Surg, 2016
PurposeIdentification of rupture-prone plaques in coronary arteries is a major clinical challenge. Fibrous cap thickness and wall shear stress are two relevant image-based risk factors, but these two parameters are generally computed and analyzed ...
Zahnd G, Schrauwen J, Karanasos A, Regar E, Niessen W, van Walsum T, Gijsen F.   +6 more
europepmc   +4 more sources

SGLT2-inhibitors effects on the coronary fibrous cap thickness and MACEs in diabetic patients with inducible myocardial ischemia and multi vessels non-obstructive coronary artery stenosis. [PDF]

Cardiovasc Diabetol, 2023
Background Sodium–glucose transporter 2 inhibitors (SGLT2-I) could modulate atherosclerotic plaque progression, via down-regulation of inflammatory burden, and lead to reduction of major adverse cardiovascular events (MACEs) in type 2 diabetes mellitus ...
Sardu C, Trotta MC, Sasso FC, Sacra C, Carpinella G, Mauro C, Minicucci F, Calabrò P, D' Amico M, D' Ascenzo F, De Filippo O, Iannaccone M, Pizzi C, Paolisso G, Marfella R.   +14 more
europepmc   +2 more sources

Multiple cell types contribute to the atherosclerotic lesion fibrous cap by PDGFRβ and bioenergetic mechanisms. [PDF]

Nat Metab, 2021
Stable atherosclerotic plaques are characterized by a thick, extracellular matrix-rich fibrous cap populated by protective ACTA2+ myofibroblast (MF)-like cells, assumed to be almost exclusively derived from smooth muscle cells (SMCs).
Newman AAC, Serbulea V, Baylis RA, Shankman LS, Bradley X, Alencar GF, Owsiany K, Deaton RA, Karnewar S, Shamsuzzaman S, Salamon A, Reddy MS, Guo L, Finn A, Virmani R, Cherepanova OA, Owens GK.   +16 more
europepmc   +2 more sources

Imaging and analysis of microcalcifications and lipid/necrotic core calcification in fibrous cap atheroma. [PDF]

Int J Cardiovasc Imaging, 2015
The presence of microcalcifications (µCalcs) >5 µm within the cap of human fibroatheroma has been shown to produce a 200-700% increase in peak circumferential stress, which can transform a stable plaque into a vulnerable one, whereas µCalcs < 5 µm do not appear to increase risk. We quantitatively examine the possibility to distinguish caps with µCalcs >
Maldonado N, Kelly-Arnold A, Laudier D, Weinbaum S, Cardoso L.   +4 more
europepmc   +6 more sources

Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling [PDF]

Frontiers in Cardiovascular Medicine, 2022
Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk.
Laura Martinez-Campesino, Klaudia Kocsy, Jaime Cañedo, Jessica M. Johnston, Charlotte E. Moss, Simon A. Johnston, Stephen Hamby, Stephen Hamby, Alison H. Goodall, Alison H. Goodall, Jessica Redgrave, Sheila E. Francis, Endre Kiss-Toth, Endre Kiss-Toth, Heather L. Wilson   +14 more
doaj   +2 more sources

Differential immunological signature at the culprit site distinguishes acute coronary syndrome with intact from acute coronary syndrome with ruptured fibrous cap: results from the prospective translational OPTICO-ACS study. [PDF]

Eur Heart J, 2020
AIMS Acute coronary syndromes with intact fibrous cap (IFC-ACS), i.e. caused by coronary plaque erosion, account for approximately one-third of ACS. However, the underlying pathophysiological mechanisms as compared with ACS caused by plaque rupture (RFC ...
Leistner DM, Kränkel N, Meteva D, Abdelwahed YS, Seppelt C, Stähli BE, Rai H, Skurk C, Lauten A, Mochmann HC, Fröhlich G, Rauch-Kröhnert U, Flores E, Riedel M, Sieronski L, Kia S, Strässler E, Haghikia A, Dirks F, Steiner JK, Mueller DN, Volk HD, Klotsche J, Joner M, Libby P, Landmesser U.   +25 more
europepmc   +2 more sources

Clinical Significance of the Presence or Absence of Lipid-Rich Plaque Underneath Intact Fibrous Cap Plaque in Acute Coronary Syndrome. [PDF]

J Am Heart Assoc, 2019
Background Although most coronary thromboses occur on the surface of lipid‐rich plaque (LRP) with plaque rupture (PR), previous pathological and optical coherence tomography studies demonstrated diversity in the morphological characteristics of culprit ...
Hoshino M, Yonetsu T, Usui E, Kanaji Y, Ohya H, Sumino Y, Yamaguchi M, Hada M, Hamaya R, Kanno Y, Murai T, Lee T, Kakuta T.   +12 more
europepmc   +2 more sources

Plaque geometry: determinant for fibrous cap stress levels [PDF]

Journal of Cardiovascular Magnetic Resonance, 2011
In clinical practice, the risk of cerebrovascular events originating from carotid atherosclerotic plaques is correlated to the degree of luminal narrowing, commonly designated the degree of stenosis. Though the degree of stenosis is a proven marker of plaque vulnerability, it is widely recognized that better risk markers for cerebrovascular events are ...
Klærke Anette, Eldrup Nikolaj, Niemann Anders K, Nygaard Jens V, Thrysøe Samuel A, Paaske William P, Kim Won Y   +6 more
doaj   +4 more sources

Carotid Plaque Lipid Content and Fibrous Cap Status Predict Systemic CV Outcomes: The MRI Substudy in AIM-HIGH. [PDF]

JACC Cardiovasc Imaging, 2017
Sun J, Zhao XQ, Balu N, Neradilek MB, Isquith DA, Yamada K, Cantón G, Crouse JR, Anderson TJ, Huston J, O'Brien K, Hippe DS, Polissar NL, Yuan C, Hatsukami TS.   +14 more
europepmc   +4 more sources

Mitochondrial Respiration Is Reduced in Atherosclerosis, Promoting Necrotic Core Formation and Reducing Relative Fibrous Cap Thickness. [PDF]

Arterioscler Thromb Vasc Biol, 2017
Objective— Mitochondrial DNA (mtDNA) damage is present in murine and human atherosclerotic plaques. However, whether endogenous levels of mtDNA damage are sufficient to cause mitochondrial dysfunction and whether decreasing mtDNA damage and improving ...
Yu EPK, Reinhold J, Yu H, Starks L, Uryga AK, Foote K, Finigan A, Figg N, Pung YF, Logan A, Murphy MP, Bennett M.   +11 more
europepmc   +2 more sources