The fibrous cap: a promising target in the pharmacotherapy of atherosclerosis
Biomedical Reviews, 2019 Recent advances have shed light on the relationship between smooth muscle cell (SMC) phenotypic modulation, resolution of inflammation and atherosclerotic plaque stability.
S. Yanev +2 more
semanticscholar +3 more sources
Monocytes and neutrophils expressing myeloperoxidase occur in fibrous caps and thrombi in unstable coronary plaques [PDF]
BMC Cardiovascular Disorders, 2009 Background Myeloperoxidase (MPO) -containing macrophages and neutrophils have been described at sites of plaque rupture. The presence of these cells in precursor lesions to acute rupture (thin cap atheroma, or vulnerable plaque) and within thrombi ...
Li Ling +3 more
doaj +2 more sources
Association of Age and Size of Carotid Artery Intraplaque Hemorrhage and Minor Fibrous Cap Disruption: A High Resolution Magnetic Resonance Imaging Study. [PDF]
J Atheroscler Thromb, 2018 Aim: To investigate the association between the volumes of different aging intraplaque hemorrhage (IPH) and minor fibrous cap disruption (MFCD) in carotid arteries.
Cui Y +7 more
europepmc +2 more sources
MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions [PDF]
Circulation Research, 2017 Rationale: In the search for markers and modulators of vascular disease, microRNAs (miRNAs) have emerged as potent therapeutic targets. Objective: To investigate miRNAs of clinical interest in patients with unstable carotid stenosis at risk of stroke ...
Suzanne M. Eken +23 more
semanticscholar +4 more sources
Fibrous Cap Thickness by Optical Coherence Tomography In Vivo.
Journal of the American College of Cardiology, 2017 Optical coherence tomography (OCT) imaging is considered to be the only imaging modality with sufficient resolution to measure fibrous cap thickness (FCT) in vivo. However, reproducibility of the measurements in vivo has been unsatisfactory.The authors aimed to investigate whether satisfactory reproducibility of FCT measurements by OCT in vivo can be ...
A. Kini +10 more
semanticscholar +4 more sources
Plaque rupture and intact fibrous cap assessed by optical coherence tomography portend different outcomes in patients with acute coronary syndrome. [PDF]
European Heart Journal, 2015 AIMS Patients presenting with acute coronary syndrome (ACS) may have different plaque morphologies at the culprit lesion. In particular, plaque rupture (PR) has been shown as the more frequent culprit plaque morphology in ACS.
G. Niccoli +12 more
semanticscholar +2 more sources
On the Feasibility of Quantifying Fibrous Cap Thickness With Acoustic Radiation Force Impulse (ARFI) Ultrasound. [PDF]
IEEE Trans Ultrason Ferroelectr Freq Control, 2016 Acute cerebrovascular accidents are associated with the rupture of vulnerable atherosclerotic plaques in the carotid arteries. Fibrous cap (FC) thickness has been shown to be an important predictor of plaque rupture but has been challenging to measure ...
Czernuszewicz TJ, Gallippi CM.
europepmc +2 more sources
Molecular Markers, Fibrous Cap Rupture, and the Vulnerable Plaque [PDF]
Circulation Research, 2001 The study by Faber et al1 in this issue of Circulation Research uses subtraction suppression hybridization (SSH) to identify genes specific to the ruptured atherosclerotic plaque. This article may represent the early days in the oncoming studies of advanced atherosclerosis, a surprisingly neglected area of study.
Stephen M. Schwartz +2 more
openaire +3 more sources
Matrix vesicles in the fibrous cap of atherosclerotic plaque: possible contribution to plaque rupture [PDF]
Journal of Cellular and Molecular Medicine, 2008 AbstractPlaque rupture is the most common type of plaque complication and leads to acute ischaemic events such as myocardial infarction and stroke. Calcification has been suggested as a possible indicator of plaque instability. Although the role of matrix vesicles in the initial stages of arterial calcification has been recognized, no studies have yet ...
Reginald S. A. Lord +3 more
openaire +4 more sources
Circulation Journal, 2019 BACKGROUND Statin therapy has been shown to result in coronary plaque regression, but the relationship between statin use and stabilization of coronary plaque has not been elucidated.
Y. Ozaki +6 more
semanticscholar +3 more sources