Results 31 to 40 of about 56,341 (133)

Fibrous Caps in Atherosclerosis Form by Notch-Dependent Mechanisms Common to Arterial Media Development [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2020
Objective: Atheromatous fibrous caps are produced by smooth muscle cells (SMCs) that are recruited to the subendothelial space. We tested whether the recruitment mechanisms are the same as in embryonic artery development, which relies prominently on Notch signaling to form the subendothelial medial SMC layers.
Donal MacGrogan, Laura Carramolino, Jacob F. Bentzon, Jacob F. Bentzon, Jacob F. Bentzon, Carlos J Martos-Rodríguez, Ainoa Caballero, Ainoa Caballero, José Luis de la Pompa, Julián Albarrán-Juárez, Daniel Morales-Cano   +10 more
openaire   +6 more sources

A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling [PDF]

, 2010
In this study, we investigated a clinically relevant model of in vivo ectopic bone formation utilizing human periosteum derived cells (HPDCs) seeded in a Collagraft carrier and explored the mechanisms by which this process is driven.
Eyckmans, Jeroen, Luyten, F. P., Roberts, S. J., Schrooten, J.   +3 more
core   +1 more source

Orthopedic surgery increases atherosclerotic lesions and necrotic core area in ApoE-/- mice [PDF]

, 2016
Background and aims Observational studies show a peak incidence of cardiovascular events after major surgery. For example, the risk of myocardial infarction increases 25-fold early after hip replacement.
Chen, Cohen, Corrales-Medina, Dutta, Dutta, Gualandro, Hans W.M. Niessen, Hanson, Ilse P.A. Zethof, Janssen, Kaynar, King, Kleemann, Lalmohamed, Landesberg, Lars F.H. Theyse, Libby, Martine C. Morrison, Moore, Morrison, Naghavi, Paul A.J. Krijnen, Reid, Rianne van der Linden, Robert Kleemann, Santos-Gallego, Santos-Gallego, Santos-Gallego, Seimon, Smeeth, Tan, Thompson, Thompson, Van der Donckt, van Dijk, Virmani, Virmani, Wessel W. Fuijkschot, Yvo M. Smulders, Zhang   +39 more
core   +1 more source

Implication of Plaque Color Classification for Assessing Plaque Vulnerability A Coronary Angioscopy and Optical Coherence Tomography Investigation [PDF]

ObjectivesThe purpose of this study was to assess the relationship between plaque color evaluated by coronary angioscopy and fibrous cap thickness estimated by optical coherence tomography (OCT) in vivo.BackgroundYellow color intensity of coronary plaque
Akasaka, Takashi, Imanishi, Toshio, Kitabata, Hironori, Kubo, Takashi, Kuroi, Akio, Masho, Takashi, Matsuo, Yoshiki, Mizukoshi, Masato, Nakamura, Nobuo, Takarada, Shigeho, Tanaka, Atsushi, Tanimoto, Takashi, Tomobuchi, Yoshiaki, Ueno, Satoshi, Yamano, Takashi   +14 more
core   +1 more source

Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions [PDF]

Molecular Therapy, 2018
miRNAs are potential regulators of carotid artery stenosis and concordant vulnerable atherosclerotic plaques. Hence, we analyzed miRNA expression in laser captured micro-dissected fibrous caps of either ruptured or stable plaques (n = 10 each), discovering that miR-21 was significantly downregulated in unstable lesions.
Hans-Henning Eckstein, Daniel Y. Li, Maja Jagodic, Albert Busch, Jaroslav Pelisek, Nancy Simon, Lars Maegdefessel, Lars Maegdefessel, Changyan Sun, Hanna Winter, Ewa Ehrenborg, Greg Winski, Uwe Raaz, Ekaterina Chernogubova, Peter Saliba-Gustafsson, Suzanne M Eken, Hong Jin, Isabel N. Schellinger, Ulf Hedin, Renate Hegenloh, Ljubica Perisic Matic, Alexandra Bäcklund   +21 more
openaire   +5 more sources

Reproducibility of In Vivo Measurements for Fibrous Cap Thickness and Lipid Arc by OCT

JACC: Cardiovascular Imaging, 2012
Thin fibrous cap and lipid pool are thought to be major determinants of plaque instability. However, current imaging modalities such as angiography, intravascular ultrasound, and angioscopy do not have sufficient resolution to accurately measure them.
Koji Kato, Ik-Kyung Jang, Taishi Yonetsu, Hang Lee, Soo-Joong Kim, Shaosong Zhang, Lei Xing   +6 more
openaire   +3 more sources

Mathematical models for vulnerable plaques [PDF]

, 2009
A plaque is an accumulation and swelling in the artery walls and typically consists of cells, cell debris, lipids, calcium deposits and fibrous connective tissue.
Bell, J., Breward, C., Chou, T., Fok, P.-W., Haugh, J. M., Li, Q., Rossi, L., Walter, A., Yang, X., Zemlyanova, A., Zhang, N.   +10 more
core  

Optical Coherence Tomography after Carotid Stenting: Rate of Stent Malapposition, Plaque Prolapse and Fibrous Cap Rupture According to Stent Design [PDF]

, 2013
ObjectivesThis study aims to evaluate the rate of stent malapposition, plaque prolapse and fibrous cap rupture detected by optical coherence tomography (OCT) imaging according to carotid stent design.DesignIt was a prospective single-centre study ...
Cappelli, A., de Donato, G., Galzerano, G., Setacci, C., Setacci, F., Sirignano, P.   +5 more
core   +1 more source

OCT-Based Diagnosis and Management of STEMI Associated With Intact Fibrous Cap

JACC: Cardiovascular Imaging, 2013
In autopsy studies, at least 25% of thrombotic coronary occlusions are caused by plaque erosion in which thrombus often overlies atherosclerotic plaque without evident disruption of the fibrous cap. We performed optical coherence tomography imaging after aspiration thrombectomy and identified plaque erosion as the cause in 31 patients presenting with ...
Jagat Narula, Shiro Uemura, Luca Di Vito, Géraud Souteyrand, Pascal Motreff, Jonathan L. Halperin, Valentin Fuster, Valentin Fuster, Yukio Ozaki, Giuseppe Biondi-Zoccai, Francesco Prati, Renu Virmani   +11 more
openaire   +4 more sources

Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation

EMBO Molecular Medicine, 2012
AbstractAtherosclerotic lesions are asymmetric focal thickenings of the intima of arteries that consist of lipids, various cell types and extracellular matrix (ECM). These lesions lead to vascular occlusion representing the most common cause of death in the Western world.
Jan Nilsson, Pontus Dunér, Eloi Montanez, Eloi Montanez, Karsten Beckmann, Ina Rohwedder, Eva Bengtsson, Reinhard Fässler, Oliver Soehnlein   +8 more
openaire   +4 more sources