Results 51 to 60 of about 21,222 (268)
Local Delivery of miR-21 Stabilizes Fibrous Caps in Vulnerable Atherosclerotic Lesions [PDF]
Molecular Therapy, 2018 miRNAs are potential regulators of carotid artery stenosis and concordant vulnerable atherosclerotic plaques. Hence, we analyzed miRNA expression in laser captured micro-dissected fibrous caps of either ruptured or stable plaques (n = 10 each), discovering that miR-21 was significantly downregulated in unstable lesions.
Hans-Henning Eckstein +21 more
openaire +5 more sources
Molecular Oncology, EarlyView.Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo +11 more
wiley +1 more source
Iranian Journal of Public Health, 2019 Background: To investigate the characterizations of CT (computed tomography) and MRI (magnetic resonance imaging) in patients with carotid atherosclerosis.
Jiangfeng ZHOU +4 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 BACKGROUND Vascular healing response associated with adjunctive n‐3 polyunsaturated fatty acid therapy therapy in patients receiving strong statin therapy remains unclear.
Yoko Kita +13 more
doaj +1 more source
APL Bioengineering, 2023 Rupture of the cap of an atherosclerotic plaque can lead to thrombotic cardiovascular events. It has been suggested, through computational models, that the presence of microcalcifications in the atherosclerotic cap can increase the risk of cap rupture ...
Imke Jansen +7 more
doaj +1 more source
Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives This ongoing, open‐label extension study is evaluating the long‐term safety, tolerability, and efficacy of givinostat, a Class I and II histone deacetylase inhibitor, in patients with Duchenne muscular dystrophy (DMD). Methods The recruited patients completed one of two prior clinical studies (one Phase 2 and one Phase 3 [EPIDYS ...
Craig M. McDonald +74 more
wiley +1 more source
Reproducibility of In Vivo Measurements for Fibrous Cap Thickness and Lipid Arc by OCT
JACC: Cardiovascular Imaging, 2012 Thin fibrous cap and lipid pool are thought to be major determinants of plaque instability. However, current imaging modalities such as angiography, intravascular ultrasound, and angioscopy do not have sufficient resolution to accurately measure them.
Koji Kato +6 more
openaire +3 more sources
Advanced Biology, EarlyView.This study develops a tissue‐engineered model of the atherosclerotic cap using human mesenchymal stromal cells (MSCs). After 2 weeks of culture to produce a collagenous matrix, a mineralizing medium induces microcalcifications over 4 weeks. These constructs, imaged with second harmonic generation microscopy, lead to reduced ultimate stress at rupture ...
Imke L. Jansen +4 more
wiley +1 more source
A robust rabbit model of human atherosclerosis and atherothrombosis[S]
Journal of Lipid Research, 2009 Disruption and thrombosis of atherosclerotic plaques cause most acute cardiovascular events, but their systematic study has been hampered by the lack of suitable animal models.
Alkystis Phinikaridou +3 more
doaj +1 more source
Role of Intracoronary Imaging in Acute Coronary Syndromes
US Cardiology Review, 2022 Intravascular imaging with optical coherence tomography (OCT) and intravascular ultrasound provides superior visualization of the culprit plaques for acute coronary syndromes (ACS) compared with coronary angiography.
Gregory Petrossian +8 more
doaj +1 more source