Results 31 to 40 of about 298,062 (215)

Activation of RANK/RANKL/OPG Pathway Is Involved in the Pathophysiology of Fibrous Dysplasia and Associated With Disease Burden

Journal of Bone and Mineral Research, 2018
Fibrous dysplasia of bone (FD) is a mosaic disease caused by mutations in GNAS. Constitutive activation of the α‐subunit of the Gs stimulatory protein (Gαs) leads to dysregulated proliferation of bone marrow stromal cells (BMSCs), generating expansile ...
L. F. de Castro, A. Burke, Howard D Wang, J. Tsai, P. Florenzano, Kristen S. Pan, N. Bhattacharyya, A. Boyce, R. Gafni, A. Molinolo, P. Robey, M. Collins   +11 more
semanticscholar   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

A Mazabraud’s syndrome: the rare coexistence of fibrous dysplasia and intramuscular myxoma. A case repot [PDF]

Chirurgia Narządów Ruchu i Ortopedia Polska
Mazabraud’s syndrome is a rare, benign skeletal disorder characterized by the coexistence of fibrous dysplasia and intramuscular myxoma. Genetic factors have been implicated in its aetiology.
Ezel Yaltırık Bilgin, Elif Aktaş, Erkan Bilgin   +2 more
doaj   +1 more source

Loss of Stat3 in Prx1+ Progenitors Impairs Molar Root Development

Advanced Biology, EarlyView.
Stat3 critically regulates mandibular first molar and alveolar bone morphogenesis. Conditional ablation of Stat3 disrupts the osteogenic capacity of Prx1+ mesenchymal progenitors, as evidenced across in vivo and in vitro models. Abstract Signal Transducer and Activator of Transcription 3 (Stat3) acts as a central transcriptional modulator coordinating ...
Xin Feng, Wangyu Luo, Yichen Yao, Lichieh Lin, Laiting Chan, Jiarui Lu, Zijing Huang, Jingyi Feng, Le Zhao, Xiaolei Zhang, Liu Yang   +10 more
wiley   +1 more source

Tibial fibrous dysplasia in children treated by Ilizarov technique – a review of treatment options

Гений oртопедии, 2021
Fibrous dysplasia is a pathological condition, where normal medullary bone is replaced by fibrous tissue and small woven specules of bone. Fibrous dysplasia can occur in epiphysis, metaphysis or diaphysis.
Mofakhkharul M. Bari, Islam Shahidul, Ashraf Tanvir, A.M. Shayan R. Bari   +3 more
doaj   +1 more source

Pain in fibrous dysplasia: relationship with anatomical and clinical features

Acta Orthopaedica, 2019
Background and purpose — Fibrous dysplasia (FD) is a rare bone disorder associated with pain, deformities, and pathological fractures. The pathophysiological mechanism of FD-related pain remains ill-understood.
B. Majoor, Eva Traunmueller, W. Maurer-Ertl, Natasha M. Appelman-Dijkstra, Andrea Fink, B. Liegl, N. Hamdy, P. D. Sander Dijkstra, A. Leithner   +8 more
semanticscholar   +1 more source

Advancing Clinical Medicine with Raman Spectroscopy: Current Trends and Future Perspectives

Advanced Photonics Research, EarlyView.
Raman spectroscopy and microscopy may become excellent tools in clinical medicine, including hematology, oncology, infectious diseases, neurology, gastroenterology, reproductive medicine, rheumatology, and cardiovascular research. However, many challenges such as signal interference, standardization issues, and limited clinical application need to be ...
Jiří Bufka, Lenka Vaňková, Josef Sýkora, Věra Křížková, Jan Schwarz, Petr Bouř   +5 more
wiley   +1 more source

18F‐NaF PET/CT IMAGING IN FIBROUS DYSPLASIA OF BONE

Journal of Bone and Mineral Research, 2019
Fibrous dysplasia (FD) is a mosaic skeletal disorder resulting in fractures, deformity, and functional impairment. Clinical evaluation has been limited by a lack of surrogate endpoints capable of quantitating disease activity.
G. Papadakis, Georgios C. Manikis, A. Karantanas, P. Florenzano, Ulas Bagci, K. Marias, M. Collins, A. Boyce   +7 more
semanticscholar   +1 more source

Microfilament‐Myosin II Regulates the Differentiation of Multinucleated Cysts into Oocytes and Influences Oocyte Developmental Potential in Mice

Advanced Science, EarlyView.
In this study, we provided new evidence identifying multinucleated cysts as precursors for oocyte differentiation. Within these cysts, organelles migrate and aggregate to form Balbiani body (B‐body) and establish early cellular polarity. Concurrently, excess nuclei are expelled, enabling cyst‐to‐oocyte differentiation. The microfilament‐myosin II plays
Rui Xu, Menghao Pan, Zhi Zheng, Yaju Tang, Yutong Yan, Sihai Lu, Sha Peng, Baohua Ma   +7 more
wiley   +1 more source

Osteosarcoma in a patient with cranial fibrous dysplasia: a case report

Acta Clinica Croatica
Fibrous dysplasia is a benign fibro-osseous lesion which rarely undergoes malignant transformation, frequently after radiotherapy. Osteosarcoma is the most common malignancy arising in fibrous dysplasia.
Danko Müller, Naranđa Aljinović Ratković, Igor Blivajs, Dalibor Franćeski, Karolina Krstanac, Sven Seiwerth   +5 more
doaj   +1 more source