Results 1 to 10 of about 15,769 (198)

Effects of zoledronic acid therapy in fibrous dysplasia of bone: a single-center experience. [PDF]

Arch Endocrinol Metab, 2022
Objective: Fibrous dysplasia (FD) is a rare bone disorder that can involve any part of the skeleton, leading to bone pain, deformities, and fractures. Treatment with intravenous bisphosphonates has been used with variable results.
Valadares LP, de Araújo Ferreira BS, da Cunha BM, Moreira LA, Batista FGA, da Fonseca Hottz C, Magalhães GGR.   +6 more
europepmc   +2 more sources

RANKL Inhibition in Fibrous Dysplasia of Bone: A Preclinical Study in a Mouse Model of the Human Disease. [PDF]

J Bone Miner Res, 2019
Fibrous dysplasia of bone/McCune‐Albright syndrome (Polyostotic FD/MAS; OMIM#174800) is a crippling skeletal disease caused by gain‐of‐function mutations of Gsα.
Palmisano B, Spica E, Remoli C, Labella R, Di Filippo A, Donsante S, Bini F, Raimondo D, Marinozzi F, Boyde A, Robey P, Corsi A, Riminucci M.   +12 more
europepmc   +2 more sources

¹⁸ F-NaF PET/CT IMAGING IN FIBROUS DYSPLASIA OF BONE. [PDF]

J Bone Miner Res, 2019
Fibrous dysplasia (FD) is a mosaic skeletal disorder resulting in fractures, deformity, and functional impairment. Clinical evaluation has been limited by a lack of surrogate endpoints capable of quantitating disease activity.
Papadakis GZ, Manikis GC, Karantanas AH, Florenzano P, Bagci U, Marias K, Collins MT, Boyce AM.   +7 more
europepmc   +2 more sources

Age-Related Changes and Effects of Bisphosphonates on Bone Turnover and Disease Progression in Fibrous Dysplasia of Bone. [PDF]

J Bone Miner Res, 2019
Fibrous dysplasia (FD) is a mosaic disease in which bone is replaced with fibro‐osseous tissue. Lesions expand during childhood, reaching final burden by age 15 years.
Florenzano P, Pan KS, Brown SM, Paul SM, Kushner H, Guthrie LC, de Castro LF, Collins MT, Boyce AM.   +8 more
europepmc   +2 more sources

Mosaic Effects of Growth Hormone on Fibrous Dysplasia of Bone. [PDF]

N Engl J Med, 2018
Growth Hormone Effects in Mosaic Fibrous Dysplasia This case of mosaic fibrous dysplasia of bone shows hypersensitivity to growth hormone excess in affected bone, as compared with unaffected bone, ...
Roszko KL, Collins MT, Boyce AM.
europepmc   +2 more sources

Fibrous dysplasia of bone: craniofacial and dental implications. [PDF]

Oral Dis, 2017
Fibrous dysplasia (FD) is a rare bone disease caused by postzygotic somatic activating mutations in the GNAS gene, which lead to constitutive activation of adenylyl cyclase and elevated levels of cyclic AMP, which act on downstream signaling pathways and
Burke AB, Collins MT, Boyce AM.
europepmc   +2 more sources

Clinical and translational pharmacological aspects of the management of fibrous dysplasia of bone. [PDF]

Br J Clin Pharmacol, 2019
Fibrous dysplasia (FD) is a genetic, noninheritable rare bone disease caused by a postzygotic activating mutation of the α subunit of the stimulatory G‐protein causing increased abnormal bone formation leading to pain, deformity and fractures.
Rotman M, Hamdy NAT, Appelman-Dijkstra NM.   +2 more
europepmc   +2 more sources

Safety and Efficacy of Denosumab for Fibrous Dysplasia of Bone. [PDF]

N Engl J Med, 2023
de Castro LF, Michel Z, Pan K, Taylor J, Szymczuk V, Paravastu S, Saboury B, Papadakis GZ, Li X, Milligan K, Boyce B, Paul SM, Collins MT, Boyce AM.   +13 more
europepmc   +2 more sources

Fibrous Dysplasia of the Ethmoid Bone Diagnosed in a 10-Year-Old Patient [PDF]

Medicina
Fibrous dysplasia is an uncommon bone disorder affecting various parts of the skeleton, often affecting facial and cranial bones. In this case, a 10-year-old patient was diagnosed with fibrous dysplasia of the ethmoid sinus at an early age.
Zofia Resler, Monika Morawska-Kochman, Katarzyna Resler, Tomasz Zatoński   +3 more
doaj   +3 more sources

Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells [PDF]

Journal of Molecular Endocrinology, 2010
Activating mutations of the GNAS gene, which causes fibrous dysplasia of bone (FD), lead to remarkable changes in the properties of skeletal progenitors, and it is these changes that mediate the pathological effect of this gene on bone.
Mara Riminucci, Pamela Gehron Robey, Isabella Saggio, Paolo Bianco   +3 more
openalex   +2 more sources