Results 1 to 10 of about 245,543 (169)

Genetic basis for skeletal new bone formation [PDF]

Exploration of Musculoskeletal Diseases, 2023
Bone formation is a complex process that occurs throughout life, and is normally limited to the skeletal system. In bone formation, osteoprogenitor cells follow several developmental stages, including differentiation in osteoblasts, proliferation, matrix
Bruna Parreira, Ana Rita Couto, Luís Pinheiro, Jácome Bruges-Armas   +3 more
doaj   +1 more source

Madelung Deformity - Esthetic and Functional Outcomes from the Surgical Treatment with Distal Radial Dome Osteotomy and Vickers Ligament Section

Revista Brasileira de Ortopedia, 2022
Objective The present study aimed to evaluate esthetic and functional outcomes from the surgical treatment of Madelung deformity in children. MethodThis is a retrospective study of pediatric patients with Madelung deformity who were surgically treated ...
Marcos Carvalho, Pedro Sá Cardoso, Cristina Alves, Inês Balacó, Tah Pu Ling, Gabriel Matos   +5 more
doaj   +2 more sources

Deficiency of TMEM53 causes a previously unknown sclerosing bone disorder by dysregulation of BMP-SMAD signaling

Nature Communications, 2021
Sclerosing bone disorder (SBD) includes a broad spectrum of monogenic diseases characterised by increased bone density. Here, the authors describe a previously unknown SBD in four families caused by mutations in TMEM53 and demonstrate the role this ...
Long Guo, Aritoshi Iida, Gandham SriLakshmi Bhavani, Kalpana Gowrishankar, Zheng Wang, Jing-yi Xue, Juan Wang, Noriko Miyake, Naomichi Matsumoto, Takanori Hasegawa, Yusuke Iizuka, Masashi Matsuda, Tomoki Nakashima, Masaki Takechi, Sachiko Iseki, Shinsei Yambe, Gen Nishimura, Haruhiko Koseki, Chisa Shukunami, Katta M. Girisha, Shiro Ikegawa   +20 more
doaj   +1 more source

Early Life Stress (ELS) Effects on Fetal and Adult Bone Development

Children, 2023
Early life stress (ELS) refers to harmful environmental events (i.e., poor maternal health, metabolic restraint, childhood trauma) occurring during the prenatal and/or postnatal period, which may cause the ‘epigenetic corruption’ of cellular and ...
Xena Giada Pappalardo, Gianluca Testa, Rosalia Pellitteri, Paola Dell’Albani, Margherita Rodolico, Vito Pavone, Enrico Parano   +6 more
doaj   +1 more source

Lateral Mesoderm-Derived Mesenchymal Stem Cells With Robust Osteochondrogenic Potential and Hematopoiesis-Supporting Ability

Frontiers in Molecular Biosciences, 2022
Mesenchymal stem cells (MSCs) are among the most promising cell sources for the treatment of various diseases. Nonetheless, the therapeutic efficacy in clinical trials has been inconsistent due to the heterogeneity of MSCs, which may be partially ...
Yili Wei, Bin Wang, Lei Jia, Weijun Huang, Andy Peng Xiang, Andy Peng Xiang, Cong Fang, Xiaoyan Liang, Weiqiang Li, Weiqiang Li   +9 more
doaj   +1 more source

Engineering Musculoskeletal Grafts for Multi-Tissue Unit Repair: Lessons From Developmental Biology and Wound Healing

Frontiers in Physiology, 2021
In the musculoskeletal system, bone, tendon, and skeletal muscle integrate and act coordinately as a single multi-tissue unit to facilitate body movement.
Xu Zhang, Xu Zhang, Dan Wang, Dan Wang, Dan Wang, Dan Wang, King-Lun Kingston Mak, Rocky S. Tuan, Rocky S. Tuan, Dai Fei Elmer Ker, Dai Fei Elmer Ker, Dai Fei Elmer Ker, Dai Fei Elmer Ker   +12 more
doaj   +1 more source

Gaucher disease iPSC-derived osteoblasts have developmental and lysosomal defects that impair bone matrix deposition [PDF]

Human Molecular Genetics, 2018
Gaucher disease (GD) is caused by bi-allelic mutations in GBA1, the gene that encodes acid β-glucocerebrosidase (GCase). Individuals affected by GD have hematologic, visceral and bone abnormalities, and in severe cases there is also neurodegeneration. To shed light on the mechanisms by which mutant GBA1 causes bone disease, we examined the ability of ...
Leelamma M, Panicker, Manasa P, Srikanth, Thiago, Castro-Gomes, Diana, Miller, Norma W, Andrews, Ricardo A, Feldman   +5 more
openaire   +2 more sources

Lead exposure in adult males in urban Transvaal Province, South Africa during the apartheid era [PDF]

, 2013
Human exposure to lead is a substantial public health hazard worldwide and is particularly problematic in the Republic of South Africa given the country’s late cessation of leaded petrol. Lead exposure is associated with a number of serious health issues
A Mathee, A Mathee, A Mathee, A Mathee, A Mathee, A Navas-Acien, AC Todd, AM Motosue, B Nojilana, BP Lanphear, BS Glenn, Catherine A. Hess, CC Harper, Clive N. Trueman, D Byerlee, D Martin, DC Bellinger, DO Carpenter, DS Herman, E L’Abbe, E van Wijngaarden, F Monna, F van Gemert, H Hu, H Hu, H Hu, H Needleman, HL Needleman, HL Needleman, Holger Schutkowski, HW Mielke, I Baranowska, IA Bergdahl, J Heckman, Jaymie Meliker, JL Pirkle, JO Nriagu, JO Nriagu, JO Olowoyo, JO Olowoyo, JP Wright, K Bandeen-Roche, K Peltzer, K Peltzer, Ka Koller, KJA Thomas, KR Mahaffey, L Morrow, LE Wittmers, M Ezzati, M Faber, M Montgomery, Martin J. Smith, Matthew J. Cooper, MB Rabinowitz, MB Rabinowitz, MG Weisskopf, MR Dayal, NW White, OC Nweke, P Deveaux, P Muntner, PA Baghurst, PS Barry, PSI Barry, R Nevin, R Nevin, R Norman, R Smit, RA Goyer, RD Diab, RP Wedeen, RW Brown, SD Grosse, SR Grobler, WR Harlan, Y von Schirnding, Y von Schirnding, YER Von Schirnding, YER Von Schirnding, YW Cheng, ZR Kon   +81 more
core   +2 more sources

A new type of lordosis and vertebral body compression in Gilthead seabream, Sparus aurata Linnaeus, 1758: aetiology, anatomy and consequences for survival [PDF]

, 2013
A new type of vertebral malformation is described, consisting of deformed cartilaginous neural and haemal processes and the compression and fusion of vertebral bodies. The malformation is designated as haemal vertebral compression and fusion (haemal VCF).
Georgiou, AN, Koumoundouros, G, Loizides, M, Somarakis, S, Witten, Paul   +4 more
core   +2 more sources

Mapping the immune microenvironment for mandibular alveolar bone homeostasis at single-cell resolution

Bone Research, 2021
Alveolar bone is the thickened ridge of jaw bone that supports teeth. It is subject to constant occlusal force and pathogens invasion, and is therefore under active bone remodeling and immunomodulation. Alveolar bone holds a distinct niche from long bone
Weimin Lin, Qiwen Li, Danting Zhang, Xiaohan Zhang, Xingying Qi, Qian Wang, Yaqian Chen, Caojie Liu, Hanwen Li, Shiwen Zhang, Yuan Wang, Bin Shao, Li Zhang, Quan Yuan   +13 more
doaj   +1 more source