Results 21 to 30 of about 245,662 (288)

MicroRNAs in B cell development and malignancy [PDF]

, 2012
MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and ...
Fernando, Thilini R., Rao, Dinesh S., Rodriguez-Malave, Norma I.   +2 more
core   +4 more sources

Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells [PDF]

, 2016
Innate lymphoid cells (ILCs) patrol environmental interfaces to defend against infection and protect barrier integrity. Using a genetic tuning model, we demonstrate that the signal-dependent transcription factor (TF) STAT5 is critical for accumulation of
Villarino, Alejandro V^, Sciumè, Giuseppe^, Davis, Fred P, Iwata, Shigeru, Zitti, Beatrice, Robinson, Gertraud W, Hennighausen, Lothar, Kanno, Yuka, O'Shea, John J, ^Co-Firs, T.   +9 more
core   +1 more source

Appraisement of Some Heavy Metals in Kuru Dam, Jos South L.G.A, Plateau State, Nigeria

Journal of Applied Sciences and Environmental Management, 2023
The objective of this study was to assess the concentrations of selected heavy metals at Kuru Dam. The result obtained shows that Fe ranged from 0.05- 0.55ppm, As 0.13-0.18ppm, Cu 0.06-0.36ppm, Pb 0.08 -0.46, Cd 0.01-0.02ppm, while Zn 0.01-0.01ppm.
E. Oiganji, D. C. Stella, S. S. Kahya, A. Ahmed   +3 more
doaj   +1 more source

Spina bifida-predisposing heterozygous mutations in Planar Cell Polarity genes and Zic2 reduce bone mass in young mice [PDF]

, 2018
Fractures are a common comorbidity in children with the neural tube defect (NTD) spina bifida. Mutations in the Wnt/planar cell polarity (PCP) pathway contribute to NTDs in humans and mice, but whether this pathway independently determines bone mass is ...
A Kamalakar, A Trinh, AJ Copp, AJ Copp, AS Findlay, B Wang, BA Alman, C Cooper, C Hartmann, CF Davey, CH Chen, D Karasik, D Szklarczyk, DG Winkler, DJ Epstein, DM Juriloff, E Canalis, E Nikolopoulou, EM Curtis, GH Li, GL Galea, GL Galea, GL Galea, GL Galea, H Marreiros, H Yin, HF Zheng, IR Orriss, IR Orriss, JK Morris, JN Murdoch, K Estrada, KC Keller, KS Joeng, L D’Andrea, LJ Martin, LL Yates, LL Yates, M Akbar, M Kalogeropoulos, ME Ross, MJ Anderson, MJ Harris, MJ Harris, MR Dohn, NC Nowlan, P Andre, P Elms, P Ybot-Gonzalez, P Ybot-Gonzalez, R Klootwijk, R Xu, S Babayeva, S Li, S Maere, SA Brown, SE Taylor, SJ Conway, T Dodge, T Yang, UM Ayturk, V Martinelli, W Yang, Y Erdem, Y Koyabu, Y Lei, Z Kibar   +66 more
core   +3 more sources

Developmental and bone development indexes of medaka fish at 11 and 16 days of age

Vietnam Journal of Science, Technology and Engineering, 2018
The teleost fish medaka (Oryzias latipes) is currently used by laboratories worldwide as a model for many human diseases, including bone diseases. Our research group focuses on a medaka model for osteoporosis.
Thi Kieu Oanh Pham, Van Cuong Pham, Thi Thuy Lai, Thanh Thuy To   +3 more
doaj   +1 more source

Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]

, 2016
Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core   +1 more source

Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

eLife, 2019
Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH receptor Smoothened (SMO), in chondrocyte or osteoblasts does not cause ...
Qi Deng, Ping Li, Manju Che, Jiajia Liu, Soma Biswas, Gang Ma, Lin He, Zhanying Wei, Zhenlin Zhang, Yingzi Yang, Huijuan Liu, Baojie Li   +11 more
doaj   +1 more source

Developmental Bone Diseases in our Clinic

Orthopedics & Traumatology, 1975
Thirty-two patients with the developmental bone disease were registered in the department of orthopedic surgery, Tottori university school of medicine, for the past three years.The authors made a description of the clinical features and radiologic findings of the following patients.1) Chondrodysplasia punctata (an one-year-old young girl)2 ...
M. Kamihira, K. Ikemoto, O. Sumisaka
openaire   +2 more sources

Caracterización de pacientes con enfermedades genéticas del esqueleto en un centro colombiano de remisión

Biomédica: revista del Instituto Nacional de Salud, 2017
Introducción. La prevalencia de talla baja en Colombia es de 10 %, aproximadamente. En el 2009, la International Skeletal Dysplasia Society incluyó 456 condiciones clínicas en su clasificación, con base en criterios bioquímicos, radiológicos y ...
Harvy Mauricio Velasco, Lina Patricia Buelvas   +1 more
doaj   +1 more source

A rare case of pancytopenia

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023
Pancytopenia is a reduction in all the three peripheral blood cell lineages and presents as anemia, leukopenia, and thrombocytopenia. Aplastic anemia is pancytopenia with bone marrow hypocellularity.
Manaswini Edara, Varsha Bhatt, Shubhangi A Kanitkar, Aditi Patel   +3 more
doaj   +1 more source