Results 41 to 50 of about 4,253,135 (331)

Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

eLife, 2019
Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH receptor Smoothened (SMO), in chondrocyte or osteoblasts does not cause ...
Qi Deng, Ping Li, Manju Che, Jiajia Liu, Soma Biswas, Gang Ma, Lin He, Zhanying Wei, Zhenlin Zhang, Yingzi Yang, Huijuan Liu, Baojie Li   +11 more
doaj   +1 more source

Appraisement of Some Heavy Metals in Kuru Dam, Jos South L.G.A, Plateau State, Nigeria

Journal of Applied Sciences and Environmental Management, 2023
The objective of this study was to assess the concentrations of selected heavy metals at Kuru Dam. The result obtained shows that Fe ranged from 0.05- 0.55ppm, As 0.13-0.18ppm, Cu 0.06-0.36ppm, Pb 0.08 -0.46, Cd 0.01-0.02ppm, while Zn 0.01-0.01ppm.
E. Oiganji, D. C. Stella, S. S. Kahya, A. Ahmed   +3 more
doaj   +1 more source

Osteocytic HIF-1α Pathway Manipulates Bone Micro-structure and Remodeling via Regulating Osteocyte Terminal Differentiation

Frontiers in Cell and Developmental Biology, 2022
The activation of hypoxia-inducible factor 1α (HIF-1α) signaling has promising implications for the treatment of bone diseases such as osteoporosis and skeletal fractures.
Kaizhe Chen, J. Zhao, Minglong Qiu, Lian-Fang Zhang, Kai Yang, Lei-Lei Chang, P. Jia, Jin Qi, L. Deng, Chang-Wei Li   +9 more
semanticscholar   +1 more source

Quantitative Ultrasound of Cortical Bone in the Femoral Neck Predicts Femur Strength: Results of a Pilot Study [PDF]

, 2013
Article first published online: 15 JAN 2013 Pour consulter la version éditeur DOI: 10.1002/jbmr.1742A significant risk of femoral neck (FN) fracture exists for men and women with an areal bone mineral density (aBMD) higher than the osteoporotic range ...
GRONDIN, Julien, ENGELKE, Klaus, Reinhard Barkmann, GRIMAL, Quentin, Quentin Grimal, Sandra Guérard, Glüer, Claus-C., Julien Grondin, GUÉRARD, Sandra, Klaus Engelke, GLÜER, Claus-C, BARKMANN, Reinhard, Claus‐C Glüer, Pascal Laugier, LAUGIER, Pascal   +14 more
core   +1 more source

Caracterización de pacientes con enfermedades genéticas del esqueleto en un centro colombiano de remisión

Biomédica: revista del Instituto Nacional de Salud, 2017
Introducción. La prevalencia de talla baja en Colombia es de 10 %, aproximadamente. En el 2009, la International Skeletal Dysplasia Society incluyó 456 condiciones clínicas en su clasificación, con base en criterios bioquímicos, radiológicos y ...
Harvy Mauricio Velasco, Lina Patricia Buelvas   +1 more
doaj   +1 more source

Cilia/Ift protein and motor-related bone diseases and mouse models

Frontiers in Bioscience, 2015
Primary cilia are essential cellular organelles projecting from the cell surface to sense and transduce developmental signaling. They are tiny but have complicated structures containing microtubule (MT)-based internal structures (the axoneme) and mother ...
Xue Yuan, Shuying Yang
semanticscholar   +1 more source

Recent Advances of Osterix Transcription Factor in Osteoblast Differentiation and Bone Formation

Frontiers in Cell and Developmental Biology, 2020
With increasing life expectations, more and more patients suffer from fractures either induced by intensive sports or other bone-related diseases. The balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption is the basis
Qian Liu, Mao Li, Shiyi Wang, Zhousheng Xiao, Yuan-yuan Xiong, Guangwei Wang   +5 more
semanticscholar   +1 more source

Matrix vesicles from dental follicle cells improve alveolar bone regeneration via activation of the PLC/PKC/MAPK pathway

Stem cell research & therapeutics, 2022
The regeneration of bone loss that occurs after periodontal diseases is a significant challenge in clinical dentistry. Extracellular vesicles (EVs)-based cell-free regenerative therapies represent a promising alternative for traditional treatments ...
Genzheng Yi, Siyuan Zhang, Yue Ma, Xueting Yang, F. Huo, Yan Chen, Bo Yang, W. Tian   +7 more
semanticscholar   +1 more source

A rare case of pancytopenia

Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2023
Pancytopenia is a reduction in all the three peripheral blood cell lineages and presents as anemia, leukopenia, and thrombocytopenia. Aplastic anemia is pancytopenia with bone marrow hypocellularity.
Manaswini Edara, Varsha Bhatt, Shubhangi A Kanitkar, Aditi Patel   +3 more
doaj   +1 more source

Advance in the application of organoids in bone diseases

Frontiers in Cell and Developmental Biology
Bone diseases such as osteoporosis and osteoarthritis have become important human health problems, requiring a deeper understanding of the pathogenesis of related diseases and the development of more effective treatments.
Yajie Kong, Yu-Jia Yang, Yu Hou, Yu-Zhong Wang, Wenjing Li, Yongzhou Song   +5 more
semanticscholar   +1 more source