Results 51 to 60 of about 4,253,135 (331)

Bone Marrow Adipocyte Developmental Origin and Biology

Current Osteoporosis Reports, 2018
Purpose of ReviewThis review explores how the relationships between bone marrow adipose tissue (BMAT) adipogenesis with advancing age, obesity, and/or bone diseases (osteopenia or osteoporosis) contribute to mechanisms underlying musculoskeletal ...
J. Bukowska, Trivia P Frazier, Stanley Smith, Theodore A. Brown, R. Bender, Michelle McCarthy, Xi-Ying Wu, B. Bunnell, J. Gimble   +8 more
semanticscholar   +1 more source

Cathepsin K: The Action in and Beyond Bone

Frontiers in Cell and Developmental Biology, 2020
Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases family, of which main function is to mediate bone resorption. Currently, CatK is among the most attractive targets for anti-osteoporosis drug development.
Rongchen Dai, Zeting Wu, H. Chu, Jun Lu, Aiping Lyu, Jin Liu, Ge Zhang   +6 more
semanticscholar   +1 more source

A Review Into the Insights of the Role of Endothelial Progenitor Cells on Bone Biology

Frontiers in Cell and Developmental Biology, 2022
In addition to its important transport functions, the skeletal system is involved in complex biological activities for the regulation of blood vessels.
Henglei Shi, Zhenchen Zhao, Wei-Dong Jiang, P. Zhu, Nuo Zhou, Xuan-Ping Huang   +5 more
semanticscholar   +1 more source

Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineering [PDF]

, 2010
Mesenchymal stem/stromal cells (MSC) are typically used to generate bone tissue by a process resembling intramembranous ossification, i.e., by direct osteoblastic differentiation.
Schaeren, Stefan, Tonnarelli, Beatrice, Zeller, Rolf, Scotti, Celeste, Papadimitropoulos, Adam, Schauerte, Alexandra, Martin, Ivan, Scherberich, Arnaud, Lopez-Rios, Javier, Barbero, Andrea   +9 more
core   +1 more source

Ferroptosis and Its Potential Role in Metabolic Diseases: A Curse or Revitalization?

Frontiers in Cell and Developmental Biology, 2021
Ferroptosis is classified as an iron-dependent form of regulated cell death (RCD) attributed to the accumulation of lipid hydroperoxides and redox imbalance.
Jia-Yue Duan, Xiao Lin, Feng Xu, S. Shan, Bei Guo, Fu-Xing-Zi Li, Yi Wang, Ming-Hui Zheng, Qiu-Shuang Xu, Li-Min Lei, Wenlu Ouyang, Yunying Wu, Kexuan Tang, Ling-Qing Yuan   +13 more
semanticscholar   +1 more source

Epigenetic regulation during fetal femur development: DNA methylation matters [PDF]

, 2013
Epigenetic modifications are heritable changes in gene expression without changes in DNA sequence. DNA methylation has been implicated in the control of several cellular processes including differentiation, gene regulation, development, genomic ...
Oreffo Richard O. C., Oreffo, Richard O. C., Antonio Gonzalez, González Martínez-Pedrayo, Antonio, Imagawa, K., Richard O C Oreffo, de Andrés María C., Gonzalez, A., Roach Helmtrud I., Wilson, David I., Kingham, Emmajayne, Oreffo, R.O., Kingham Emmajayne, Helmtrud I Roach, Oreffo, Richard O C, Gomez-Reino, J.J., Emmajayne Kingham, Kei Imagawa, María C de Andrés, Wilson, D.I., Roach, Helmtrud I, Wilson David I., de Andrés, María C., Imagawa, Kei, Roach, Helmtrud I., De Andrés González, Mª Carmen, Imagawa Kei, Wilson, David I, Neves, Nuno M., David I Wilson, Gonzalez, Antonio, Roach, H.I., Kingham, E., Gonzalez Antonio, de Andrés, M.C.   +34 more
core   +1 more source

From mesenchymal niches to engineered in vitro model systems: Exploring and exploiting biomechanical regulation of vertebrate hedgehog signalling

Materials Today Bio, 2022
Tissue patterning is the result of complex interactions between transcriptional programs and various mechanical cues that modulate cell behaviour and drive morphogenesis.
Fatmah I. Ghuloum, Colin A. Johnson, Natalia A. Riobo-Del Galdo, Mahetab H. Amer   +3 more
doaj   +1 more source

Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases

Experimental and Molecular Medicine
Osteoclasts are the principal cells that efficiently resorb bone. Numerous studies have attempted to reveal the molecular pathways leading to the differentiation and activation of osteoclasts to improve the treatment and prevention of osteoporosis and ...
N. Takegahara, Hyunsook Kim, Yongwon Choi   +2 more
semanticscholar   +1 more source

Age and Sexual Maturity Estimation of Stranded Striped Dolphins, Stenella coeruleoalba, Infected with Brucella ceti

Oceans, 2022
Age parameters in cetaceans allow examining conservation and studying individuals with growth affection. The age and sexual maturity of 51 stranded Stenella coeruleoalba striped dolphins from the Eastern Tropical Pacific (ETP) of Costa Rica, most ...
Karol Roca-Monge, Rocío González-Barrientos, Marcela Suárez-Esquivel, José David Palacios-Alfaro, Laura Castro-Ramírez, Mauricio Jiménez-Soto, Minor Cordero-Chavarría, Daniel García-Párraga, Ashley Barratclough, Edgardo Moreno, Gabriela Hernández-Mora   +10 more
doaj   +1 more source

Regulation of Osteoclastogenesis and Bone Resorption by miRNAs

Frontiers in Cell and Developmental Biology, 2021
Osteoclasts are specialized bone-resorbing cells that contribute to physiological bone development and remodeling in bone metabolism throughout life.
Kazuki Inoue, Courtney Ng, Yuhan Xia, Baohong Zhao   +3 more
semanticscholar   +1 more source