Results 61 to 70 of about 4,253,135 (331)

IGF2BP3 recognizes m6A to regulate histone-to-protamine replacement during mouse sperm development

The EMBO Journal
Post-meiotic development of spermatids is under the control of a sophisticated RNA metabolic network, wherein the N6-methyladenosine (m6A) modification of mRNA, and proteins that bind to it, exert crucial functions in regulating sperm development from ...
Dazhuang Wang, Zhenyi Huang, Yichun Zhou, Peiyan Chen, Gang Chang, Liwei Ke, Congying Jing, Haojie Yang, Jiexiang Zhao, Shaofang Ren, Yi Zheng, Yuhan Chen, Yunfan Xiang, Jun Liu, Mei Wang   +14 more
doaj   +1 more source

The Progress of CRISPR/Cas9-Mediated Gene Editing in Generating Mouse/Zebrafish Models of Human Skeletal Diseases

Computational and Structural Biotechnology Journal, 2019
Genetic factors play a substantial role in the etiology of skeletal diseases, which involve 1) defects in skeletal development, including intramembranous ossification and endochondral ossification; 2) defects in skeletal metabolism, including late bone ...
Nan Wu, Bowen Liu, Huakang Du, Sen Zhao, Yaqi Li, Xi Cheng, Shengru Wang, Jiachen Lin, Junde Zhou, Guixing Qiu, Zhihong Wu, Jianguo Zhang   +11 more
doaj   +1 more source

Research progress on the role of transforming growth factor-β in tooth and craniofacial bone development and diseases

口腔疾病防治, 2022
Dental and craniofacial bone development is a highly coordinated process that is tightly controlled by genetics and influenced by complex environments.
CAI Lang, XIE Jing, ZHOU Xuedong
doaj   +1 more source

Obesity and Bone Health: A Complex Link

Frontiers in Cell and Developmental Biology, 2020
So far, the connections between obesity and skeleton have been extensively explored, but the results are inconsistent. Obesity is thought to affect bone health through a variety of mechanisms, including body weight, fat volume, bone formation/resorption,
Jing Hou, Chen He, Wenzhen He, Mi Yang, Xianghang Luo, Changjun Li   +5 more
semanticscholar   +1 more source

Comprehensive bioinformatics analysis of susceptibility genes for developmental dysplasia of the hip.

Intractable & Rare Diseases Research, 2022
Developmental dysplasia of the hip (DDH) is a multifactorial disease, which occurs under environmental and genetic influence. The etiopathogenesis of DDH has not been fully explained.
Wei Yang, Guiyang Jin, Keying Qian, Chao Zhang, Wei Zhi, Dan Yang, Yanqin Lu, Jin-Xiang Han   +7 more
semanticscholar   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source

A monoallelic variant in CCN2 causes an autosomal dominant spondyloepimetaphyseal dysplasia with low bone mass

Bone Research
Cellular communication network factor 2 (CCN2) is a secreted extracellular matrix-associated protein, and its aberrantly increased expression has been implicated in a diversity of diseases involving pathological processes of fibrosis, chronic ...
Shanshan Li, Rui Shao, Shufa Li, Jiao Zhao, Qi Deng, Ping Li, Zhanying Wei, Shuqin Xu, Lin Chen, Baojie Li, Weiguo Zou, Zhenlin Zhang   +11 more
doaj   +1 more source

Alliances of the gut and bone axis.

Seminars in Cell and Developmental Biology, 2021
Gut hormones secreted from enteroendocrine cells following nutrient ingestion modulate metabolic processes including glucose homeostasis and food intake, and several of these gut hormones are involved in the regulation of the energy demanding process of ...
Morten S. Hansen, M. Frost
semanticscholar   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Comparison studies identify mesenchymal stromal cells with potent regenerative activity in osteoarthritis treatment

npj Regenerative Medicine
Osteoarthritis affects 15% of people over 65 years of age. It is characterized by articular cartilage degradation and inflammation, leading to joint pain and disability.
Hongshang Chu, Shaoyang Zhang, Zhenlin Zhang, Hua Yue, Huijuan Liu, Baojie Li, Feng Yin   +6 more
doaj   +1 more source