Results 41 to 50 of about 254,882 (308)

Fibrous scaffolds for bone tissue engineering

, 2020
More than 1 million orthopedic procedures are performed in the U.S. each year, for reconstructive surgery, trauma, or abnormal skeletal defects. Bone grafts are typically used in these procedures.
Apurva Limaye, Treena Livingston Arinzeh, Moy, Jennifer, Limaye, Apurva, Jennifer Moy, Arinzeh, Treena Livingston   +5 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

European Society of Biomechanics SM Perren Award 2010 : an adaptation mechanism for fibrous tissue to sustained shortening

, 2010
The mechanism by which fibrous tissues adapt upon alterations in their mechanical environment remains unresolved. Here, we determine that periosteum in chick embryos resides in an identical mechanical state, irrespective of the developmental stage.
Donkelaar, van, C.C., Ito, K Keita, Foolen, J., Foolen, J.; id_orcid, Donkelaar, CC René van, Soekhradj - Soechit, R.S., Sarita Soekhradj-Soechit, Keita Ito, Foolen, J Jasper, Corrinus C. van Donkelaar, Jasper Foolen, Ito, K., Soekhradj - Soechit, RS Sarita   +12 more
core   +1 more source

Expression of RANKL in breast cancer tissue in patients with fibrous dysplasia/McCune-Albright syndrome

, 2023
BACKGROUND: In fibrous dysplasia/McCune-Albright syndrome (FD/MAS), mosaic mutations in the GNAS gene lead to locally abnormal bone turnover. Additionally, patients with FD/MAS, particularly with thoracic lesions, have an increased risk for breast cancer.
Meier, M.E., Hagelstein-Rotman, M., Bravenboer, N., Appelman-Dijkstra, N.M., Geels, R.E.S., Bravenboer, N, Hagelstein-Rotman, M, Geels, R E S, Meier, M E, Majoor, B C J, Appelman-Dijkstra, N M, Majoor, B.C.J.   +11 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A Large Vulvar Acrochordon in an 80‐Year‐Old Woman: A Neglected Hanging Lesion

Clinical Case Reports
Giant acrochordons are extremely rare in sizes bigger than 5 cm and even more extreme in postmenopausal women. Treatment of vulvar diseases can present significant challenges, particularly when dealing with older patients with co‐morbidities ...
Vaia Sarli, Maria‐Gesthimani Chousmekeridou, Ioannis Arkoulis, Theodoros Karampitsakos, Chryssi Christodoulaki, Peter Drakakis, Sofoklis Stavros, Periklis Panagopoulos, Anastasios Potiris   +8 more
doaj   +1 more source

Skeletal muscle ultrasound: correlation between fibrous tissue and echo intensity.

, 2009
Contains fulltext : 81544.pdf (Publisher’s version ) (Open Access)In this study, we examined the correlation between muscle ultrasound and muscle structure.
Pillen, S., Engelen, B.G.M. van, Tak, R.O., Hoogerbrugge, P.M., Laak, J.A.W.M. van der, Zwarts, M.J., Arts, I.M.P., Verrijp, K., Lammens, M.M.Y., Verrips, A.   +9 more
core   +1 more source

Leveling Up Hydrogels:Hybrid Systems in Tissue Engineering [PDF]

, 2020
Hydrogels can mimic several features of the cell native microenvironment and have been widely used as synthetic extracellular matrices (ECMs) in tissue engineering and regenerative medicine (TERM).
Moroni, Lorenzo; id_orcid, Moroni, Lorenzo, Barrias, Cristina C., Neves, Sara C., Granja, Pedro L.   +4 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source