Results 161 to 170 of about 5,407 (192)

Characterization of Ficolins as Novel Elastin-Binding Proteins and Molecular Cloning of Human Ficolin-1

Journal of Biochemistry, 1996
A novel elastin-binding protein, EBP-37, was recently identified and purified from human plasma. Its partial amino acid sequences showed significant homology to porcine ficolins, which were originally purified from porcine uterus membranes as multimeric proteins with fibrinogen- and collagen-like domains.
S, Harumiya, K, Takeda, T, Sugiura, Y, Fukumoto, H, Tachikawa, K, Miyazono, D, Fujimoto, H, Ichijo   +7 more
openaire   +2 more sources

Binding of Ficolin-1 to the long pentraxin PTX3: Interacting domain and function on apoptotic cells

Molecular Immunology, 2011
Introduction: Proteins of the innate immune system can act as natural inhibitors of invading pathogens and autoimmunity. Ficolin-1 and the long pentraxin 3 (PTX3) are soluble pattern recognition molecules that possess such function in inflammation and innate immunity.
Y.J. Ma Ma, A. Doni, L. Romani, M.O. Skjoedt, A. Mantovani, P. Garred   +5 more
openaire   +3 more sources

The Bidirectional Orchestrator: Ficolin‐1's Pivotal Role in Innate Immunity and Disease

Immunology
ABSTRACT Ficolin‐1 (FCN1, M‐FCN), the key pattern recognition molecule of the innate immune system, possesses a collagen‐like domain and a fibrinogen‐like domain, exhibiting bidirectional immunomodulatory functions that influence immune homeostasis and disease progression.
Cao Yu, Li Lei, Ji Zhenhua, Tian Linghan, Li Jia, Huang Youguang, Zhu Lei   +6 more
openaire   +2 more sources

Abstract 4143606: Ficolin-1 Genetic Polymorphisms in Chronic Chagasic Cardiomyopathy

Circulation
Background: Chagas disease (CD) is an infectious disease caused by the protozoa Trypanosoma cruzi , affecting around 6-7 million people in Latin America. Although most infected individuals remain asymptomatic throughout their lives, annually 2-5% of them progress to chronic chagasic cardiomyopathy (CCC),
Pamela Fontana, Fabiana Andrade, Karita Lidani, Helena Placido, Sandra Catarino, Iara de Messias-Reason   +5 more
openaire   +1 more source

Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP

Journal of Leukocyte Biology, 2008
Abstract Ficolin-1 is present in gelatinase granules and also in a previously unknown highly mobilizable subset of granules; once released, ficolin-1 binds to the neutrophil surface. Ficolins are soluble molecules that bind carbohydrate present on the surface of microorganisms and function as recognition molecules in the ...
Rørvig, Sara, Honoré, Christian Le Fèvre, Larsson, Lars-Inge, Ohlsson, Sophie, Pedersen, Corinna C., Jacobsen, Lars C., Cowland, Jack B., Garred, Peter, Borregaard, Niels   +8 more
openaire   +3 more sources

The pattern recognition molecule ficolin-1 exhibits differential binding to lymphocyte subsets, providing a novel link between innate and adaptive immunity

Molecular Immunology, 2014
Ficolin-1 is a soluble pattern recognition molecule synthesized by myeloid cells and capable of activating the lectin pathway of complement on the surface of pathogens. It is tethered to the membranes of monocytes and granulocytes; however, the biological significance of cell-associated ficolin-1 is unknown.
Genster, Ninette, Ma, Ying Jie, Munthe-Fog, Lea, Garred, Peter   +3 more
openaire   +4 more sources

Association of Ficolin 1 promoter polymorphisms with clinical leprosy

Molecular Immunology, 2010
A.B.W. Boldt, M.I.N. Sanchez, E.R.S. Stahlke, I.J.T. Messias-Reason   +3 more
openaire   +1 more source

Expression and synthesis of Ficolin-1 in monocytes, macrophages and dendritic cells

Molecular Immunology, 2007
Christian Honoré, Tina Hummelshoj, Bjarke Endel Hansen, Hans Ole Madsen, Peter Garred   +4 more
openaire   +1 more source

Ficolin-1 expression reflects FCN1 genotypic variation

Molecular Immunology, 2011
L.M.F. Munthe-Fog, M.E.M. Møller, C.F.H. Honore, T.H. Hummelshoj, P.G. Garred   +4 more
openaire   +1 more source

Ficolin-1 binds to sialic acid on the surface of peripheral blood monocytes

Molecular Immunology, 2008
Christian Honoré, Tina Hummelshoj, Peter Garred   +2 more
openaire   +1 more source