Results 41 to 50 of about 1,210,830 (238)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Who’s going the distance here? Fictive motion in (German) sign language
Cognitive LinguisticsFrame-relative fictive motion describes a linguistic phenomenon whereby the motion of an entity is communicated via the – fictive – motion of stationary background objects.
Loos Cornelia, Napoli Donna Jo
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
, 2006 : This paper focuses on a specific subtype of motion, known in the field as fictive motion. In our analysis, we have discovered that the MOTION metaphor, in combination with metonymy and image-schemas, underlies the semantic configuration of fictive ...
Jiménez Martínez-Losa, Noelia
core +1 more source
Orientation path in Vietnamese: a cognitive-linguistic description
Cogent Arts & HumanitiesOver the past few decades, motion in general, and fictive motion in particular, have been central topics in cognitive linguistics. Numerous cognitive linguists have explored these topics across many languages. Their research has provided us with profound
Duong Huu Bien
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Cross-corpora analysis of spatial language: The case of fictive motion [PDF]
, 2019 The way people describe where things are is one of the central questions of spatial information theory and has been the subject of considerable research.
Egorova E +3 more
core +2 more sources
زبان کاوی کاربردی, 2023 This study aims to comparatively investigate the semantic frames of motion directional verbs in Persian and English within the framework of the frame semantics theory (Fillmore 1977; 1982; 1985).
Tahereh Samenian
doaj
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source