Results 51 to 60 of about 1,210,830 (238)

On SENSORY PATH and other asymmetries in the encoding of vision and hearing: the case of English

open access: yesCogniTextes
The present article examines directional encoding of visual and auditory perception in English, i.e., expressions where the relationship between the experiencer and the perceived phenomenon is conveyed as a directional one (e.g., Professor McGonagall ...
Yana Aquilina
doaj   +1 more source

The ridge went north : Did the observer go as well? Corpus-driven investigation of fictive motion [PDF]

open access: yes, 2016
Fictive motion (“The ridge went north”) can refer to both dynamic (observer is moving) and static (observer is visually scanning) scenes. Using a corpus of alpine narratives, we extract fictive motion constructions and compare those representing static ...
Egorova, Ekaterina   +6 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Fictive motion and the visual world [PDF]

open access: yes, 2016
© 2016 John Benjamins Publishing Company. This is the accepted manuscript of a chapter published in Knoeferle, P., Pyykkönen-Klauck, P., & Crocker, M. W. (Eds.). (2016). Visually Situated Language Comprehension. Advances in Consciousness Research.
Stephanie Huette   +3 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

open access: yesMolecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna   +8 more
wiley   +1 more source

L'italien [ANDARE A + infinitif ]: fondements des valeurs discursives

open access: yesCorela
This article argues against a clear-cut distinction between a compositional and a non-compositional version of the Italian [andare a + infinitive] construction, the latter here qualified as semi-compositional. Grammaticalization and semantic bleaching of
Christopher Desurmont
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

open access: yesMolecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński   +12 more
wiley   +1 more source

Fictive Motion: Construction or Construal?

open access: yesAnnual Meeting of the Berkeley Linguistics Society, 2006
N ...
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

open access: yesFEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph   +7 more
wiley   +1 more source

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