Results 61 to 70 of about 533,902 (337)

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

A novel robust method for estimating the covariance matrix of financial returns with applications to risk management

open access: yesFinancial Innovation
This study introduces the dynamic Gerber model (DGC) and evaluates its performance in the prediction of Value at Risk (VaR) and Expected Shortfall (ES) compared to alternative parametric, non-parametric and semi-parametric methods for estimating the ...
Arturo Leccadito   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Demographic consequences of translocation of overabundant Canada geese breeding in urban areas

open access: yesWildlife Society Bulletin, 2017
Translocation is a common tool for managing nuisance Canada geese (Branta canadensis) in urban areas across North America. However, no previous research has assessed how translocation affects survival and philopatry at donor and release sites.
D. T. Tyler Flockhart, Jared B. Clarke
doaj   +1 more source

Au temps où la tradition était un dynamisme. Le témoignage d’Irénée de Lyon

open access: yesCahiers d'Études du Religieux- Recherches Interdisciplinaires, 2023
The purpose of this study is to retrace the main lines of the first theology of tradition elaborated by Irenaeus of Lyon. For him, traditio refers to an action : “the act of transmitting”, “the process by which one transmits” rather than the content ...
Marie-Laure Chaieb
doaj   +1 more source

Multi-fidelity Bayesian neural networks: Algorithms and applications [PDF]

open access: green, 2021
Xuhui Meng   +2 more
openalex   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Communication without communication [PDF]

open access: yesZbornik Radova Filozofskog Fakulteta u Prištini, 2017
This paper analyses the necessary conditions for successful communication. It is well known that post-modernity, described as an era of control, produces only decentralized, imploded subjectivities, who are neither able to question their own being nor to
Bratina Boris R., Knëževič Višnja D.
doaj   +1 more source

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