Global healthcare has long benefited from traditional medical systems. Hassan District, which is geospatially located in the Western Ghats, has a long history of using traditional medicines owing to the region’s rich plant diversity.
Kushavara Venkatesh Amara +2 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
A Two-Step Machine Learning Approach for Crop Disease Detection Using GAN and UAV Technology
Automated plant diagnosis is a technology that promises large increases in cost-efficiency for agriculture. However, multiple problems reduce the effectiveness of drones, including the inverse relationship between resolution and speed and the lack of ...
Aaditya Prasad +3 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Fidelity decay of the two-level bosonic embedded ensembles of random matrices [PDF]
We study the fidelity decay of the $k$-body embedded ensembles of random matrices for bosons distributed over two single-particle states. Fidelity is defined in terms of a reference Hamiltonian, which is a purely diagonal matrix consisting of a fixed one-body term and includes the diagonal of the perturbing $k$-body embedded ensemble matrix, and the ...
Luis Benet +6 more
openaire +2 more sources
Evaluation of a digital textbook program in terms of implementation fidelity
The purpose of this study is to investigate the effect of a digital textbook program in terms of program implementation fidelity. The outcome variable of the program was defined as changes in pre- and post-scores of student competencies composed of self ...
Hyesook Kim, Anna Shin, Bokyung Kye
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
RNA‐related functions of BRCA2 in transcription, replication, and genome stability
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda +2 more
wiley +1 more source
Evaluating and Preserving High-level Fidelity in Super-Resolution
Recent image Super-Resolution (SR) models are achieving impressive effects in reconstructing details and delivering visually pleasant outputs. However, the overpowering generative ability can sometimes hallucinate and thus change the image content despite gaining high visual quality. This type of high-level change can be easily identified by humans yet
Josep M. Rocafort +3 more
openaire +2 more sources
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source

