Results 71 to 80 of about 254,435 (267)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Methods for measuring implementation fidelity to the transitional care model

Trials
Background Fidelity is defined as the extent to which an intervention is delivered as intended. Without a clear understanding of fidelity to an intervention, variability in implementation may be confounded with observed outcomes, making valid conclusions
Monica L. Ahrens, Alexandra L. Hanlon, Karen B. Hirschman, Molly McHugh, Onome H. Osokpo, Kathleen McCauley, Elizabeth C. Shaid, Mark V. Pauly, Mark Toles, Mary D. Naylor   +9 more
doaj   +1 more source

Evolutionary de-homogenization using a generative model for optimizing solid-porous infill structures considering the stress concentration issue

Materials & Design
Designing porous infill structures is challenging due to complex geometries, where accurate boundary representation and localized stress control are critical. Traditional methods like topology optimization rely on voxel-based models, leading to geometric
Shuzhi Xu, Hiroki Kawabe, Kentaro Yaji
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Exploring indigenous wisdom: Ethnobotanical documentation and conservation of medicinal plants in Goba District, Southwest Ethiopia

Scientific African
Understanding the community's knowledge and reliance on plant based traditional medicine is crucial for creating effective, sustainable conservation strategies to protect and preserve these valuable plant resources.
Ginjo Gitima, Ashenafi Gebre, Yericho Berhanu, Tamirat Wato   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Relacionamento com clientes do setor farmacêutico em Vitória-ES: uma análise dos impactos do nível de serviço esperado e ofertado na fidelização dos clientes

REAd
O mercado varejista farmacêutico passou por inúmeras mudanças nos últimos anos, tornando-se mais competitivo e caracterizado por ofertas de produtos e serviços cada vez mais parecidas entre os diversos concorrentes.
Mikaelli Orlande Gabriel, Anderson Soncini Pelissari, Marcos Paulo Valadares de Oliveira   +2 more
doaj   +1 more source

Evaluation of Daily Physical Activity (DPA) policy implementation in Ontario: surveys of elementary school administrators and teachers

BMC Public Health, 2016
Background School-based structured opportunities for physical activity can provide health-related benefits to children and youth, and contribute to international guidelines recommending 60 min of moderate-to-vigorous physical activity (MVPA) per day.
Kenneth R. Allison, Karen Vu-Nguyen, Bessie Ng, Nour Schoueri-Mychasiw, John J. M. Dwyer, Heather Manson, Erin Hobin, Steve Manske, Jennifer Robertson   +8 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source