Results 81 to 90 of about 177,034 (301)

Space Technology 5 (ST-5) Observations of Field-Aligned Currents: Temporal Variability [PDF]

, 2010
Space Technology 5 (ST-5) is a three micro-satellite constellation deployed into a 300 x 4500 km, dawn-dusk, sun-synchronous polar orbit from March 22 to June 21, 2006, for technology validations.
Le, Guan
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Auroral and sub-auroral phenomena: an electrostatic picture [PDF]

Annales Geophysicae, 2010
Many auroral and sub-auroral phenomena are manifestations of an underlying magnetosphere-ionosphere coupling. In the electrostatic perspective the associated auroral current circuit describes how the generator (often in the magnetosphere) is connected
J. De Keyser, M. Echim
doaj   +1 more source

Polar cap hot patches: enhanced density structures different from the classical patches in the ionosphere [PDF]

, 2017
Based on in situ and ground-based observations, a new type of “polar cap hot patch” has been identified that is different from the classical polar cap enhanced density structure (cold patches).
B.-C. Zhang, Basu, Carlson, Carlson, Carter, Crowley, Crowley, D. R. Themens, Foster, J. C. Foster, J. Moen, Jayachandran, Jin, Jin, Jin, Knudsen, Lockwood, Lockwood, Lockwood, Lockwood, M. Lockwood, MacDougall, Maggiolo, Moen, Nishimura, Oksavik, P. T. Jayachandran, Q.-H. Zhang, Redmon, S.-R. Zhang, Themens, Themens, Thomas, Wang, Weber, Y. Wang, Y.-L. Zhang, Y.-Z. Ma, Z. Y. Xing, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Q.-H., Zou   +47 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Investigation of electrical currents in the auroral ionosphere [PDF]

Two papers are presented on the investigation of electrical currents in the auroral ionosphere: (1) The Relationship Between Field-Aligned Current Carried by Suprathermal Electrons, and the Auroral Arc; and (2) Ionospheric Electrical Currents in the Late
Arnoldy, R. L.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Numerical simulations of current generation and dynamo excitation in a mechanically-forced, turbulent flow

, 2006
The role of turbulence in current generation and self-excitation of magnetic fields has been studied in the geometry of a mechanically driven, spherical dynamo experiment, using a three dimensional numerical computation.
A. N. Kolmogorov, C. B. Forest, C. Canuto, E. J. Spence, F. Cattaneo, G. Glatzmaier, H. Moffatt, K. Krause, M. D. Nornberg, P. H. Roberts, P. W. Terry, R. A. Bayliss, R. O’Connell, S. Childress, T. Cowling, U. Müller, U. Müller   +16 more
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source