Results 71 to 80 of about 24,672 (257)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Field‐aligned current distributions generated by a divergent Hall current

Geophysical Research Letters, 1997
In a horizontally homogeneous high‐latitude ionosphere a steady state Hall current closes within the E region and does not contribute to the interaction between the ionosphere and magnetosphere. When the steady state assumption is given up, Hall currents driven by a non‐zero ∂B/∂t become divergent and must transiently close via the magnetosphere. It is
Stephan C. Buchert, Frank Budnik
openaire   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

The auroral current circuit and field‐aligned currents observed by FAST

Geophysical Research Letters, 1998
FAST observes signatures of small‐scale downward‐going current at the edges of the inverted‐V regions where the primary (auroral) electrons are found. In the winter pre‐midnight auroral zone these downward currents are carried by upward flowing low‐ and medium‐energy (up to several keV) electron beams.
R. C. Elphic, J. W. Bonnell, R. J. Strangeway, L. Kepko, R. E. Ergun, J. P. McFadden, C. W. Carlson, W. Peria, C. A. Cattell, D. Klumpar, E. Shelley, W. Peterson, E. Moebius, L. Kistler, R. Pfaff   +14 more
openaire   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Small-scale Field-aligned Currents in the Magnetopause Boundary Layer

The Astrophysical Journal
Based on high-resolution measurements from the Magnetospheric Multiscale mission from 2015 May to 2018 June, we statistically investigate the properties of small-scale field-aligned currents (SFACs) in the magnetopause boundary layer.
C. M. Wang, S. Y. Huang, Z. G. Yuan, M. Zhou, K. Jiang, S. B. Xu, Q. Y. Xiong, L. T. Lin   +7 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Interplanetary Magnetic Field Bx Effect on Field-Aligned Currents in Different Local Times

Remote Sensing
This study explores the impact of the radial interplanetary magnetic field (IMF) on the strength and latitude of peak field-aligned currents (FACs). FACs are derived through vector magnetic field observations of the Swarm satellite mission.
Yu Sun, Hui Wang
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source