Results 71 to 80 of about 179,377 (341)

Field‐Aligned Currents Induced by Magnetopause Motions Under Pressure Perturbations

open access: yesGeophysical Research Letters
In this work, we identified 65 auroral arcs that stretched out from the equatorward boundary of auroral oval with azimuthal extensions, and investigated their upstream triggering, by utilizing conjunctions between the THEMIS probes and the all‐sky ...
Boyi Wang   +8 more
doaj   +1 more source

On the structure of field-aligned currents in the mid-altitude cusp [PDF]

open access: yesAnnales Geophysicae, 2006
We analyse two crossings of the polar cusp at mid-altitudes (≈4 RE) by Cluster in order to study the structure of field-aligned currents associated with the injection of magnetosheath plasma.
A. Marchaudon   +6 more
doaj   +1 more source

The role of the Hall effect in the global structure and dynamics of planetary magnetospheres: Ganymede as a case study [PDF]

open access: yes, 2015
We present high resolution Hall MHD simulations of Ganymede's magnetosphere demonstrating that Hall electric fields in ion-scale magnetic reconnection layers have significant global effects not captured in resistive MHD simulations. Consistent with local
Collinson, Glyn   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Instability of the magnetosphere-ionosphere convection and formation of auroral arcs [PDF]

open access: yesAnnales Geophysicae, 1994
In this paper we study an instability of the plasma moving towards the Earth near the inner plasma sheet boundary. We include both the interchange instability of the plasma sheet and the magnetosphere-ionosphere interaction instability caused by an ...
A. E. Kozlovsky, W. B. Lyatsky
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Field-aligned currents in nonlinear auroral vortices

open access: yes, 2023
Velocity shears at the boundary layer that forms between a planetary magnetosheath and its magnetosphere can serve as effective voltage generators driving field-aligned currents and powering auroral emissions. Previously, an analytic solution was developed for the field aligned currents and electron precipitation assuming a linear Knight relation as an
Johnson, J., Navarro, A., Wing, S.
openaire   +2 more sources

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