Results 81 to 90 of about 179,377 (341)

Steady‐state field‐aligned currents at Mercury [PDF]

Geophysical Research Letters, 2014
AbstractMagnetic field observations acquired in orbit about Mercury by the MESSENGER spacecraft demonstrate the presence in the planet's northern hemisphere of Birkeland currents that flow to low altitudes. Currents of density 10–30 nA/m2 flow downward at dawn and upward at dusk.
Anderson, Brian J., Johnson, Catherine L., Korth, Haje, Slavin, James A., Winslow, Reka M., Phillips, Roger J., McNutt, Ralph L., Jr., Solomon, Sean C.   +7 more
openaire   +4 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Statistical dependence of auroral ionospheric currents on solar wind and geomagnetic parameters from 5 years of CHAMP satellite data [PDF]

Annales Geophysicae, 2009
The effects of the solar wind dynamic pressure (P), the z component of the solar wind magnetic field (Bz), the merging electric field (Em), season and the Kp index on R1 and R2 field-aligned currents are studied statistically using magnetic field data
L. Juusola, K. Kauristie, O. Amm, P. Ritter   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Auroral and sub-auroral phenomena: an electrostatic picture [PDF]

Annales Geophysicae, 2010
Many auroral and sub-auroral phenomena are manifestations of an underlying magnetosphere-ionosphere coupling. In the electrostatic perspective the associated auroral current circuit describes how the generator (often in the magnetosphere) is connected
J. De Keyser, M. Echim
doaj   +1 more source

Kinetic signatures of the region surrounding the X-line in asymmetric (magnetopause) reconnection [PDF]

, 2016
Kinetic particle-in-cell simulations are used to identify signatures of the electron diffusion region (EDR) and its surroundings during asymmetric magnetic reconnection.
Cassak, P. A., Drake, J. F., Fujimoto, M., Haggerty, C. C., Malakit, K., Phan, T. D., Shay, M. A., Swisdak, M.   +7 more
core   +3 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source