Results 51 to 60 of about 24,672 (257)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Current‐voltage relationship in downward field‐aligned current region [PDF]

Journal of Geophysical Research: Space Physics, 2005
Field‐aligned electrons accelerated upward from the ionosphere to the magnetosphere are the principal charge carriers in the auroral downward field‐aligned current region. Current densities, typically of the order of a few μAm−2, are sustained by potential drops of several 100 V up to a few kV.
Alexandra P. Cran‐McGreehin, Andrew N. Wright   +1 more
openaire   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Field‐Aligned Currents Induced by Magnetopause Motions Under Pressure Perturbations

Geophysical Research Letters
In this work, we identified 65 auroral arcs that stretched out from the equatorward boundary of auroral oval with azimuthal extensions, and investigated their upstream triggering, by utilizing conjunctions between the THEMIS probes and the all‐sky ...
Boyi Wang, Xinyu Xu, Yukitoshi Nishimura, Yen‐Jung Wu, Zhonghua Xu, Primož Kajdic, De‐Sheng Han, Yi Wang, Xueshang Feng   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Instability of the magnetosphere-ionosphere convection and formation of auroral arcs [PDF]

Annales Geophysicae, 1994
In this paper we study an instability of the plasma moving towards the Earth near the inner plasma sheet boundary. We include both the interchange instability of the plasma sheet and the magnetosphere-ionosphere interaction instability caused by an ...
A. E. Kozlovsky, W. B. Lyatsky
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Concerning the conjugation of field-aligned currents

, 2003
It is known that the combined action of convection and pitch-angle diffusion is responsible for the formation of gas pressure distribution in the magnetosphere. Plasma pressure, in turn, determines - within the framework of a given magnetic field model - the density of bulk currents in the magnetosphere.
Mager, O. V., Sedykh, P. A., Ponomarev, E. A., Tashchilin, A. V.   +3 more
openaire   +2 more sources

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source