Results 81 to 90 of about 1,059,681 (219)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Analysis of Sand Dune Migration and Future Trends on the Western Edge of the Kumtag Desert

Land
Sand dune migration, as a typical dynamic process of aeolian geomorphology in arid regions, directly influences regional ecological security and infrastructure development. Focusing on the western edge of the Kumtag Desert, this study uses remote sensing
Fan Yang, Silalan Abudukade, Lishuai Xu, Akida Salam, Xinghua Yang, Wen Huo, Ali Mamtimin, Xinqian Zheng, Yihan Liu, Chenglong Zhou, Mingjie Ma, Fapeng Zhang, Cong Wen   +12 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Effects of Application of N, P And K Alone Or In Combination on Growth, Yield And Curcumin Content of Turmeric(Curcuma Longa L.)

Plant Production Science, 2007
Hikaru Akamine, Amzad Hossain, Yukio Ishimine, Kenichi Yogi, Kazuo Hokama, Yukikazu Iraha, Yoko Aniya   +6 more
doaj   +1 more source

Warming Enhances CO₂ Flux from Saline–Alkali Soils by Intensifying Moisture–Temperature Interactions in the Critical Zone

Land
Saline–alkali soils in arid regions are increasingly recognized as critical yet underrepresented components of the global carbon cycle. However, their CO2 flux dynamics under warming remain poorly understood. In this study, we conducted controlled growth-
Yihan Liu, Fan Yang, Xinchun Liu, Ping Yang, Huiying Ma, Xinqian Zheng, Xinghua Yang, Silalan Abudukad, Jiacheng Gao, Fapeng Zhang   +9 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Improving dust simulation over the Taklimakan Desert through refinement of wind profile parameters in the Revised-MM5 scheme

Atmospheric Environment: X
The Taklimakan Desert, the world's second-largest shifting-sand desert, is a major dust source for northwestern China and East Asia, and its emissions contribute substantially to the global dust cycle. Therefore, improving dust forecasts over this region
Yisilamu Wulayin, Wen Huo, Ali Mamtimin, Fan Yang, Huoqing Li, Junjian Liu, Ailiyaer Aihaiti, Chenxiang Ju, Yu Wang, Meiqi Song, Jian Peng, Haotong Liu   +11 more
doaj   +1 more source