Results 71 to 80 of about 1,059,681 (219)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Spatiotemporal clustering of near-surface wind speed and identification of potential for low-wind-speed resources in Xinjiang, China (2013–2022)

Frontiers in Earth Science
Mastering the intricate spatiotemporal distribution patterns of near-surface wind speed (SWS) holds profound significance for the advancement of regional wind energy resources.
Ailiyaer Aihaiti, Ailiyaer Aihaiti, Junjian Liu, Junjian Liu, Ali Mamtimin, Ali Mamtimin, Yu Wang, Yu Wang, Shunyu Yao, Haotong Liu, Yanbo Shen, Zonghui Liu, Zonghui Liu, Jiacheng Gao, Jiacheng Gao, Meiqi Song, Meiqi Song, Cong Wen, Cong Wen, Yisilamu Wulayin, Yisilamu Wulayin   +20 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Maternal undernutrition during gestation induces enduring genome-wide DNA methylation alterations in the skeletal muscle of postnatal beef cattle

Scientific Reports
Maternal nutrition exerts long-term effects on offspring development, potentially mediated by epigenetic mechanisms. This study aimed to characterize the genome-wide DNA methylation profile of skeletal muscle in postnatal cattle and to determine the long-
Daichi Nishino, Taketo Haginouchi, Takeshi Shimogiri, Susumu Muroya, Kenji Kawabata, Saki Urasoko, Ichiro Oshima, Yutaka Suzuki, Shinobu Yasuo, Takafumi Gotoh   +9 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Corrigendum: Vertical Structure of a Snowfall Event Based on Observations From the Aircraft and Mountain Station in Beijing

Frontiers in Environmental Science, 2022
Yu Huang, Yu Huang, Yu Huang, Delong Zhao, Delong Zhao, Delong Zhao, Yuanmou Du, Yuanmou Du, Yuanmou Du, Yichen Chen, Lei Zhang, Xia Li, Yingying Jing   +12 more
doaj   +1 more source

Impact of florpyrauxifen-benzyl on hybrid rice seeded at different densities

Weed Technology
Florpyrauxifen-benzyl is a postemergence rice herbicide that has reduced rice yield in some situations, and producers are concerned that the impact could be even greater with low rice seeding densities. Therefore, research was conducted in Stoneville, MS,
Thomas W. Eubank, Jason A. Bond, Tom W. Allen, Bobby R. Golden, Victor F. Carey, Darrin M. Dodds, Hunter D. Bowman   +6 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source