Results 61 to 70 of about 887,918 (338)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Comment on "Pinched Flow Fractionation: Continuous Size Separation of Particles Utilizing a Laminar Flow Profile in a Pinched Microchannel"

, 2007
[First paragraph] In a recent paper Yamada et al. propose the novel concept of "pinched flow fractionation" (PFF) for the continuous size separation and analysis of particles in microfabricated lab-on-a-chip devices.
Mortensen, Niels Asger
core   +2 more sources

Fractionation and characterization of starch granules using field-flow fractionation (FFF) and differential scanning calorimetry (DSC)

Analytical and Bioanalytical Chemistry, 2019
Starch is one of the main carbohydrates in food; it is formed by two polysaccharides: amylose and amylopectin. The granule size of starch varies with different botanical origins and ranges from less than 1 μm to more than 100 μm. Some physicochemical and
Catalina Fuentes, In Kang, Jangjae Lee, Dongsup Song, Malin Sjöö, Jaeyeong Choi, Seungho Lee, L. Nilsson   +7 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The different ways to chitosan/hyaluronic acid nanoparticles: templated vs direct complexation. Influence of particle preparation on morphology, cell uptake and silencing efficiency

Beilstein Journal of Nanotechnology, 2019
This study is about linking preparative processes of nanoparticles with the morphology of the nanoparticles and with their efficiency in delivering payloads intracellularly.
Arianna Gennari, Julio M. Rios de la Rosa, Erwin Hohn, Maria Pelliccia, Enrique Lallana, Roberto Donno, Annalisa Tirella, Nicola Tirelli   +7 more
doaj   +1 more source

Application of Af4-Multidetection to Liraglutide in Its Formulation: Preserving and Representing Native Aggregation

Molecules, 2022
Aggregation is among the most critical parameters affecting the pharmacological and safety profile of peptide Active Pharmaceutical Ingredients (APIs).
Valentina Marassi, Marco Macis, Stefano Giordani, Lucia Ferrazzano, Alessandra Tolomelli, Barbara Roda, Andrea Zattoni, Antonio Ricci, Pierluigi Reschiglian, Walter Cabri   +9 more
doaj   +1 more source

Partition-Induced Vector Chromatography in Microfluidic Devices

, 2010
The transport of Brownian particles in a slit geometry in the presence of an arbitrary two-dimensional periodic energy landscape and driven by an external force or convected by a flow field is investigated by means of macrotransport theory.
Bahukudumbi, Balvin, Bhagat, Brenner, Brenner, Burada, Carlo, Choi, Choi, Choi, Davis, Dorfman, Dorfman, Eijkel, Ermak, Evander, Frechette, Gascoyne, German Drazer, Giddings, Giddings, Giddings, Giddings, Han, Han, Happel, Herrmann, Huang, Hughes, Jacobs, Jonáš, Jorge A. Bernate, Kovarik, Kowalkowski, Kralj, Kulrattanarak, Laachi, Li, Mao, Morton, Morton, Pamme, Pamme, Park, Pawar, Risken, Sai, Staben, Takagi, Vastamäki, Wang, Wu, Yamada, Yamada, Zwanzig   +54 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Aptamer–Target–Gold Nanoparticle Conjugates for the Quantification of Fumonisin B1

Biosensors, 2021
Fumonisin B1 (FB1), a mycotoxin classified as group 2B hazard, is of high importance due to its abundance and occurrence in varied crops. Conventional methods for detection are sensitive and selective; however, they also convey disadvantages such as long
Vicente Antonio Mirón-Mérida, Yadira González-Espinosa, Mar Collado-González, Yun Yun Gong, Yuan Guo, Francisco M. Goycoolea   +5 more
doaj   +1 more source

Nitrogen isotope analysis of ammonium and glycine [PDF]

, 2005
Stable isotope techniques can be used as a tool in nitrogen cycling studies of different ecosystems. The studies are based on measurement of the heavy (15N)- to- light (14N) isotopic ratios of nitrogen in different biospheric pools.
Norlin, Elin
core