Concurrent MLL-AF4+ infant ALL in monozygotic twins: a case report [PDF]
Frontiers in PediatricsAcute lymphoblastic leukemia (ALL) is the most common malignancy in childhood, but it is relatively rare in infants. However, infant ALL exhibits distinct biological characteristics and an aggressive course, with a high proportion of cases involving MLL ...
Chenghui Li +4 more
doaj +2 more sources
Cardio-renal protection and mechanisms of the antihypertensive activity of Alcalase-derived moth bean hydrolysate in DOCA-salt induced hypertensive Wistar rats [PDF]
Scientific ReportsHypertension remains a major global health concern, often leading to severe cardiovascular and renal complications. In this study, we investigated the antihypertensive and cardiorenal protective effects of AF4, a bioactive Alcalase derived peptide ...
Nancy Goyal +3 more
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Alcalase–Flavourzyme Red Seaweed Hydrolysates as Antioxidants to Enhance Oxidative Stability of DHA Nanoemulsions [PDF]
FoodsThis study evaluated Palmaria palmata hydrolysates produced using Alcalase® and Flavourzyme® at 1, 2, 3, 4, 5, and 10% (w/w biomass protein, corresponding to AF1-10), and their performance in oil-in-water nanoemulsions under iron-induced oxidation.
Sakhi Ghelichi +3 more
doaj +2 more sources
AF4-to-SAXS: expanded characterization of nanoparticles and proteins at the P12 BioSAXS beamline [PDF]
Journal of Synchrotron RadiationBiological small-angle X-ray scattering (SAXS) is a versatile and powerful technique for investigating the structural and biophysical properties of biologically and pharmaceutically relevant macromolecules and nanoparticles. SAXS offers detailed insights
Stefano Da Vela +12 more
doaj +2 more sources
A One‐Step Workflow for Size‐Based Separation of Extracellular Vesicles With Integrated Surface Marker Detection [PDF]
Journal of Extracellular BiologyExtracellular vesicles (EVs) are released by diverse cell types in biofluids and are increasingly studied in liquid biopsies as diagnostic and prognostic biomarkers for various diseases, including cancer.
Lien Lippens +13 more
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Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein
EBioMedicine, 2015 We have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice.
Gisbert Schneider +2 more
exaly +3 more sources
Clinical characteristics and prognostic analysis of different fusion gene abnormalities in childhood acute lymphoblastic leukaemia [PDF]
Frontiers in OncologyObjectiveThis study aimed to analyze the clinical features and prognostic significance of different fusion gene subtypes in pediatric patients with acute lymphoblastic leukaemia (ALL).MethodsClinical data from 132 childhood patients with ALL diagnosed ...
Rui Fan +9 more
doaj +2 more sources
Bacillus-derived lipopeptides inhibit and eradicate Candida tropicalis Biofilms: An in vitro exploration [PDF]
BiofilmCandida tropicalis is a WHO-prioritised opportunistic fungal pathogen capable of causing superficial-to-systemic fungal infections and forming biofilms on both biotic and abiotic surfaces, such as tissues and medical implants.
Madhuri Madduri +2 more
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Stability of Am(Ⅲ) Colloid and Its Adsorption Behavior on Bentonite Colloids
He huaxue yu fangshe huaxue, 2022 The formation of Am(Ⅲ) colloid and its adsorption behaviors on bentonite colloid were investigated in Beishan 03 groundwater. A series of influencing factors, such as, pH, CO2 concentration in gas atmosphere, ionic strength and temperature, on colloidal ...
LIU Chen +6 more
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Pharmaceuticals, 2022 RNA molecules provide promising new possibilities for the prevention and treatment of viral infections and diseases. The rapid development of RNA biology and medicine requires advanced methods for the purification of RNA molecules, which allow fast and ...
Alesia A. Levanova +5 more
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