Results 1 to 10 of about 20,248 (200)

t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLL [PDF]

Leukemia Research, 2011
The most frequent MLL-gene rearrangement found in leukemia is a reciprocal translocation with AF4 on chromosome 4 resulting in the formation of the MLL-AF4 and the AF4-MLL fusion genes. The oncogenic role of MLL-AF4 is documented but the significance of the reciprocal product - AF4-MLL in leukemia is less clear.
Ashish R Kumar, Qing Yao, Quanzhi Li
exaly   +3 more sources

Concurrent MLL-AF4+ infant ALL in monozygotic twins: a case report [PDF]

Frontiers in Pediatrics
Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood, but it is relatively rare in infants. However, infant ALL exhibits distinct biological characteristics and an aggressive course, with a high proportion of cases involving MLL ...
Chenghui Li, Xin Tong, Jinfeng Yang, Hui Gao, Zhong Li   +4 more
doaj   +2 more sources

Interaction of AF4 wild-type and AF4·MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology? [PDF]

Oncogene, 2004
The human AF4 (ALL-1 fused gene on chromosome 4) gene (4q11) is recurrently involved in reciprocal translocations to the MLL (mixed lineage leukemia) gene (11q23), correlated with high-risk acute lymphoblastic leukemia (ALL) in infants and early childhood. The t(4;11) translocation is one of the most frequent MLL translocations known today. In general,
Soren Moritz, Rolf Marschalek
exaly   +4 more sources

Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia. [PDF]

PLoS ONE, 2015
MLL-rearranged acute lymphoblastic leukemia (ALL) in infants (
Marieke H van der Linden, Lidija Seslija, Pauline Schneider, Emma M C Driessen, Patricia Garrido Castro, Dominique J P M Stumpel, Eddy van Roon, Jasper de Boer, Owen Williams, Rob Pieters, Ronald W Stam   +10 more
doaj   +4 more sources

Cardio-renal protection and mechanisms of the antihypertensive activity of Alcalase-derived moth bean hydrolysate in DOCA-salt induced hypertensive Wistar rats [PDF]

Scientific Reports
Hypertension remains a major global health concern, often leading to severe cardiovascular and renal complications. In this study, we investigated the antihypertensive and cardiorenal protective effects of AF4, a bioactive Alcalase derived peptide ...
Nancy Goyal, Jitesh Singh Rathee, Sachin N. Hajare, S. Gautam   +3 more
doaj   +2 more sources

AF4-to-SAXS: expanded characterization of nanoparticles and proteins at the P12 BioSAXS beamline [PDF]

Journal of Synchrotron Radiation
Biological small-angle X-ray scattering (SAXS) is a versatile and powerful technique for investigating the structural and biophysical properties of biologically and pharmaceutically relevant macromolecules and nanoparticles. SAXS offers detailed insights
Stefano Da Vela, Kim Bartels, Daniel Franke, Dymtro Soloviov, Tobias Gräwert, Dmitry Molodenskiy, Bastian Kolb, Christoph Wilhelmy, Roland Drexel, Florian Meier, Heinrich Haas, Peter Langguth, Melissa A. Graewert   +12 more
doaj   +2 more sources

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Cell Reports, 2017
Summary: Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic ...
Laura Godfrey, Emmanouela Repapi, Marta Tapia   +2 more
exaly   +3 more sources

A One‐Step Workflow for Size‐Based Separation of Extracellular Vesicles With Integrated Surface Marker Detection [PDF]

Journal of Extracellular Biology
Extracellular vesicles (EVs) are released by diverse cell types in biofluids and are increasingly studied in liquid biopsies as diagnostic and prognostic biomarkers for various diseases, including cancer.
Lien Lippens, Niké Guilbert, Sofie Van Dorpe, Sarah Deville, Robin Boiy, Quentin Roux, Nicolaas Lumen, Ilkka Miinalainen, Pekka Rappu, Katrien Vandecasteele, Hannelore Denys, Bruno De Geest, Olivier De Wever, An Hendrix   +13 more
doaj   +2 more sources

Clinical characteristics and prognostic analysis of different fusion gene abnormalities in childhood acute lymphoblastic leukaemia [PDF]

Frontiers in Oncology
ObjectiveThis study aimed to analyze the clinical features and prognostic significance of different fusion gene subtypes in pediatric patients with acute lymphoblastic leukaemia (ALL).MethodsClinical data from 132 childhood patients with ALL diagnosed ...
Rui Fan, Mengmeng Zhao, Peiling Li, Yunjiao Tian, Bao Liu, Xiaojuan Zhu, Xi Chen, Yuanfei Wang, Yanyan Ma, Shujun Li   +9 more
doaj   +2 more sources

Bacillus-derived lipopeptides inhibit and eradicate Candida tropicalis Biofilms: An in vitro exploration [PDF]

Biofilm
Candida tropicalis is a WHO-prioritised opportunistic fungal pathogen capable of causing superficial-to-systemic fungal infections and forming biofilms on both biotic and abiotic surfaces, such as tissues and medical implants.
Madhuri Madduri, Shivaprakash M Rudramurthy, Utpal Roy   +2 more
doaj   +2 more sources