Results 41 to 50 of about 7,144 (173)
Revista Peruana de Ciencias de la Salud, 2023 Objetivo. Describir la frecuencia de los genes de fusión BCR-ABL1, E2A-PBX1, MLL-AF4, y TEL-AML1 en pacientes con leucemia linfoblástica aguda de células B en el Instituto Nacional de Salud del Niño de San Borja, Lima (Perú). Métodos.
Francisco Sánchez-Pinto +4 more
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Oncotarget, 2015 The human 5-lipoxygenase (5-LO), encoded by the ALOX5 gene, is the key enzyme in the formation of pro-inflammatory leukotrienes. ALOX5 gene transcription is strongly stimulated by calcitriol (1α, 25-dihydroxyvitamin D3) and TGFβ (transforming growth factor-β).
Ahmad, Khalil +6 more
openaire +4 more sources
Journal of Hematology & Oncology, 2019 Background Circular RNAs (circRNAs) represent a type of endogenous noncoding RNAs that are generated by back-splicing events and favor repetitive sequences.
Wei Huang +12 more
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Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells. [PDF]
PLoS ONE, 2012 BACKGROUND: The chromosomal translocation t(4;11)(q21;q23) is associated with high-risk acute lymphoblastic leukemia of infants. The resulting AF4•MLL oncoprotein becomes activated by Taspase1 hydrolysis and is considered to promote oncogenic ...
Carolin Bier +9 more
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iScience, 2023 Summary: MLL-rearranged (MLL-r) leukemias are among the leukemic subtypes with poorest survival, and treatment options have barely improved over the last decades.
Julie A. Johannessen +8 more
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The robotic mouse: Unravelling the function of AF4 in the cerebellum
The Cerebellum, 2005 The devastating nature and lack of effective treatments associated with neurodegenerative diseases have stimulated a world-wide search for the elucidation of their molecular basis to which mouse models have made a major contribution. In combination with transgenic and knockout technologies, large-scale mouse mutagenesis is a powerful approach for the ...
Bitoun, E, Davies, K
openaire +2 more sources
Romanian Journal of Laboratory Medicine, 2013 Introducere. Pacienţii cu leucemie acuta limfoblastică (LAL) neonatală prezintă în mod frecvent, o tran- slocaţie particulară, t(4;ll)(q21;q23), care duce la fuziunea genei MLL (mixed lineage leukemia) de pe cromo- zomul 11 cu gena AF4 de pe cromozomul 4.
Ivanov Iuliu C. +7 more
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Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein
EBioMedicine, 2015 We have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice.
Samaneh Sabiani +5 more
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Frontiers in Sensors, 2022 Introduction: Gold nanoparticles (AuNPs) and their conjugates are used for many applications in the field of sensors. Literature lacks procedures able to separate, purify and characterize these species in native conditions without altering them while ...
Junjie Wang +9 more
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Nanoparticle separation with a miniaturized asymmetrical flow field-flow fractionation cartridge
Frontiers in Chemistry, 2015 Asymmetrical Flow Field-Flow Fractionation (AF4) is a separation technique applicable to particles over a wide size range. Despite the many advantages of AF4, its adoption in routine particle analysis is somewhat limited by the large footprint of ...
David eMüller +5 more
doaj +1 more source