Results 41 to 50 of about 9,517 (210)
Functional Studies of MLL-AF4 and a Murinized pSer-variant thereof: MLL-AF4 Impairs the Ribosome Biosynthesis Pathway [PDF]
, 2021 Abstract Background: Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (1).
Anna Lena Siemund +2 more
openaire +1 more source
Romanian Journal of Laboratory Medicine, 2013 Introducere. Pacienţii cu leucemie acuta limfoblastică (LAL) neonatală prezintă în mod frecvent, o tran- slocaţie particulară, t(4;ll)(q21;q23), care duce la fuziunea genei MLL (mixed lineage leukemia) de pe cromo- zomul 11 cu gena AF4 de pe cromozomul 4.
Ivanov Iuliu C. +7 more
doaj +1 more source
The robotic mouse: Unravelling the function of AF4 in the cerebellum
The Cerebellum, 2005 The devastating nature and lack of effective treatments associated with neurodegenerative diseases have stimulated a world-wide search for the elucidation of their molecular basis to which mouse models have made a major contribution. In combination with transgenic and knockout technologies, large-scale mouse mutagenesis is a powerful approach for the ...
Bitoun, E, Davies, K
openaire +2 more sources
Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene [PDF]
, 2009 MLL-AF4 fusion is a hallmark genetic abnormality in infant B-acute lymphoblastic leukemia (B-ALL) known to arise in utero. The cellular origin of leukemic fusion genes during human development is difficult to ascertain.
Menéndez, Pablo +19 more
core +1 more source
Nanoparticle separation with a miniaturized asymmetrical flow field-flow fractionation cartridge
Frontiers in Chemistry, 2015 Asymmetrical Flow Field-Flow Fractionation (AF4) is a separation technique applicable to particles over a wide size range. Despite the many advantages of AF4, its adoption in routine particle analysis is somewhat limited by the large footprint of ...
David eMüller +5 more
doaj +1 more source
Frontiers in Sensors, 2022 Introduction: Gold nanoparticles (AuNPs) and their conjugates are used for many applications in the field of sensors. Literature lacks procedures able to separate, purify and characterize these species in native conditions without altering them while ...
Junjie Wang +9 more
doaj +1 more source
H3K79 Methylation Profiles Define Murine and Human MLL-AF4 Leukemias [PDF]
, 2008 SummaryWe created a mouse model wherein conditional expression of an Mll-AF4 fusion oncogene induces B precursor acute lymphoblastic (ALL) or acute myeloid leukemias (AML).
Feng, Zhaohui +12 more
core +1 more source
Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein
EBioMedicine, 2015 We have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice.
Samaneh Sabiani +5 more
doaj +1 more source
Scientific Reports, 2020 Human plasma is a complex fluid, increasingly used for extracellular vesicle (EV) biomarker studies. Our aim was to find a simple EV-enrichment method for reliable quantification of EVs in plasma to be used as biomarker of disease.
Marija Holcar +7 more
doaj +1 more source
Radical scavenging activity of some natural tropolones by density functional theory
Bulletin of the Chemical Society of Ethiopia, 2017 The ground state neutral geometries of some natural tropolones, i.e. stipitatonic acid (AF1), stipitalide (AF2), stipitaldehydic acid (AF3) and methyl stipitate (AF4) have been optimized by using Density Functional Theory (DFT) at B3LYP/6-31G*, B3LYP/6 ...
A. G. Al-Sehemi +3 more
doaj +1 more source