Results 61 to 70 of about 9,517 (210)

Entrepreneurial Ecosystem Conditions and Sustainable Value Creation: Predictive Evidence From Knowledge‐Intensive Ventures in São Paulo, Brazil

Business Strategy and the Environment, EarlyView.
ABSTRACT Entrepreneurial ecosystems (EEs) are systems shaping innovation and sustainable development, yet limited evidence exists on the relative predictive contribution of their components to sustainable value creation. This study examines associations between six EE dimensions and environmental, social and economic value creation among 245 knowledge ...
Damaris Chieregato Vicentin, Gustavo Hermínio Salati Marcondes de Moraes, Bruno Brandão Fischer, João Henrique Paulino Pires Eustachio, Walter Leal Filho   +4 more
wiley   +1 more source

Genes responsive to AF4-MLL repression characterize AF4-MLL expressing (4;11)⁺ infant ALL patients.

, 2015
(A) Heatmap visualization and hierarchical clustering of primary t(4;11)+ infant ALL samples exhibiting AF4-MLL expression (n = 15, red), or lacking AF4-MLL expression (n = 11, blue), based on the top 50 most differentially expressed genes between both ...
Ronald W. Stam (707004), Owen Williams (707003), Lidija Seslija (706996), Pauline Schneider (706997), Eddy van Roon (707001), Emma M. C. Driessen (706998), Dominique J. P. M. Stumpel (707000), Patricia Garrido Castro (706999), Marieke H. van der Linden (706995), Jasper de Boer (707002), Rob Pieters (294079)   +10 more
core   +1 more source

Reward processing in children with affective dysregulation

JCPP Advances, EarlyView.
Abstract Background Affective dysregulation (AD) in children is characterized by irritability, anger, and frequent intense temper outbursts. Considerable evidence implies altered processing of frustration about missed rewards, but few studies investigated the preceding and thus potentially predictive reward anticipation and initial delivery processing ...
Pascal‐M. Aggensteiner, Francisca Giller, Nathalie Holz, Anna Kaiser, Christine Igel, Sarah Hohmann, Manfred Döpfner, Veit Roessner, Christian Beste, Tobias Banaschewski, Daniel Brandeis, on behalf ofthe ADOPT Consortium   +11 more
wiley   +1 more source

Fractionation‐Free Protein Corona Quantification Through Synchrotron‐Based Small‐Angle X‐ray Scattering

Small Methods, EarlyView.
A fractionation‐free SAXS approach quantifies protein corona formation on silica nanoparticles under native conditions. By deconvoluting scattering from free and bound proteins, adsorbed mass is directly determined in simple and complex media. The method resolves adsorption regimes and thermodynamics, establishing non‐invasive, in situ characterization
Juliana T. T. Carvalho, Caroline E. P. Silva, Lindomar J. C. Albuquerque, Antônio A. Malfatti‐Gasperini, Liming Wang, Nathan P. Cowieson, Mateus B. Cardoso   +6 more
wiley   +1 more source

Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis

Haematologica, 2019
B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1+ (MLL-AF4+) infant
Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla, Marta Gut, Maria G. Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menendez, Ronald W. Stam   +17 more
doaj   +1 more source

AFF4 Loss Compromises Osteogenesis of Orofacial Mesenchymal Stem Cells During Alveolar Bone Repair via AMPK‐Mediated Mitophagy

Cell Proliferation, EarlyView.
Compromised alveolar socket healing following tooth extraction upon Aff4 knockout is caused by suppressed osteogenic capacity of orofacial mesenchymal stem cells, which results from defective AMPK‐mediated mitophagy. ABSTRACT Repair of maxillofacial bone defects presents significant clinical challenges.
Li Zhu, Shuo Chen, Guowen Luo, Tingyue Zhang, Hengyi Lin, Yiling Chen, Chenchen Zhou, Shujuan Zou   +7 more
wiley   +1 more source

Assessment of the Effects of Structural Modification of Gastrodia elata Polysaccharide on Anti-Breast Cancer Activity Using Asymmetrical Flow Field-Flow Fractionation

Molecules, 2023
Gastrodia elata (“Tian Ma” in Chinese) is used as a food and medical ingredient in traditional Chinese medicine. In this study, to enhance the anti-breast cancer activity of Gastrodia elata polysaccharide (GEP), GEPs were modified via sulfidation (SGEP ...
Xiaoying Liu, Yuwei Dou, Tingting Hao, Mu Wang, Liu Yang, Hailiang Zheng, Hongmei Liu, Haiyang Dou   +7 more
doaj   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Manual Remodelling of AF4 and O2 Electrodes in Schizophrenia [PDF]

, 2019
Manual recreation of AF4 and O2 electrodes in schizophrenia. This study aims to: a) Know the EEG signals in the brain in humans, b) find out how manual rearrangements of the AF4 electrode and O2 electrode in schizophrenic patients and c) find out how the
Gunawan, Redi; SMP IQU AL-BAHJAH CIREBON, Nursuprianah, Indah; IAIN Syekh Nurjati Cirebon   +1 more
core   +1 more source

Dietary modulation of antimicrobial peptides (HAMP and LEAP2) in Chinook salmon (Oncorhynchus tshawytscha) fed a phytobiotic functional diet: Integrated genomic characterisation and tissue‐specific expression

Journal of Fish Biology, EarlyView.
Abstract Antimicrobial peptides (AMPs) are key components of the innate immune system in fish, providing rapid protection against microbial pathogens. Among these, the liver‐expressed antimicrobial peptides (LEAPs), comprising LEAP‐1 (hepcidin; HAMP) and LEAP‐2, play central roles in host defence and iron regulation.
Roberta Marcoli, Jane E. Symonds, Seumas P. Walker, Cesar Lopez, Mark A. Preece, Christopher Battershill, Steve Bird   +6 more
wiley   +1 more source