Results 61 to 70 of about 7,144 (173)
AF4 (ALL1 fused gene from chromosome 4) - AFF1 (AF4/FMR2 family, member 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on AFF1 (AF4/FMR2 family, member 1), with data on DNA, on the protein encoded, and where the gene is implicated.
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European Journal of Haematology, Volume 117, Issue 1, Page 24-41, July 2026.ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese +12 more
wiley +1 more source
Targeting the Menin–KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation
European Journal of Haematology, Volume 117, Issue 1, Page 132-143, July 2026.ABSTRACT Acute leukemias characterized by a shared epigenetic dependency on the menin–KMT2A axis rely on aberrant HOX‐driven transcriptional programs that sustain leukemic self‐renewal and impair differentiation. This dependency is most evident in KMT2A‐rearranged and NPM1‐mutated acute myeloid leukemia (AML), but also extends to other HOX‐dependent ...
Antonella Bruzzese +12 more
wiley +1 more source
Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation
Cellular Oncology, 2019 The t(4;11)(q21;q23) translocation characterizes a form of acute lymphoblastic leukemia with a poor prognosis. It results in a fusion gene encoding a chimeric transcription factor, MLL-AF4, that deregulates gene expression through a variety of still controversial mechanisms.
Fioretti T. +6 more
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Brain and Behavior, Volume 16, Issue 6, June 2026.Athletes with neurological disorders showed increased supplementary motor and premotor area activation during soccer‐specific motor preparation with respect to healthy controls, particularly with the affected limb, suggesting compensatory neural strategies that support motor control and performance.
Francisco Echevarría‐Lasaga +5 more
wiley +1 more source
General Psychiatry, Volume 39, Issue 3, June 2026.ABSTRACT Background Major depressive disorder (MDD) is characterised by interhemispheric functional imbalance, yet the neuromodulatory mechanisms underlying its correction remain poorly understood. Repetitive transcranial magnetic stimulation (rTMS) has shown promise in restoring hemispheric balance, but evidence regarding its effects on alpha‐band ...
Yaqun Chen +7 more
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Haematologica, 2019 B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1+ (MLL-AF4+) infant
Antonio Agraz-Doblas +17 more
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Molecules, 2023 Gastrodia elata (“Tian Ma” in Chinese) is used as a food and medical ingredient in traditional Chinese medicine. In this study, to enhance the anti-breast cancer activity of Gastrodia elata polysaccharide (GEP), GEPs were modified via sulfidation (SGEP ...
Xiaoying Liu +7 more
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Health Science Reports, Volume 9, Issue 6, June 2026.ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra +7 more
wiley +1 more source
Nanomaterials, 2019 Graphene-based materials are highly interesting in virtue of their excellent chemical, physical and mechanical properties that make them extremely useful as privileged materials in different industrial applications.
Juan Amaro-Gahete +7 more
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