Results 71 to 80 of about 7,188 (177)

The role of DOT1L in MLL-AF4 leukaemia

, 2018
DOT1L is a methyltransferase which has been shown to methylate H3K79 (Ng et al. 2002; Feng et al. 2002; Lacoste et al. 2002). DOT1L and H3K79me have been shown to be involved in active transcription and in particular has been shown to be important for MLL-AF4 leukaemia, where high levels of H3K79me are found at MLL-AF4 gene targets (Krivtsov et al ...
openaire   +2 more sources

MLL-AF4+ infant leukemia: a microRNA affair [PDF]

Blood, 2021
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Ultrafiltration and size exclusion chromatography combined with asymmetrical-flow field-flow fractionation for the isolation and characterisation of extracellular vesicles from urine

Journal of Extracellular Vesicles, 2018
Extracellular vesicles (EVs) have a great potential in clinical applications. However, their isolation from different bodily fluids and their characterisation are currently not optimal or standardised.
Eline Oeyen, Kurt Van Mol, Geert Baggerman, Hanny Willems, Kurt Boonen, Christian Rolfo, Patrick Pauwels, An Jacobs, Karin Schildermans, William C Cho, Inge Mertens   +10 more
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RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

Cell Reports, 2013
The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans ...
Adam C. Wilkinson, Erica Ballabio, Huimin Geng, Phillip North, Marta Tapia, Jon Kerry, Debabrata Biswas, Robert G. Roeder, C. David Allis, Ari Melnick, Marella F.T.R. de Bruijn, Thomas A. Milne   +11 more
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Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)/MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia

Advances in Hematology, 2011
Translocation t(4;11)(q21;q23) leading to formation of MLL-AF4 fusion gene is found in about 10% of newly diagnosed B-cell acute lymphoblastic leukemia (ALL) in adult patients.
F. Marchesi, K. Girardi, G. Avvisati
doaj   +1 more source

LAF4 (lymphoid nuclear protein related to AF4) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on LAF4 (lymphoid nuclear protein related to AF4), with data on DNA, on the protein encoded, and where the gene is implicated.
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Parâmetros genéticos para produção de leite no dia do controle de vacas da raça Holandesa utilizando modelos de análises de fatores e componentes principais

Ciência Rural, 2015
Objetivou-se comparar um modelo multi-característica padrão com modelos de análise de fatores (AF) e de componentes principais (CP) para estimar parâmetros genéticos para a produção de leite no dia do controle (PLDC) de vacas da raça Holandesa. O arquivo
Mariana de Almeida Dornelles, Paulo Roberto Nogara Rorato, Fernanda Cristina Breda, Carlos Bondan, Luis Telo Lavadinho da Gama, Jaime Araujo Cobuci, Giovani Luis Feltes, Vanessa Tomazetti Michelotti, Alan Miranda Prestes   +8 more
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Venetoclax in combination with chidamide and azacitidine for the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia with the MLL-AF4 gene: a case report and literature review

Frontiers in Immunology
B-cell acute lymphoblastic leukemia (B-ALL) with the MLL-AF4 fusion gene has a poor prognosis, and the mortality rate exceeds 90%, particularly in cases of extramedullary relapse (EMR).
Xuelian Jin, Zhigang Liu, Yu Wu, Jie Ji
doaj   +1 more source

Asymmetric flow field-flow fractionation for the monitoring of red wine colloids and macromolecules throughout the winemaking process

Frontiers in Soft Matter
Colloids and macromolecules are the major compounds in wine particulate matter and play an important role in many wine properties that change during the winemaking process. However, methodologies are lacking to characterize and quantify the changes these
Daniel E. Osorio-Macías, Daniel E. Osorio-Macías, Raúl Ferrer-Gallego, Jaeyeong Choi, Björn Bergenståhl   +4 more
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MLL-AF4 fusion transcripts in Acute Lymphocytic Leukemia patientsin Children hospital of Tabriz

Iranian South Medical Journal, 2014
Background: MLL-AF4 positive Leukemias comprise about 50-70% of acute lymphoid leukemias in children and about 5% of adolescents and adults Despite recent advances in the treatment of hematologic malignancies of children with ALL in particular, but it ...
Amir Monfaredan, Seyyed Mahmood Tabatabaei, Nahideh Karimian Fathi, Azim Rezamand   +3 more
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