Results 71 to 80 of about 7,144 (173)

Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene [PDF]

Journal of Experimental Medicine, 2009
MLL-AF4 fusion is a hallmark genetic abnormality in infant B-acute lymphoblastic leukemia (B-ALL) known to arise in utero. The cellular origin of leukemic fusion genes during human development is difficult to ascertain. The bone marrow (BM) microenvironment plays an important role in the pathogenesis of several hematological malignances. BM mesenchymal
Menendez, Pablo, Catalina, Purificacion, Rodriguez, Rene, Melen, Gustavo, Bueno, Clara, Arriero, Mar, García-Sanchez, Felix, Lassaletta, Alvaro, García Sanz, Ramón, García-Castro, Javier   +9 more
openaire   +4 more sources

Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development

Cell Reports, 2016
MLL-AF4+ infant B cell acute lymphoblastic leukemia is characterized by an early onset and dismal survival. It initiates before birth, and very little is known about the early stages of the disease’s development.
Neil A. Barrett, Camille Malouf, Chrysa Kapeni, Wendi A. Bacon, George Giotopoulos, Sten Eirik W. Jacobsen, Brian J. Huntly, Katrin Ottersbach   +7 more
doaj   +1 more source

Rational Design and Development of Organic Afterglow Nanoparticles for Image‐Guided Interventions

Small Methods, Volume 10, Issue 12, 23 June 2026.
This review outlines the rational design, synthesis, and standardized characterization of organic afterglow nanoparticles for biomedical imaging and therapy. Mechanistic insights into chemically initiated electron exchange luminescence and reactive oxygen species‐mediated processes are connected to molecular engineering and nanoparticle fabrication ...
Asma Harun, Isabella Vasquez, Hannah Bowman, Robert Posey, Zhongkui Hong, Joshua Tropp, Indrajit Srivastava   +6 more
wiley   +1 more source

Challenges in Determining the Size Distribution of Nanoparticles in Consumer Products by Asymmetric Flow Field-Flow Fractionation Coupled to Inductively Coupled Plasma-Mass Spectrometry: The Example of Al₂O₃, TiO₂, and SiO₂ Nanoparticles in Toothpaste

Separations, 2018
According to the current European regulation on cosmetics, any ingredient present as a nanomaterial should be indicated in the ingredient list. There is a need for analytical methods capable of determining the size of the relevant ingredients and thus ...
Manuel Correia, Toni Uusimäki, Allan Philippe, Katrin Loeschner   +3 more
doaj   +1 more source

Unlocking the Functionalization and Reactivity of Ethylene Bridges in [2.2]Paracyclophanes: Strategies and Challenges

European Journal of Organic Chemistry, Volume 29, Issue 20, 27 May 2026.
Bridging the gap. Beyond deck functionalization, the ethylene bridges of [2.2]paracyclophanes offer a largely unexploited reactivity landscape. This review showcases strategies to functionalize these bridges and leverage them to build novel cyclophane architectures.
Rongyu Sun, Tamara Ye, Laurent Micouin, Erica Benedetti   +3 more
wiley   +1 more source

Synthesis and modification of octafluoro[2.2]paracyclophane (parylene AF4)

Organic Chemistry Frontiers, 2014
Parylenes are a class of organic compounds which have gained significant attention due to their application as coatings in areas such as medical devices and electronics. This review highlights the development of synthetic pathways to Octafluoro[2.2]Paracyclophane, commonly referred to as parylene AF4.
Hicks, Craig, Duffy, Brendan, Hargaden, Gráinne   +2 more
openaire   +4 more sources

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

Comparison of Miniaturized and Conventional Asymmetrical Flow Field-Flow Fractionation (AF4) Channels for Nanoparticle Separations

Separations, 2017
The performance of a miniaturized channel for the separation of polymer and metal nanoparticles (NP) using Asymmetrical Flow Field-Flow Fractionation (AF4) was investigated and compared with a conventional AF4 system.
Zengchao You, Florian Meier, Steffen Weidner   +2 more
doaj   +1 more source

Molecular-genetic methods for diagnostics of acute leukemia

Фактори експериментальної еволюції організмів, 2013
Aims. Acute leukemia - heterogeneous group of diseases characterized by the rapid growth of abnormal uncontrolled proliferation of hematopoietic stem cells or progenitor cells.
M. V. Dybkov, M. P. Zavelevich, D. F. Gluzman, L. O. Polishchuk, S. S. Maliuta, G. D. Telegeev   +5 more
doaj  

Two promising Bacillus-derived antifungal lipopeptide leads AF4 and AF5 and their combined effect with fluconazole on the in vitro Candida glabrata biofilms

Frontiers in Pharmacology
Introduction:Candida species are endowed with the ability to produce biofilms, which is one of the causes of pathogenicity, as biofilms protect yeasts from antifungal drugs. Candida glabrata (Nakaseomyces glabrata) is one of the most prevalent pathogenic
Madduri Madhuri, Shivaprakash M. Rudramurthy, Utpal Roy   +2 more
doaj   +1 more source