Results 1 to 10 of about 12,212 (181)

MLL-AF4 and a murinized pSer-variant thereof are turning on the nucleolar stress pathway [PDF]

Cell & Bioscience, 2022
Background Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (Lin et ...
Anna Lena Siemund, Thomas Hanewald, Eric Kowarz, Rolf Marschalek   +3 more
doaj   +6 more sources

MLL-AF4 upregulates 5-lipoxygenase expression in t(4;11) leukemia cells via the ALOX5 core promoter [PDF]

Frontiers in Pharmacology
5-Lipoxygenase (5-LO), encoded by the gene ALOX5, is implicated in several pathologies. As key enzyme in leukotriene biosynthesis, 5-LO plays a central role in inflammatory diseases, but the 5-LO pathway has also been linked to development of certain ...
Dieter Steinhilber, Rolf Marschalek, Maximilian Molitor   +2 more
exaly   +5 more sources

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia. [PDF]

Blood, 2022
Abstract The fusion gene MLL/AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukemia. Relapse can be associated with a lineage switch from acute lymphoblastic to acute myeloid leukemia, resulting in poor clinical outcomes caused by resistance to chemotherapies and immunotherapies.
Tirtakusuma R, Szoltysek K, Milne P, Grinev VV, Ptasinska A, Chin PS, Meyer C, Nakjang S, Hehir-Kwa JY, Williamson D, Cauchy P, Keane P, Assi SA, Ashtiani M, Kellaway SG, Imperato MR, Vogiatzi F, Schweighart EK, Lin S, Wunderlich M, Stutterheim J, Komkov A, Zerkalenkova E, Evans P, McNeill H, Elder A, Martinez-Soria N, Fordham SE, Shi Y, Russell LJ, Pal D, Smith A, Kingsbury Z, Becq J, Eckert C, Haas OA, Carey P, Bailey S, Skinner R, Miakova N, Collin M, Bigley V, Haniffa M, Marschalek R, Harrison CJ, Cargo CA, Schewe D, Olshanskaya Y, Thirman MJ, Cockerill PN, Mulloy JC, Blair HJ, Vormoor J, Allan JM, Bonifer C, Heidenreich O, Bomken S.   +56 more
europepmc   +6 more sources

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Cell Reports, 2017
Summary: Understanding the underlying molecular mechanisms of defined cancers is crucial for effective personalized therapies. Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic ...
Huimin Geng, Olaf Heidenreich, Anindita Roy   +2 more
exaly   +4 more sources

RNA-binding proteins of KHDRBS and IGF2BP families control the oncogenic activity of MLL-AF4 [PDF]

Nature Communications, 2022
The establishment of a mouse model of MLL-AF4-induced leukaemia is a challenge as the introduction of fusion gene of human MLL-AF4 does not cause leukaemia in mice.
Hiroshi Okuda, Ryo Miyamoto, Satoshi Takahashi, Takeshi Kawamura, Juri Ichikawa, Ibuki Harada, Tomohiko Tamura, Akihiko Yokoyama   +7 more
doaj   +2 more sources

The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae [PDF]

iScience, 2023
Summary: MLL-rearranged (MLL-r) leukemias are among the leukemic subtypes with poorest survival, and treatment options have barely improved over the last decades.
Julie A. Johannessen, Miriam Formica, Aina Louise C. Haukeland, Nora Rojahn Bråthen, Amani Al Outa, Miriam Aarsund, Marc Therrien, Jorrit M. Enserink, Helene Knævelsrud   +8 more
doaj   +2 more sources

MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia [PDF]

Nature Communications, 2023
Aberrant enhancer activation is a key mechanism driving oncogene expression in many cancers. While much is known about the regulation of larger chromosome domains in eukaryotes, the details of enhancer-promoter interactions remain poorly understood ...
Nicholas T. Crump, Alastair L. Smith, Laura Godfrey, Ana M. Dopico-Fernandez, Nicholas Denny, Joe R. Harman, Joseph C. Hamley, Nicole E. Jackson, Catherine Chahrour, Simone Riva, Siobhan Rice, Jaehoon Kim, Venkatesha Basrur, Damian Fermin, Kojo Elenitoba-Johnson, Robert G. Roeder, C. David Allis, Irene Roberts, Anindita Roy, Huimin Geng, James O. J. Davies, Thomas A. Milne   +21 more
doaj   +2 more sources

The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis. [PDF]

Leukemia, 2022
AbstractDespite recent advances in therapeutic approaches, patients with MLL-rearranged leukemia still have poor outcomes. Here, we find that the RNA-binding protein IGF2BP3, which is overexpressed in MLL-translocated leukemia, strongly amplifies MLL-Af4-mediated leukemogenesis.
Tran TM, Philipp J, Bassi JS, Nibber N, Draper JM, Lin TL, Palanichamy JK, Jaiswal AK, Silva O, Paing M, King J, Katzman S, Sanford JR, Rao DS.   +13 more
europepmc   +6 more sources

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program [PDF]

Nature Communications, 2021
It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicates ...
Siobhan Rice, Thomas Jackson, Nicholas T. Crump, Nicholas Fordham, Natalina Elliott, Sorcha O’Byrne, Maria del Mar Lara Fanego, Dilys Addy, Trisevgeni Crabb, Carryl Dryden, Sarah Inglott, Dariusz Ladon, Gary Wright, Jack Bartram, Philip Ancliff, Adam J. Mead, Christina Halsey, Irene Roberts, Thomas A. Milne, Anindita Roy   +19 more
doaj   +2 more sources

Concurrent MLL-AF4+ infant ALL in monozygotic twins: a case report [PDF]

Frontiers in Pediatrics
Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood, but it is relatively rare in infants. However, infant ALL exhibits distinct biological characteristics and an aggressive course, with a high proportion of cases involving MLL ...
Chenghui Li, Xin Tong, Jinfeng Yang, Hui Gao, Zhong Li   +4 more
doaj   +2 more sources