P314: THERAPEUTICALLY TARGETING THE UNIQUE BARCODE OF MLL/AF4
HemaSphere, 2022 R. Cameron +3 more
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Targeting IGF2BP3 enhances antileukemic effects of menin-MLL inhibition in MLL-AF4 leukemia. [PDF]
Blood Adv: RNA-binding proteins (RBPs) are emerging as a novel class of therapeutic targets in cancer, including in leukemia, given their important role in posttranscriptional gene regulation, and have the unexplored potential to be combined with existing ...
Lin TL +10 more
europepmc +2 more sources
Functional Studies of MLL-AF4 and a Murinized pSer-variant thereof: MLL-AF4 Impairs the Ribosome Biosynthesis Pathway [PDF]
, 2021 Abstract Background: Recent pathomolecular studies on the MLL-AF4 fusion protein revealed that the murinized version of MLL-AF4, the MLL-Af4 fusion protein, was able to induce leukemia when expressed in murine or human hematopoietic stem/progenitor cells (1).
Anna Lena Siemund +2 more
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Identification of genes transcriptionally responsive to the loss of MLL fusions in MLL-rearranged acute lymphoblastic leukemia. [PDF]
PLoS ONE, 2015 MLL-rearranged acute lymphoblastic leukemia (ALL) in infants (
Marieke H van der Linden +10 more
doaj +1 more source
Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation. [PDF]
Cell Oncol (Dordr), 2019 The t(4;11)(q21;q23) translocation characterizes a form of acute lymphoblastic leukemia with a poor prognosis. It results in a fusion gene encoding a chimeric transcription factor, MLL-AF4, that deregulates gene expression through a variety of still ...
Fioretti T +6 more
europepmc +2 more sources
Targeting IGF2BP3 Enhances Anti-Leukemic Effects of Menin-MLL Inhibition in MLL-AF4 Leukemia [PDF]
, 2023 Background: MLL-rearranged leukemias are a clinically challenging and biologically unique subtype of leukemias associated with poor prognosis.
Cohen, Amanda +10 more
core +1 more source
Reconstructing the Disease Model and Epigenetic Networks for MLL-AF4 Leukemia [PDF]
Cancer Cell, 2008 The lack of a proper animal model has impeded understanding of the molecular mechanism of leukemia associated with the MLL-AF4 fusion. In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L.
Zeisig, B B +3 more
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Revista Peruana de Ciencias de la Salud, 2023 Objetivo. Describir la frecuencia de los genes de fusión BCR-ABL1, E2A-PBX1, MLL-AF4, y TEL-AML1 en pacientes con leucemia linfoblástica aguda de células B en el Instituto Nacional de Salud del Niño de San Borja, Lima (Perú). Métodos.
Francisco Sánchez-Pinto +4 more
doaj +1 more source
Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells. [PDF]
PLoS ONE, 2012 BACKGROUND: The chromosomal translocation t(4;11)(q21;q23) is associated with high-risk acute lymphoblastic leukemia of infants. The resulting AF4•MLL oncoprotein becomes activated by Taspase1 hydrolysis and is considered to promote oncogenic ...
Carolin Bier +9 more
doaj +1 more source
HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
eLife, 2021 Leukemic oncoproteins cause uncontrolled self-renewal of hematopoietic progenitors by aberrant gene activation, eventually causing leukemia. However, the molecular mechanism underlying aberrant gene activation remains elusive.
Satoshi Takahashi +9 more
doaj +1 more source