Results 41 to 50 of about 12,212 (181)

Blocking SETD2 Enhances the Therapeutic Efficiency of Menin Inhibitor in MLL-Fusion Leukemia. [PDF]

Cancer Sci
Combined SETD2 and menin inhibitors make synergistic effects against MLL‐fusion leukemia; the combination therapy reduces the expression of target genes through blocking transcription elongation and initiation. ABSTRACT During transcriptional elongation, the histone methyltransferase SETD2 binds to RNA polymerase II and deposits trimethylation marks at
Li A, Zhang Y, Li Z, Liu A, Zhang L, Gao S, Lin X, Liu X, Li H, Jin G, Xu B.   +10 more
europepmc   +2 more sources

Targeting the MLL complex in acute leukemia [PDF]

, 2014
Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core   +1 more source

One Step Forward in the Challenging Arena of MLL-AF4 Leukemia [PDF]

Cancer Cell, 2016
MLL-AF4 leukemia is the predominant infant acute leukemia and has a poor prognosis. No current experimental models accurately reflect the human disease. Lin et al., in this issue of Cancer Cell, describe their model that recapitulates multiple key aspects of this aggressive disease, facilitating future mechanistic and preclinical studies.
openaire   +3 more sources

Prognostic value and outcome for acute lymphocytic leukemia in children with MLL rearrangement: a case-control study

BMC Cancer, 2022
Purpose To evaluate the prognostic factors and outcome for acute lymphoblastic leukemia (ALL) in children with MLL rearrangement (MLL-r). Methods A total of 124 pediatric patients who were diagnosed with ALL were classified into two groups based on the ...
Kun-yin Qiu, Dun-hua Zhou, Xiong-yu Liao, Ke Huang, Yang Li, Hong-gui Xu, Wen-jun Weng, Lu-hong Xu, Jian-pei Fang   +8 more
doaj   +1 more source

TGFv/SMAD signalling modulates MLL and MLL-AF4 mediated 5-lipoxygenase promoter activation

, 2022
S.60-675-Lipoxygenase (5-LO) catalyzes the initial two steps of the conversion of arachidonic acid to leukotrienes which represent a group of pro-inflammatory lipid mediators involved in immune defense reactions as well as inflammation, allergy and ...
Marschalek, R., Hegewald, A.B., Müller-McNicoll, M., Suess, B., Steinhilber, D., Saul, M.J., Groher, F.   +6 more
core   +2 more sources

Infant acute leukemia with lineage switch at relapse expressing a novel t(4;11)(q21;q23) MLL-AF4 fusion transcript

Romanian Journal of Laboratory Medicine, 2013
Introducere. Pacienţii cu leucemie acuta limfoblastică (LAL) neonatală prezintă în mod frecvent, o tran- slocaţie particulară, t(4;ll)(q21;q23), care duce la fuziunea genei MLL (mixed lineage leukemia) de pe cromo- zomul 11 cu gena AF4 de pe cromozomul 4.
Ivanov Iuliu C., Jitam Daniela, Grigore Georgiana E., Zlei Mihaela, Ivanov Anca V., Dumitraş Silvia, Carasevici Eugen, Miron Ingritli C.   +7 more
doaj   +1 more source

Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysis

Haematologica, 2019
B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1+ (MLL-AF4+) infant
Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla, Marta Gut, Maria G. Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menendez, Ronald W. Stam   +17 more
doaj   +1 more source

RUNX1 Is a Key Target in t(4;11) Leukemias that Contributes to Gene Activation through an AF4-MLL Complex Interaction

Cell Reports, 2013
The Mixed Lineage Leukemia (MLL) protein is an important epigenetic regulator required for the maintenance of gene activation during development. MLL chromosomal translocations produce novel fusion proteins that cause aggressive leukemias in humans ...
Adam C. Wilkinson, Erica Ballabio, Huimin Geng, Phillip North, Marta Tapia, Jon Kerry, Debabrata Biswas, Robert G. Roeder, C. David Allis, Ari Melnick, Marella F.T.R. de Bruijn, Thomas A. Milne   +11 more
doaj   +1 more source

Generation of a human induced pluripotent stem cell line harboring the infant leukemia-associated fusion gene, KMT2A-AFF1 (IMSUTi002-A-2)

Stem Cell Research, 2023
KMT2A-AFF1 (MLL-AF4), formed by chromosomal translocation t(4;11), is observed specifically in infant pro-B acute lymphoblastic leukemia, and the main driver of leukemogenesis.
Masayuki Takahashi
doaj   +1 more source

NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters. [PDF]

PLoS ONE, 2011
BackgroundDifferent histone post-translational modifications (PTMs) are crucial in the regulation of chromatin, including methylations of H3 at Lysine 4 by the MLL complex.
Andrea Fossati, Diletta Dolfini, Giacomo Donati, Roberto Mantovani   +3 more
doaj   +1 more source