Revista Peruana de Ciencias de la Salud, 2023 Objetivo. Describir la frecuencia de los genes de fusión BCR-ABL1, E2A-PBX1, MLL-AF4, y TEL-AML1 en pacientes con leucemia linfoblástica aguda de células B en el Instituto Nacional de Salud del Niño de San Borja, Lima (Perú). Métodos.
Francisco Sánchez-Pinto +4 more
doaj +2 more sources
Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements.
Cell Rep, 2021 Summary Infant MLL-AF4-driven acute lymphoblastic leukemia (ALL) is a devastating disease with dismal prognosis. A lack of understanding of the unique biology of this disease, particularly its prenatal origin, has hindered improvement of survival.
Symeonidou V +8 more
europepmc +2 more sources
HOXA9/IRX1 expression pattern defines two subgroups of infant MLL-AF4-driven acute lymphoblastic leukemia. [PDF]
Exp Hematol, 2021 Highlights • We identified two sub-groups of infant MLL-AF4-driven ALL, iALL-HOXA9, and iALL-IRX1.• The subgroups exhibit mutually exclusive expression of HOXA9/HOXA10 and IRX1.• The transcriptional profile of iALL-IRX1 patients revealed a more ...
Symeonidou V, Ottersbach K.
europepmc +2 more sources
The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment. [PDF]
Blood, 2017 Abstract Chromosome rearrangements involving the mixed-lineage leukemia gene (MLL) create MLL-fusion proteins, which could drive both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The lineage decision of MLL-fusion leukemia is influenced by the fusion partner and microenvironment.
Lin S +4 more
europepmc +4 more sources
PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia
bioRxiv, 2022 Aberrant enhancer activation has been identified as a key mechanism driving oncogene expression in many cancers. Here we use TOPmentation (Transcription factor-OPtimized ChIPmentation) to probe enhancer usage in primary MLL-rearranged acute lymphoblastic
Crump NT +13 more
europepmc +2 more sources
Only Hematopoietic Stem and Progenitor Cells from Cord Blood Are Susceptible to Malignant Transformation by MLL-AF4 Translocations. [PDF]
Cancers (Basel), 2020 Mixed lineage leukemia (MLL) (KMT2A) rearrangements (KMT2Ar) play a crucial role in leukemogenesis. Dependent on age, major differences exist regarding disease frequency, main fusion partners and prognosis.
Secker KA +9 more
europepmc +2 more sources
bioRxiv, 2023 Infants and children with MLL-AF4+ leukemia have an urgent need for more efficient and less aggressive therapy. In this study, we studied three microRNAs that are downregulated in MLL-AF4+ B-cell precursor acute lymphoblastic leukemia (BCP-ALL): miR-194,
Malouf C +9 more
europepmc +2 more sources
IGF2BP3 remodels the microRNA targeting landscape in MLL-AF4 leukemia
bioRxivInsulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3/I3) is a multi-domain RNA-binding protein required for MLL-AF4–driven leukemogenesis, but its mechanism of action remains enigmatic.
L. Kabbani +10 more
semanticscholar +3 more sources
Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein
EBioMedicine, 2015 We have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice.
Gisbert Schneider +2 more
exaly +3 more sources
Crosstalk between 14-3-3θ and AF4 enhances MLL-AF4 activity and promotes leukemia cell proliferation. [PDF]
Cell Oncol (Dordr), 2019 The t(4;11)(q21;q23) translocation characterizes a form of acute lymphoblastic leukemia with a poor prognosis. It results in a fusion gene encoding a chimeric transcription factor, MLL-AF4, that deregulates gene expression through a variety of still ...
Fioretti T +6 more
europepmc +2 more sources