Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development [PDF]
Cell Reports, 2016 MLL-AF4+ infant B cell acute lymphoblastic leukemia is characterized by an early onset and dismal survival. It initiates before birth, and very little is known about the early stages of the disease’s development.
Neil A. Barrett +7 more
doaj +2 more sources
Methylation-mediated repression of microRNA-143 enhances MLL–AF4 oncogene expression [PDF]
Oncogene, 2011 Fusion proteins containing the amino terminus of mixed lineage leukemia (MLL) are common in acute lymphoblastic leukemia (ALL) due to translocations. The MLL-AF4 fusion protein is generated by the translocation t(4;11)(q21;q23), and t(4;11)-positive ALL patients (MLL-AF4 ALL), have a notoriously poorer prognosis compared with patients with other MLL ...
L, Dou +6 more
exaly +3 more sources
The role of DOT1L in MLL-AF4 leukaemia [PDF]
, 2018 DOT1L is a methyltransferase which has been shown to methylate H3K79 (Ng et al. 2002; Feng et al. 2002; Lacoste et al. 2002). DOT1L and H3K79me have been shown to be involved in active transcription and in particular has been shown to be important for MLL-AF4 leukaemia, where high levels of H3K79me are found at MLL-AF4 gene targets (Krivtsov et al ...
Laura Godfrey, Godfrey, Laura
openaire +3 more sources
Harnessing the hidden antitumor power of the MLL-AF4 oncogene to fight leukemia. [PDF]
Cancer Cell, 2014 It is unclear whether the antiproliferative/proapoptotic activity of oncogenes can be pharmacologically reactivated in cancer cells. In this issue of Cancer Cell, Liu and colleagues report that a proteasome inhibitor reactivates an MLL-AF4 controlled antitumor program to kill leukemia cells in an oncogene dose- and cell type-dependent manner.
Matkar S, Katona BW, Hua X.
europepmc +4 more sources
MLL-AF4 driven leukemogenesis: what are we missing? [PDF]
Cell Res, 2012 Infant pro-B acute lymphoblastic leukemia (ALL) harboring MLL-AF4 fusion proteins instigated by chromosomal translocation t(4;11), represents an aggressive, high-risk type of childhood leukemia, characterized by a very brief disease latency and undisputedly originates in utero.
Stam RW.
europepmc +4 more sources
Unraveling the Activation Mechanism of Taspase1 which Controls the Oncogenic AF4–MLL Fusion Protein
EBioMedicine, 2015 We have recently demonstrated that Taspase1-mediated cleavage of the AF4–MLL oncoprotein results in the formation of a stable multiprotein complex which forms the key event for the onset of acute proB leukemia in mice.
Gisbert Schneider +2 more
exaly +3 more sources
Modulation of cell cycle by graded expression of MLL-AF4 fusion oncoprotein [PDF]
Leukemia, 2004 Acute lymphoblastic leukemia (ALLs) expressing MLL-AF4, the fusion product of t(4;11)(q21;q23), show marked leucocytosis and extramedullary disease in multiple organs, respond poorly to chemotherapy and have poor prognosis. In vitro, leukemic cells with the t(4;11) show resistance to serum deprivation-induced or interferon gamma-regulated CD95-mediated
Martino Introna, Corrado Caslini
exaly +3 more sources
Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions [PDF]
Haematologica, 2019 The t(4;11)(q21;q23) translocation is associated with high-risk infant pro-B-cell acute lymphoblastic leukemia and arises prenatally during embryonic/fetal hematopoiesis.
Clara Bueno +17 more
doaj +2 more sources
PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia
, 2022 Summary Aberrant enhancer activation has been identified as a key mechanism driving oncogene expression in many cancers. Here we use TOPmentation (Transcription factor-OPtimized ChIPmentation) to probe enhancer usage in primary MLL-rearranged acute lymphoblastic leukemia.
Crump NT +13 more
europepmc +2 more sources
Clinical characteristics and prognostic analysis of different fusion gene abnormalities in childhood acute lymphoblastic leukaemia [PDF]
Frontiers in OncologyObjectiveThis study aimed to analyze the clinical features and prognostic significance of different fusion gene subtypes in pediatric patients with acute lymphoblastic leukaemia (ALL).MethodsClinical data from 132 childhood patients with ALL diagnosed ...
Rui Fan +9 more
doaj +2 more sources