Results 1 to 10 of about 2,749,571 (347)
Biomedical Journal, 2019 Protein tyrosine kinases (TKs) are a family of enzymes that catalyze the phosphorylation of proteins at tyrosine residues. TKs play key roles in controlling cell growth and many other functions by modulating the status of tyrosine phosphorylation of ...
Jau-Song Yu
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DRP1 Promotes BRAFV600E-Driven Tumor Progression and Metabolic Reprogramming in Colorectal Cancer
Frontiers in Oncology, 2021 BackgroundMitochondria are highly dynamic organelles which remain in a continuous state of fission/ fusion dynamics to meet the metabolic needs of a cell. However, this fission/fusion dynamism has been reported to be dysregulated in most cancers.
Rayees Ahmad Padder +4 more
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Haematologica, 2011 We report a patient with T-lymphoblastic leukemia/lymphoma and a t(7;8)(q22;p11). CUX1 was identified as the fusion partner of FGFR1 by fluorescence in situ hybridization and 5′ RACE-PCR.
Bartosz Wasag +4 more
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Frontiers in Oncology, 2020 Objective: Oncogenic echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) (EML4-ALK) fusion proteins found in non-small cell lung cancers (NSCLC) are constitutively phosphorylated and activated by dimerization via the ...
Noriko Hirai +5 more
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Potential roles of synaptotagmin family members in cancers: Recent advances and prospects
Frontiers in Medicine, 2022 With the continuous development of bioinformatics and public database, more and more genes that play a role in cancers have been discovered. Synaptotagmins (SYTs) are abundant, evolutionarily conserved integral membrane proteins composed of a short N ...
Huandan Suo, Nan Xiao, Kewei Wang
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Apoptosis resistance in chronic myelogenous leukemia [PDF]
Einstein (São Paulo), 2005 The chronic myeloid leukemia (CML) is the three-phasemyeloproliferative disorder, dependent on the expression of theoncoprotein Bcr-Abl, which is the product of the reciprocaltranslocation between chromosomes 9 and 22, resulting in thePhiladelphia ...
Fabíola Attié de Castro +4 more
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Haematologica, 2013 Acute lymphoblastic leukemia in infants represents an aggressive malignancy associated with a high incidence (approx. 80%) of translocations involving the Mixed Lineage Leukemia (MLL) gene.
Emma M.C. Driessen +7 more
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Changes in TFG gene expression in bovine leucocytes transformed by Theileria annulata
Frontiers in Veterinary Science, 2022 Theileria annulata schizont-infected host cells in culture in vitro show unlimited proliferation similar to tumor cells; thus far, T. annulata and T. parva are the only eukaryotes that have been found to transform mammalian cells (immortalized).
Hong-xi Zhao +4 more
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Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
Nature Communications, 2018 Altered mitochondrial dynamics can broadly impact tumor cell physiology. Using genetic and pharmacological profiling of cancer cell lines and human tumors, we here establish that perturbations to the mitochondrial dynamics network also result in specific
Gray R. Anderson +9 more
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Mechanisms of Oncogene Activation
, 2016 The main modifications that characterize cancer are represented by alterations in onco‐ genes, tumor-suppressor genes, and non-coding RNA genes. Most of these alterations are somatic and the process is a multistep one.
A. Botezatu +8 more
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