Frontiers in Oncology, 2023 Ewing sarcoma is a cancer of children and young adults characterized by the critical translocation-associated fusion oncoprotein EWSR1::FLI1. EWSR1::FLI1 targets characteristic genetic loci where it mediates aberrant chromatin and the establishment of de
Tamara Vital +31 more
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Maltose-binding protein enhances secretion of recombinant human granzyme B accompanied by in vivo processing of a precursor MBP fusion protein [PDF]
, 2010 Background: The apoptosis-inducing serine protease granzyme B (GrB) is an important factor contributing to lysis of target cells by cytotoxic lymphocytes.
Wels, Winfried +9 more
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Myeloproliferative neoplasms and the JAK/STAT signaling pathway: an overview
Revista Brasileira de Hematologia e Hemoterapia, 2015 Myeloproliferative neoplasms are caused by a clonal proliferation of a hematopoietic progenitor. First described in 1951 as 'Myeloproliferative Diseases' and reevaluated by the World Health Organization classification system in 2011, myeloproliferative ...
Renata Mendes de Freitas +1 more
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Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene.
Cytokine, 2017 Tyrosine kinase 2 (TYK2) is a member of the Janus kinase (JAK) family, which transduces cytokine and growth factor signalling. Analysis of TYK2 loss-of-function revealed its important role in immunity to infection, (auto-) immunity and (auto ...
Nicole R. Leitner +3 more
semanticscholar +1 more source
Orchestration of autophagosome fusion by STRIPAK complex components in muscle tissue
Autophagy Reports, 2023 Autophagy is a central process responsible for the disposal of normal as well as damaged cellular proteins and organelles. Proper regulation of multiple steps – including initiation and the fusion between autophagosomes and lysosomes – is essential for ...
Yungui Guo, Erika R. Geisbrecht
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Leukemia, 2010 ABL gene translocations create constitutively active tyrosine kinases that are causative in chronic myeloid leukemia, acute lymphocytic leukemia and other hematopoietic malignancies.
M. Thai +6 more
semanticscholar +1 more source
Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins [PDF]
Cancer Research, 2019 Abstract Chromosomal rearrangements involving receptor tyrosine kinases (RTK) are a clinically relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often contain the C-terminal kinase domain of the RTK joined in cis to various N-terminal, nonkinase fusion partners.
Dana S. Neel +15 more
openaire +5 more sources
Improvement of downstream processing of recombinant proteins by means of genetic engineering [PDF]
, 1993 Flaschel E, Friehs K. Improvement of downstream processing of recombinant proteins by means of genetic engineering. Biotechnology Advances. 1993;11(1):31-77.The rapid advancement of genetic engineering has allowed to produce an impressive number of ...
Flaschel, Erwin, Friehs, Karl
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Versatile toolbox for high throughput biochemical and functional studies with fluorescent fusion proteins [PDF]
, 2012 Fluorescent fusion proteins are widely used to study protein localization and interaction dynamics in living cells. However, to fully characterize proteins and to understand their function it is crucial to determine biochemical characteristics such as ...
Sandra B. Hake (165089) +15 more
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Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner [PDF]
Leukemia, 2015 Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent ...
S, He +14 more
openaire +2 more sources