Results 41 to 50 of about 103,602 (308)

Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway [PDF]

Molecular Cancer, 2018
The insulin-like growth factor-1 receptor (IGF1R) has been identified as a potent anti-apoptotic, pro-survival tyrosine kinase-containing receptor. Overexpression of the IGF1R gene constitutes a typical feature of most human cancers. Consistent with these biological roles, cells expressing high levels of IGF1R are expected not to die, a quintessential ...
Haim Werner, Shilhav Meisel-Sharon, Ilan Bruchim   +2 more
openaire   +3 more sources

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia [PDF]

Nature Chemical Biology, 2012
Translocations involving the mixed lineage leukemia (MLL) gene result in human acute leukemias with very poor prognosis. The leukemogenic activity of MLL fusion proteins is critically dependent on their direct interaction with menin, a product of the multiple endocrine neoplasia (MEN1) gene.
Jolanta, Grembecka, Shihan, He, Aibin, Shi, Trupta, Purohit, Andrew G, Muntean, Roderick J, Sorenson, Hollis D, Showalter, Marcelo J, Murai, Amalia M, Belcher, Thomas, Hartley, Jay L, Hess, Tomasz, Cierpicki   +11 more
openaire   +2 more sources

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez (123610), Beez, Sabine, Philipp Demmer, Elena Puccetti (66633), Philipp Demmer (123611), Puccetti, Elena, Elena Puccetti, Sabine Beez, Demmer, Philipp   +8 more
core   +1 more source

Intrinsic Structural Disorder Confers Cellular Viability on Oncogenic Fusion Proteins

PLoS Computational Biology, 2009
Chromosomal translocations, which often generate chimeric proteins by fusing segments of two distinct genes, represent the single major genetic aberration leading to cancer. We suggest that the unifying theme of these events is a high level of intrinsic structural disorder, enabling fusion proteins to evade cellular surveillance mechanisms that ...
Hedi Hegyi, László Buday, Peter Tompa
openaire   +4 more sources

Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Alternative splicing of RNA allows a limited number of coding regions in the human genome to produce proteins with diverse functionality. Alternative splicing has also been implicated as an oncogenic process. Identifying aspects of cancer cells that differentiate them from noncancer cells remains an ongoing challenge, and
Saravana P. Selvanathan, Garrett T. Graham, Hayriye V. Erkizan, Uta Dirksen, Thanemozhi G. Natarajan, Aleksandra Dakic, Songtao Yu, Xuefeng Liu, Michelle T. Paulsen, Mats E. Ljungman, Cathy H. Wu, Elizabeth R. Lawlor, Aykut Üren, Jeffrey A. Toretsky   +13 more
openaire   +2 more sources

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia [PDF]

, 2012
MECOM oncogene expression correlates with chronic myeloid leukaemia (CML) progression. Here we show that the knockdown of MECOM (E) and MECOM (ME) isoforms reduces cell division at low cell density, inhibits colony-forming cells by 34% and moderately ...
Jørgensen, Heather G., Holyoake, T.L., Holyoake, T., Abed El Baky, Mohamed, Bartholomew, C., Melo, Junia V., Roy, P., Melo, J.V., Abed El Baky, M., Roy, S., Jørgensen, H., Jorgensen, H.G., Strathdee, G., Strathdee, Gordon, Melo, J., Roy, Swagata, Holyoake, Tessa L., Roy, Poornima, Bartholomew, Christopher   +18 more
core   +1 more source

The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability [PDF]

Oncogene, 2012
Acute promyelocytic leukemia (APL) is predominantly characterized by chromosomal translocations between the retinoic acid receptor, alpha (RARA) gene and the promyelocytic leukemia (PML) or promyelocytic leukemia zinc finger (PLZF) gene. In APL cells with PML/RARA fusions, arsenic trioxide and all-trans retinoic acid treatments specifically target the ...
W-C, Yang, H-M, Shih
openaire   +2 more sources

Coordinated oncogenic transformation and inhibition of host immune responses by the PAX3-FKHR fusion oncoprotein

, 2005
Tumors have evolved elaborate mechanisms for evading immune detection, such as production of immunoinhibitory cytokines and down-regulation of major histocompatibility complex (MHC) expression.
Hubank, M, Antigoni Papanastasiou, Nabarro, S, Sebire, N, Himoudi, N, Papanastasiou, A, Blundell, MP, Gibson, S, Gilmour, K, Anderson, J, Adrian Thrasher, Neil Sebire, John Anderson, Mike Hubank, Nourredine Himoudi, Kimberly Gilmour, Sian Gibson, Canderan, G, Stephen Nabarro, Glenda Canderan, Thrasher, A, Michael P. Blundell   +21 more
core   +1 more source

FGFR–TACC Fusion Proteins Are Oncogenic in Glioblastoma [PDF]

Cancer Discovery, 2012
Abstract Fusion proteins combining FGFR and TACC are transforming in a subset of glioblastomas.
openaire   +1 more source

Reciprocal t(9;22) ABL/BCR fusion proteins: leukemogenic potential and effects on B cell commitment

, 2009
Background: t(9;22) is a balanced translocation, and the chromosome 22 breakpoints (Philadelphia chromosome – Ph+) determine formation of different fusion genes that are associated with either Ph+ acute lymphatic leukemia (Ph+ ALL) or chronic myeloid ...
Xiaomin Zheng, Malcolm A S Moore, Martin Ruthardt, Ruthardt, Martin, Oancea, Claudia, Claudia Oancea, Malcolm A. S. Moore, Reinhard Henschler, Henschler, Reinhard, Moore, Malcolm A. S., Zheng, Xiaomin   +10 more
core   +1 more source